SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		4 / 7 ILE A  48
ASP A  79
GLY A  54
PHE A  50
 None
 0.89A 1rtsB-4zf4A:
undetectable		 1rtsB-4zf4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 12 LEU A 237
LEU A 235
ILE A 207
ALA A 230
PHE A  21
 4NT  A  15 ( 4.9A)
4NT  A  15 ( 4.8A)
None
None
None
 1.11A 2qb4A-4zf4A:
undetectable		 2qb4A-4zf4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		4 / 6 ILE A 138
PHE A  33
ALA A  37
ASN A 135
 None
 1.13A 3pgyA-4zf4A:
undetectable
3pgyB-4zf4A:
undetectable		 3pgyA-4zf4A:
20.15
3pgyB-4zf4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.19A 3t3rB-4zf4A:
undetectable		 3t3rB-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.23A 3t3rC-4zf4A:
undetectable		 3t3rC-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.18A 3t3rD-4zf4A:
undetectable		 3t3rD-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		4 / 6 THR A  78
ASN A 216
GLY A 217
ASP A 214
 None
 1.23A 3w9tE-4zf4A:
undetectable		 3w9tE-4zf4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		4 / 6 VAL A   5
LEU A   3
LEU A  75
PHE A 115
 None
None
None
4NT  A  15 ( 4.2A)
 0.90A 4o1zA-4zf4A:
undetectable		 4o1zA-4zf4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.47A 4qi9A-4zf4A:
undetectable		 4qi9A-4zf4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 11 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.40A 4qleB-4zf4A:
undetectable		 4qleB-4zf4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.37A 4qlgA-4zf4A:
undetectable		 4qlgA-4zf4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.35A 4qlgB-4zf4A:
undetectable		 4qlgB-4zf4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.44A 4x5hA-4zf4A:
undetectable		 4x5hA-4zf4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.43A 4x5iA-4zf4A:
undetectable		 4x5iA-4zf4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		3 / 3 LYS A 194
ARG A  30
HIS A  31
 None
 1.16A 4zbrA-4zf4A:
undetectable		 4zbrA-4zf4A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.41A 5eajA-4zf4A:
undetectable		 5eajA-4zf4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		4 / 7 ILE A  48
ASP A  79
GLY A  54
PHE A  50
 None
 0.92A 5h3aA-4zf4A:
undetectable		 5h3aA-4zf4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		6 / 12 ALA A  60
LEU A  14
ILE A 207
LEU A 235
TYR A  42
THR A  58
 None
4NT  A  15 ( 4.2A)
None
4NT  A  15 ( 4.8A)
None
None
 1.41A 5ujxA-4zf4A:
undetectable		 5ujxA-4zf4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		3 / 3 LYS A  90
ASN A  85
SER A 125
 None
 1.18A 5yw0A-4zf4A:
undetectable		 5yw0A-4zf4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  36
LEU A 151
SER A  22
ILE A 102
PRO A 146
 None
 1.45A 6dlzB-4zf4A:
undetectable
6dlzC-4zf4A:
undetectable		 6dlzB-4zf4A:
16.27
6dlzC-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 11 ILE A 102
PRO A 146
SER A  36
LEU A 151
SER A  22
 None
 1.45A 6dlzA-4zf4A:
undetectable
6dlzD-4zf4A:
undetectable		 6dlzA-4zf4A:
16.27
6dlzD-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  36
LEU A 151
SER A  22
ILE A 102
PRO A 146
 None
 1.45A 6dm1B-4zf4A:
undetectable
6dm1C-4zf4A:
undetectable		 6dm1B-4zf4A:
16.27
6dm1C-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 11 ILE A 102
PRO A 146
SER A  36
LEU A 151
SER A  22
 None
 1.45A 6dm1A-4zf4A:
undetectable
6dm1D-4zf4A:
undetectable		 6dm1A-4zf4A:
16.27
6dm1D-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  36
LEU A 151
SER A  22
ILE A 102
PRO A 146
 None
 1.44A 6dm2B-4zf4A:
undetectable
6dm2C-4zf4A:
undetectable		 6dm2B-4zf4A:
16.27
6dm2C-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 ILE A 102
PRO A 146
SER A  36
LEU A 151
SER A  22
 None
 1.45A 6dm2A-4zf4A:
undetectable
6dm2D-4zf4A:
undetectable		 6dm2A-4zf4A:
16.27
6dm2D-4zf4A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4zf4 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 12 VAL A  11
LEU A  10
PHE A 220
PHE A  50
PHE A  80
 4NT  A  15 ( 4.5A)
None
None
None
None
 1.16A 6drzA-4zf4A:
undetectable		 6drzA-4zf4A:
19.18