SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A  53
LEU A  51
ILE A  95
GLY A  58
LEU A  90
 None
 1.26A 1g50B-4zfhA:
undetectable		 1g50B-4zfhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 11 LEU A  53
LEU A  51
ILE A  95
GLY A  58
LEU A  90
 None
 1.26A 1g50C-4zfhA:
undetectable		 1g50C-4zfhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		4 / 4 ASP A  13
LEU A  18
LEU A  19
LEU A  14
 None
 1.34A 1u18A-4zfhA:
undetectable		 1u18A-4zfhA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A  53
LEU A  51
ILE A  95
GLY A  58
LEU A  90
 None
 1.27A 2j7xA-4zfhA:
undetectable		 2j7xA-4zfhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A 133
SER A 153
ILE A 152
ALA A 121
THR A 148
 None
 1.21A 2japA-4zfhA:
undetectable		 2japA-4zfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A 133
SER A 153
ILE A 152
ALA A 121
THR A 148
 None
 1.24A 2japB-4zfhA:
undetectable		 2japB-4zfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A 133
SER A 153
ILE A 152
ALA A 121
THR A 148
 None
 1.23A 2japC-4zfhA:
undetectable		 2japC-4zfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A 133
SER A 153
ILE A 152
ALA A 121
THR A 148
 None
 1.24A 2japD-4zfhA:
undetectable		 2japD-4zfhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.16A 3erdA-4zfhA:
undetectable		 3erdA-4zfhA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.14A 3hm1A-4zfhA:
undetectable		 3hm1A-4zfhA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 11 ILE A  62
LEU A  51
HIS A  69
LEU A  67
ALA A  71
 None
 1.08A 4p65E-4zfhA:
undetectable
4p65F-4zfhA:
undetectable
4p65J-4zfhA:
undetectable
4p65L-4zfhA:
undetectable		 4p65E-4zfhA:
8.65
4p65F-4zfhA:
12.41
4p65J-4zfhA:
12.41
4p65L-4zfhA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 11 ILE A 128
LEU A 117
HIS A 135
LEU A 133
ALA A 137
 None
MG  A 204 ( 3.7A)
None
None
MG  A 203 (-3.5A)
 1.10A 4p65E-4zfhA:
undetectable
4p65F-4zfhA:
undetectable
4p65J-4zfhA:
undetectable
4p65L-4zfhA:
undetectable		 4p65E-4zfhA:
8.65
4p65F-4zfhA:
12.41
4p65J-4zfhA:
12.41
4p65L-4zfhA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 1.03A 4p65B-4zfhA:
undetectable
4p65D-4zfhA:
undetectable
4p65I-4zfhA:
undetectable
4p65J-4zfhA:
undetectable		 4p65B-4zfhA:
12.41
4p65D-4zfhA:
12.41
4p65I-4zfhA:
8.65
4p65J-4zfhA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		5 / 11 LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
 None
 1.19A 4zn7B-4zfhA:
undetectable		 4zn7B-4zfhA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens) 		4 / 8 HIS A  69
LEU A  14
GLY A  15
LEU A  18
 None
 0.72A 6mdqA-4zfhA:
undetectable		 6mdqA-4zfhA:
22.31