SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A  45
ALA A 102
VAL A  87
 None
 0.89A 1c4dA-4zflA:
undetectable
1c4dB-4zflA:
undetectable		 1c4dA-4zflA:
7.34
1c4dB-4zflA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ARG A  12
ASP A 201
ASP A 203
TRP A 206
 None
 1.41A 1ceaB-4zflA:
undetectable		 1ceaB-4zflA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 140
SER A 143
LEU A 149
ALA A 148
ILE A 153
 None
 1.02A 1g5yC-4zflA:
undetectable		 1g5yC-4zflA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 110
ALA A  85
LEU A  17
PRO A  11
ALA A 170
 None
 1.00A 3dfrA-4zflA:
undetectable		 3dfrA-4zflA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A  20
PRO A  22
GLN A  23
ARG A 189
 None
 1.28A 3s3oA-4zflA:
undetectable		 3s3oA-4zflA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 217
LEU A 111
TRP A 109
ALA A 177
LEU A 195
 None
 1.13A 4coxA-4zflA:
undetectable		 4coxA-4zflA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_1
(DNA ADENINE
METHYLASE)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		4 / 4 TRP A  59
SER A 101
ASP A  68
ASP A  62
 None
 1.33A 4rtmA-4zflA:
0.0		 4rtmA-4zflA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A  60
ARG A  88
ALA A  86
PHE A 104
 None
4NK  A 301 (-3.5A)
None
None
 1.24A 5odqA-4zflA:
undetectable		 5odqA-4zflA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4zfl AMIDOHYDROLASE EGTC
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 201
GLN A  28
ASP A 211
ASP A 208
ILE A 209
 None
 1.07A 6fzbB-4zflA:
undetectable		 6fzbB-4zflA:
19.90