SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.85A 1av2C-4zfmA:
undetectable
1av2D-4zfmA:
undetectable		 1av2C-4zfmA:
2.93
1av2D-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A  95
VAL A  88
TRP A  85
 None
 0.76A 1c4dC-4zfmA:
undetectable
1c4dD-4zfmA:
undetectable		 1c4dC-4zfmA:
2.93
1c4dD-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
SER A 224
ASN A 169
THR A 121
 None
 1.12A 1h7xA-4zfmA:
10.7		 1h7xA-4zfmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
SER A 224
ASN A 169
THR A 121
 None
 1.11A 1h7xB-4zfmA:
11.3		 1h7xB-4zfmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
SER A 224
ASN A 169
THR A 121
 None
 1.13A 1h7xC-4zfmA:
7.0		 1h7xC-4zfmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
SER A 224
ASN A 169
THR A 121
 None
 1.12A 1h7xD-4zfmA:
11.2		 1h7xD-4zfmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A 466
 None
 0.76A 1kqeA-4zfmA:
undetectable
1kqeE-4zfmA:
undetectable		 1kqeA-4zfmA:
2.19
1kqeE-4zfmA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A 466
 None
 0.79A 1kqeB-4zfmA:
undetectable
1kqeD-4zfmA:
undetectable		 1kqeB-4zfmA:
2.19
1kqeD-4zfmA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 466
ALA A 476
VAL A 470
 None
 0.79A 1kqeB-4zfmA:
undetectable
1kqeD-4zfmA:
undetectable		 1kqeB-4zfmA:
2.19
1kqeD-4zfmA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 466
ALA A 476
VAL A 470
 None
 0.80A 1kqeA-4zfmA:
undetectable
1kqeE-4zfmA:
undetectable		 1kqeA-4zfmA:
2.19
1kqeE-4zfmA:
2.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A 466
 None
 0.84A 1micA-4zfmA:
undetectable
1micB-4zfmA:
undetectable		 1micA-4zfmA:
2.93
1micB-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 309
ALA A 242
ASN A 239
 None
 0.81A 1n4fA-4zfmA:
undetectable		 1n4fA-4zfmA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.87A 1nt5A-4zfmA:
undetectable		 1nt5A-4zfmA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.87A 1nt5B-4zfmA:
undetectable		 1nt5B-4zfmA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.86A 1nt6A-4zfmA:
undetectable		 1nt6A-4zfmA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.86A 1nt6B-4zfmA:
undetectable		 1nt6B-4zfmA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 430
VAL A  58
ARG A 440
THR A 428
 None
 1.49A 1nw3A-4zfmA:
undetectable		 1nw3A-4zfmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 303
THR A 304
PRO A 229
 None
 0.85A 1qfiA-4zfmA:
undetectable		 1qfiA-4zfmA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 401
HIS A 405
LEU A 359
TYR A 301
 None
 1.18A 1tuvA-4zfmA:
undetectable		 1tuvA-4zfmA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.83A 1w5uC-4zfmA:
undetectable
1w5uD-4zfmA:
undetectable		 1w5uC-4zfmA:
2.93
1w5uD-4zfmA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLU A 110
TYR A  64
ASP A 105
PHE A 158
 None
 1.47A 2a3bB-4zfmA:
12.2		 2a3bB-4zfmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 TYR A  64
ARG A 157
VAL A 120
TYR A 104
GLU A  98
 None
 1.35A 2fl5A-4zfmA:
undetectable
2fl5B-4zfmA:
undetectable
2fl5F-4zfmA:
undetectable		 2fl5A-4zfmA:
18.28
2fl5B-4zfmA:
20.34
2fl5F-4zfmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_H_RBFH201_1
(IMMUNOGLOBULIN IGG1
HEAVY CHAIN
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A  98
ARG A 157
VAL A 120
TYR A 104
TYR A  64
 None
 1.32A 2fl5D-4zfmA:
0.0
2fl5H-4zfmA:
0.0
2fl5L-4zfmA:
0.0		 2fl5D-4zfmA:
20.34
2fl5H-4zfmA:
20.34
2fl5L-4zfmA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
ILE A 173
GLN A 170
THR A 121
 None
None
BG6  A 501 (-3.0A)
None
 1.21A 2hkkA-4zfmA:
undetectable		 2hkkA-4zfmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 478
LEU A 359
PRO A  10
VAL A 419
GLY A 421
 None
 1.21A 2po7A-4zfmA:
0.6		 2po7A-4zfmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 478
LEU A 359
PRO A  10
VAL A 419
GLY A 421
 None
 1.22A 2po7B-4zfmA:
0.0		 2po7B-4zfmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 288
ASP A 284
ILE A 200
ARG A 141
 None
 1.07A 2qqdA-4zfmA:
undetectable
2qqdE-4zfmA:
undetectable		 2qqdA-4zfmA:
7.08
2qqdE-4zfmA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A  79
ASN A 169
HIS A 124
ALA A  20
 None
None
BG6  A 501 (-4.2A)
BG6  A 501 ( 4.9A)
 1.29A 3frqB-4zfmA:
undetectable		 3frqB-4zfmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 ARG A 213
PRO A 373
GLY A 222
PRO A 223
MET A 296
 None
 1.40A 3hcoA-4zfmA:
undetectable		 3hcoA-4zfmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 ARG A 213
PRO A 373
GLY A 222
PRO A 223
MET A 296
 None
 1.40A 3hcoB-4zfmA:
1.2		 3hcoB-4zfmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 168
ILE A 221
GLY A 222
PRO A 223
TYR A 258
 None
 1.11A 3hgiA-4zfmA:
undetectable		 3hgiA-4zfmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 476
VAL A 470
TRP A  15
 None
 0.76A 3l8lC-4zfmA:
undetectable
3l8lD-4zfmA:
undetectable		 3l8lC-4zfmA:
2.93
3l8lD-4zfmA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A 155
VAL A 216
GLY A 219
GLY A 159
 None
 0.74A 3n9jB-4zfmA:
undetectable		 3n9jB-4zfmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 ALA A  78
GLY A 421
ILE A 376
VAL A 166
ILE A 119
 None
 1.11A 3ndwB-4zfmA:
undetectable		 3ndwB-4zfmA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A  61
ASP A  59
ASP A  55
 None
IMD  A 507 (-3.4A)
None
 0.87A 3ou7B-4zfmA:
undetectable		 3ou7B-4zfmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 TYR A 195
ALA A 197
ARG A 193
LEU A 276
 None
 1.10A 3rd0A-4zfmA:
undetectable		 3rd0A-4zfmA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 209
PRO A 293
SER A 224
GLY A 222
 None
 1.00A 3tkdB-4zfmA:
undetectable		 3tkdB-4zfmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 209
PRO A 293
SER A 224
GLY A 222
 None
 1.02A 3tkdA-4zfmA:
undetectable		 3tkdA-4zfmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A  51
THR A  48
ASN A  53
 None
 0.69A 3v4tD-4zfmA:
undetectable		 3v4tD-4zfmA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 149
TRP A  85
GLY A  92
 None
 0.62A 4e7cA-4zfmA:
undetectable		 4e7cA-4zfmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 4 SER A  82
GLY A  54
GLU A 453
 None
None
IMD  A 507 (-2.5A)
 0.62A 4juoA-4zfmA:
undetectable
4juoC-4zfmA:
undetectable		 4juoA-4zfmA:
20.85
4juoC-4zfmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 258
ALA A 201
ASN A 198
ILE A 175
 None
 1.20A 4y03B-4zfmA:
undetectable		 4y03B-4zfmA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A  64
TYR A  22
ASP A  59
ALA A  57
TYR A 437
 None
None
IMD  A 507 (-3.4A)
None
None
 1.37A 4ymgB-4zfmA:
undetectable		 4ymgB-4zfmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 181
GLY A 178
GLU A 139
GLY A 187
GLY A 182
 None
 1.00A 4yvgA-4zfmA:
undetectable		 4yvgA-4zfmA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A  47
VAL A  37
TRP A  38
 None
 1.23A 5fvoA-4zfmA:
0.1		 5fvoA-4zfmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 295
PRO A 293
THR A 167
ILE A 221
 None
 1.32A 5ih0A-4zfmA:
undetectable		 5ih0A-4zfmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A  22
THR A  52
TRP A 433
LEU A 434
 None
None
BG6  A 501 (-4.1A)
None
 1.47A 5kxiA-4zfmA:
undetectable
5kxiB-4zfmA:
undetectable		 5kxiA-4zfmA:
22.49
5kxiB-4zfmA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 175
TYR A 179
GLY A 178
HIS A 184
ALA A 201
 None
 1.21A 5n0wA-4zfmA:
undetectable		 5n0wA-4zfmA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 175
TYR A 179
GLY A 178
HIS A 184
ALA A 201
 None
 1.21A 5n0xB-4zfmA:
undetectable		 5n0xB-4zfmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 199
ASN A 202
ALA A 206
 None
 0.26A 5n4tB-4zfmA:
1.3		 5n4tB-4zfmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5ttfB-4zfmA:
undetectable		 5ttfB-4zfmA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.25A 5tuyA-4zfmA:
undetectable		 5tuyA-4zfmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.26A 5tuyB-4zfmA:
undetectable		 5tuyB-4zfmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A  15
THR A 473
ARG A 403
GLN A 407
 None
 1.26A 5tzoA-4zfmA:
undetectable		 5tzoA-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A  15
THR A 473
ARG A 403
GLN A 407
 None
 1.25A 5tzoB-4zfmA:
undetectable		 5tzoB-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A  15
THR A 473
ARG A 403
GLN A 407
 None
 1.22A 5tzoC-4zfmA:
undetectable		 5tzoC-4zfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.35A 5v9iA-4zfmA:
undetectable		 5v9iA-4zfmA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vscA-4zfmA:
undetectable		 5vscA-4zfmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vscB-4zfmA:
undetectable		 5vscB-4zfmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
TRP A  38
 None
BG6  A 501 (-3.4A)
None
None
None
 1.27A 5vsdA-4zfmA:
undetectable		 5vsdA-4zfmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.33A 5vseA-4zfmA:
undetectable		 5vseA-4zfmA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vseB-4zfmA:
undetectable		 5vseB-4zfmA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
TRP A  38
 None
BG6  A 501 (-3.4A)
None
None
None
 1.26A 5vsfA-4zfmA:
undetectable		 5vsfA-4zfmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  32
PHE A  89
PHE A 103
TYR A 150
TYR A  61
 None
 1.43A 5yf0A-4zfmA:
undetectable		 5yf0A-4zfmA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLN A 210
VAL A 208
ALA A 151
THR A 153
 None
 1.05A 6cduB-4zfmA:
undetectable
6cduC-4zfmA:
undetectable		 6cduB-4zfmA:
22.38
6cduC-4zfmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 ASP A 284
ALA A 291
ARG A 141
SER A 140
VAL A 208
 None
 1.18A 6clxA-4zfmA:
undetectable		 6clxA-4zfmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 TRP A  85
LEU A 203
TYR A 135
GLN A 129
 None
 1.29A 6djzC-4zfmA:
undetectable		 6djzC-4zfmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A 126
GLN A  23
LEU A 430
SER A  19
 None
BG6  A 501 (-3.1A)
None
None
 1.22A 6ekuA-4zfmA:
undetectable		 6ekuA-4zfmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A  64
HIS A  60
PHE A 103
 None
 0.94A 6esmA-4zfmA:
undetectable		 6esmA-4zfmA:
9.69