SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 8 GLU A  62
ARG A  65
ARG A  66
GLU A 163
 None
None
EDO  A 307 (-4.9A)
EDO  A 307 (-3.5A)
 0.67A 1cmaA-4zfzA:
undetectable
1cmaB-4zfzA:
undetectable		 1cmaA-4zfzA:
16.55
1cmaB-4zfzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
None
None
EDO  A 307 ( 3.9A)
None
 1.39A 2wuzA-4zfzA:
undetectable		 2wuzA-4zfzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
None
None
EDO  A 307 ( 3.9A)
None
 1.36A 2wuzB-4zfzA:
undetectable		 2wuzB-4zfzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.96A 2zm8A-4zfzA:
undetectable		 2zm8A-4zfzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 5 VAL A  24
VAL A  25
THR A  64
THR A  10
 None
 1.22A 3bjwA-4zfzA:
undetectable		 3bjwA-4zfzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 5 VAL A  24
VAL A  25
THR A  64
THR A  10
 None
 1.18A 3bjwC-4zfzA:
undetectable		 3bjwC-4zfzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 5 VAL A  24
VAL A  25
THR A  64
THR A  10
 None
 1.24A 3bjwD-4zfzA:
undetectable		 3bjwD-4zfzA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 7 GLU A 253
GLU A 254
ARG A 273
ARG A 256
 None
ZN  A 301 (-2.1A)
None
None
 0.99A 4fgzA-4zfzA:
undetectable		 4fgzA-4zfzA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 7 TYR A 159
TYR A 171
GLN A  63
ARG A  66
 EDO  A 307 ( 4.9A)
EDO  A 307 (-4.5A)
EDO  A 307 ( 3.5A)
EDO  A 307 (-4.9A)
 1.37A 4qzuB-4zfzA:
1.0		 4qzuB-4zfzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
 1.42A 5m5kA-4zfzA:
undetectable		 5m5kA-4zfzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 4 GLN A 218
THR A 216
THR A 187
LEU A 266
 None
 1.43A 5m5kC-4zfzA:
undetectable		 5m5kC-4zfzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 7 GLN A 180
GLN A  63
TYR A  59
ASP A 102
 ZN  A 304 ( 2.5A)
EDO  A 307 ( 3.5A)
None
None
 1.14A 5vlmE-4zfzA:
undetectable		 5vlmE-4zfzA:
20.14