SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 12 GLN D  39
GLY D 105
GLY D  15
THR D   6
ALA D  34
 None
 1.12A 1jg4A-4zg5D:
undetectable		 1jg4A-4zg5D:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		4 / 8 VAL D 175
PHE D 167
ALA D 145
GLN D 125
 None
 0.99A 2ij7C-4zg5D:
undetectable		 2ij7C-4zg5D:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		3 / 3 ASP D 217
THR D 232
PRO D 233
 None
 0.60A 2q64B-4zg5D:
undetectable		 2q64B-4zg5D:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 12 SER D 124
ASN D 166
THR D 106
VAL D 107
LEU D 162
 None
 1.21A 2xrlA-4zg5D:
undetectable		 2xrlA-4zg5D:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 THR D 181
ILE D 224
LEU D 165
ILE D 229
THR D 140
 None
 1.16A 3a50B-4zg5D:
undetectable		 3a50B-4zg5D:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 THR D 181
ILE D 224
LEU D 165
ILE D 229
THR D 140
 None
 1.20A 3a50C-4zg5D:
undetectable		 3a50C-4zg5D:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 LEU D  80
GLY D  75
ILE D  73
PRO D  68
THR D   6
 None
 1.25A 3bjwB-4zg5D:
undetectable		 3bjwB-4zg5D:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 LEU D  80
GLY D  75
ILE D  73
PRO D  68
THR D   6
 None
 1.32A 3bjwE-4zg5D:
undetectable		 3bjwE-4zg5D:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 12 LEU D  80
GLY D  75
ILE D  73
PRO D  68
THR D   6
 None
 1.22A 3bjwF-4zg5D:
undetectable		 3bjwF-4zg5D:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 LEU D  80
GLY D  75
ILE D  73
PRO D  68
THR D   6
 None
 1.25A 3bjwH-4zg5D:
undetectable		 3bjwH-4zg5D:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		3 / 3 SER D 104
GLY D 105
THR D 106
 None
 0.11A 3k9wA-4zg5D:
2.9		 3k9wA-4zg5D:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		3 / 3 ASP D 217
THR D 232
PRO D 233
 None
 0.62A 3tkgD-4zg5D:
undetectable		 3tkgD-4zg5D:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 12 PHE D 167
PRO D 168
ALA D 223
ALA D  98
GLY D 184
 None
 0.92A 4oaeA-4zg5D:
undetectable		 4oaeA-4zg5D:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		4 / 8 LEU D  88
ALA D  23
ILE D  22
LEU D  16
 None
 0.73A 4wboB-4zg5D:
undetectable		 4wboB-4zg5D:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 10 GLY D  41
ASN D  96
ASP D 100
TYR D 103
SER D 104
 None
 0.75A 4xj7C-4zg5D:
31.0
4xj7D-4zg5D:
31.1		 4xj7C-4zg5D:
38.18
4xj7D-4zg5D:
38.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 11 GLN D  39
ALA D  17
GLY D  15
ALA D  13
ASP D  38
 None
None
None
None
MG  D 301 ( 4.7A)
 1.35A 5bxnV-4zg5D:
undetectable
5bxnW-4zg5D:
undetectable		 5bxnV-4zg5D:
26.26
5bxnW-4zg5D:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		4 / 7 GLY D  15
GLY D  90
SER D  89
ASP D   9
 None
None
None
MG  D 301 (-2.6A)
 0.65A 5ergB-4zg5D:
undetectable		 5ergB-4zg5D:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		4 / 8 LEU D  16
ILE D  11
PRO D  35
ALA D  63
 None
 1.05A 5m0oC-4zg5D:
undetectable		 5m0oC-4zg5D:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 10 PRO D  84
ILE D 121
LEU D   4
VAL D 118
LEU D 116
 None
 0.94A 5tixB-4zg5D:
undetectable		 5tixB-4zg5D:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		5 / 10 PRO D  84
LEU D   4
VAL D 118
LEU D 116
GLU D 112
 None
 0.96A 5tixB-4zg5D:
undetectable		 5tixB-4zg5D:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zg5 5'-NUCLEOTIDASE SURE
(Brucella
abortus) 		3 / 3 GLN D 125
ILE D  11
HIS D  12
 None
 0.70A 5z12B-4zg5D:
undetectable		 5z12B-4zg5D:
16.73