SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 GLU A 219
LEU A  70
GLY A 153
GLY A 198
ALA A 193
 CA  A 501 (-2.2A)
None
None
None
None
 1.19A 1httD-4zg8A:
undetectable		 1httD-4zg8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 SER A 305
SER A 412
ASN A 404
ASP A 398
 None
 1.05A 1hwiB-4zg8A:
undetectable		 1hwiB-4zg8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 SER A 305
SER A 412
ASN A 404
ASP A 398
 None
 1.06A 1hwkA-4zg8A:
undetectable		 1hwkA-4zg8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 SER A 305
SER A 412
ASN A 404
ASP A 398
 None
 1.06A 1hwkC-4zg8A:
undetectable		 1hwkC-4zg8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 SER A 305
SER A 412
ASN A 404
ASP A 398
 None
 1.06A 1hwkD-4zg8A:
undetectable		 1hwkD-4zg8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
 None
None
None
None
BTB  A 505 (-4.4A)
 1.04A 1nbhA-4zg8A:
undetectable		 1nbhA-4zg8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
 None
None
None
None
BTB  A 505 (-4.4A)
 1.04A 1nbhD-4zg8A:
undetectable		 1nbhD-4zg8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
 None
None
None
None
BTB  A 505 (-4.4A)
 1.24A 1nbiC-4zg8A:
undetectable		 1nbiC-4zg8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
 None
None
None
None
BTB  A 505 (-4.4A)
 1.22A 1nbiD-4zg8A:
undetectable		 1nbiD-4zg8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 6 GLY A 304
ILE A 411
TRP A 299
SER A 412
 None
 0.98A 1rs7B-4zg8A:
undetectable		 1rs7B-4zg8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 VAL A  66
ARG A 307
GLU A 414
ASP A  64
 None
None
BTB  A 505 (-3.2A)
None
 1.04A 1s3zA-4zg8A:
undetectable
1s3zB-4zg8A:
undetectable		 1s3zA-4zg8A:
16.90
1s3zB-4zg8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		3 / 3 MET A 237
ASN A 272
GLN A 246
 None
 0.99A 1xoqB-4zg8A:
undetectable		 1xoqB-4zg8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		3 / 3 GLN A  26
HIS A 362
ARG A 363
 None
 0.79A 1zlqA-4zg8A:
undetectable		 1zlqA-4zg8A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 LEU A 297
LEU A 306
TYR A 339
ALA A 313
ALA A 316
 None
 1.09A 2bm9A-4zg8A:
undetectable		 2bm9A-4zg8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 LEU A 297
LEU A 306
TYR A 339
ALA A 313
ALA A 316
 None
 1.14A 2bm9D-4zg8A:
undetectable		 2bm9D-4zg8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ALA A 144
LYS A 110
GLY A  69
LEU A  70
LEU A  55
 None
 1.28A 2nv4A-4zg8A:
undetectable		 2nv4A-4zg8A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 GLY A  58
MET A  72
LEU A 164
CYH A 111
VAL A 122
 None
 1.29A 2w8yA-4zg8A:
undetectable		 2w8yA-4zg8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 7 LEU A 105
ILE A  80
ALA A 259
ILE A 315
 None
 0.83A 2xkwA-4zg8A:
undetectable		 2xkwA-4zg8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 VAL A 349
GLY A 391
ALA A 421
GLY A 422
LEU A 427
 None
 0.88A 3ku1A-4zg8A:
undetectable		 3ku1A-4zg8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 VAL A 349
GLY A 391
ALA A 421
GLY A 422
LEU A 427
 None
 0.87A 3ku1C-4zg8A:
undetectable		 3ku1C-4zg8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ASP A  47
ALA A 144
ASN A  50
ASP A  64
ARG A 142
 None
 1.48A 3wenA-4zg8A:
undetectable		 3wenA-4zg8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ASP A  47
ALA A 144
ASN A  50
ASP A  64
ARG A 142
 None
 1.50A 3weoA-4zg8A:
undetectable		 3weoA-4zg8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 ASN A 413
ASP A 406
ASP A 405
VAL A 350
 None
 0.83A 4f8hA-4zg8A:
undetectable
4f8hB-4zg8A:
undetectable		 4f8hA-4zg8A:
22.45
4f8hB-4zg8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 8 ASN A 413
ASP A 406
ASP A 405
VAL A 350
 None
 0.84A 4f8hD-4zg8A:
undetectable
4f8hE-4zg8A:
undetectable		 4f8hD-4zg8A:
22.45
4f8hE-4zg8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 GLY A  58
GLY A  57
LEU A  70
ASP A 155
LEU A 147
 None
 1.02A 4fp9D-4zg8A:
undetectable		 4fp9D-4zg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 GLY A  58
GLY A  57
LEU A  70
ASP A 155
LEU A 147
 None
 0.91A 4fzvA-4zg8A:
undetectable		 4fzvA-4zg8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ALA A 207
GLY A 120
GLY A  69
PHE A  68
GLY A 123
 None
 1.15A 4n48B-4zg8A:
undetectable		 4n48B-4zg8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 GLY A 422
GLY A 425
LEU A  16
ILE A 315
ALA A 310
 None
 1.11A 4qtuB-4zg8A:
undetectable		 4qtuB-4zg8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 9 ALA A  87
TYR A  23
SER A  19
ILE A  20
GLY A 425
 None
 1.17A 4r1zA-4zg8A:
undetectable		 4r1zA-4zg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 9 TYR A  23
SER A  19
ILE A  20
GLY A 425
ALA A 428
 None
 1.24A 4r1zA-4zg8A:
undetectable		 4r1zA-4zg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 7 ASN A 413
VAL A 394
ALA A 392
GLY A 351
 None
 0.90A 5fpdA-4zg8A:
undetectable		 5fpdA-4zg8A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ASP A  61
ASP A  64
TYR A 211
SER A 253
GLU A 414
 None
None
None
None
BTB  A 505 (-3.2A)
 1.49A 5iqbA-4zg8A:
0.0		 5iqbA-4zg8A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 11 GLY A 223
GLU A 159
GLY A 158
LEU A 183
ALA A 165
 None
 0.97A 5o96G-4zg8A:
undetectable		 5o96G-4zg8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		5 / 12 ALA A 251
GLY A 158
ALA A 162
SER A 214
THR A  77
 None
None
None
CA  A 501 ( 4.8A)
None
 0.98A 5w4zB-4zg8A:
undetectable		 5w4zB-4zg8A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 4zg8 ENDOGLUCANASE
(Perinereis
brevicirris) 		4 / 7 ASP A 209
ASN A 206
ALA A 207
GLU A 202
 None
None
None
NA  A 506 (-3.4A)
 1.08A 6ci6A-4zg8A:
undetectable		 6ci6A-4zg8A:
10.56