SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		5 / 9 VAL A 356
GLY A 357
ASP A 397
TYR A 435
GLU A 431
 None
 1.13A 1cetA-4zgcA:
undetectable		 1cetA-4zgcA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		4 / 4 GLY A 639
LEU A 647
GLY A 625
ARG A 622
 None
 0.98A 1j7kA-4zgcA:
undetectable		 1j7kA-4zgcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		4 / 6 GLU A 431
TYR A 435
ASP A 397
PHE A 395
 None
None
None
UNX  A 809 ( 3.8A)
 1.35A 2a3bB-4zgcA:
undetectable		 2a3bB-4zgcA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		3 / 3 TRP A 611
ALA A 557
VAL A 555
 None
 0.83A 2izqA-4zgcA:
undetectable
2izqB-4zgcA:
undetectable		 2izqA-4zgcA:
3.69
2izqB-4zgcA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		5 / 9 LEU A 514
ALA A 427
LEU A 429
ALA A 432
PHE A 439
 None
 0.95A 2vcvH-4zgcA:
undetectable		 2vcvH-4zgcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		3 / 3 ALA A 557
VAL A 555
TRP A 611
 None
 0.79A 3l8lA-4zgcA:
undetectable
3l8lB-4zgcA:
undetectable		 3l8lA-4zgcA:
3.69
3l8lB-4zgcA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		5 / 9 ILE A 684
GLY A 674
PHE A 673
VAL A 650
GLY A 638
 None
 1.33A 4acaB-4zgcA:
undetectable
4acaC-4zgcA:
undetectable		 4acaB-4zgcA:
20.40
4acaC-4zgcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		4 / 7 ARG A 404
ILE A 354
PHE A 403
LEU A 368
 None
 1.07A 4mmcA-4zgcA:
undetectable		 4mmcA-4zgcA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		4 / 8 ILE A 723
ASN A 490
LEU A 440
ILE A 416
 None
 0.68A 4r38A-4zgcA:
undetectable		 4r38A-4zgcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		3 / 3 ASN A 672
SER A 624
ARG A 597
 None
 0.83A 5b2qA-4zgcA:
undetectable		 5b2qA-4zgcA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		3 / 3 TYR A 604
ALA A 557
TYR A 541
 None
 0.67A 5uunB-4zgcA:
undetectable		 5uunB-4zgcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4zgc KELCH PROTEIN
(Plasmodium
falciparum) 		4 / 7 ILE A 683
GLU A 461
HIS A 719
VAL A 721
 None
 0.98A 6j20A-4zgcA:
undetectable		 6j20A-4zgcA:
21.03