SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.07A 1c8lA-4zgjB:
undetectable		 1c8lA-4zgjB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.11A 1gfzA-4zgjB:
undetectable		 1gfzA-4zgjB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.12A 1l5qA-4zgjB:
undetectable		 1l5qA-4zgjB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.13A 1l5qB-4zgjB:
undetectable		 1l5qB-4zgjB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.14A 1l7xB-4zgjB:
undetectable		 1l7xB-4zgjB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.12A 3dd1A-4zgjB:
undetectable		 3dd1A-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.11A 3dd1B-4zgjB:
undetectable		 3dd1B-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.13A 3ddsA-4zgjB:
undetectable		 3ddsA-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.12A 3ddsB-4zgjB:
undetectable		 3ddsB-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.12A 3ddwA-4zgjB:
undetectable		 3ddwA-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ASN B  47
HIS B 135
ALA B 162
GLY B 165
 None
 1.12A 3ddwB-4zgjB:
undetectable		 3ddwB-4zgjB:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		3 / 3 VAL B 127
LYS B 128
HIS B 135
 None
 0.84A 3elzA-4zgjB:
undetectable		 3elzA-4zgjB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_B_3QBB203_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		5 / 11 ASP B 160
ARG B  52
ASP B  49
HIS B 135
PHE B 138
 None
 1.04A 4wh5A-4zgjB:
0.2
4wh5B-4zgjB:
0.0		 4wh5A-4zgjB:
20.47
4wh5B-4zgjB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		5 / 10 THR B  78
ALA B  76
SER B  37
MET B  58
GLY B  54
 None
 1.18A 5l66K-4zgjB:
undetectable
5l66L-4zgjB:
undetectable		 5l66K-4zgjB:
22.95
5l66L-4zgjB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		5 / 10 THR B  78
ALA B  76
SER B  37
MET B  58
GLY B  54
 None
 1.19A 5l66Y-4zgjB:
undetectable
5l66Z-4zgjB:
undetectable		 5l66Y-4zgjB:
22.95
5l66Z-4zgjB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		4 / 6 ALA B 161
PRO B 159
PHE B 198
GLU B 171
 None
 1.42A 5odqA-4zgjB:
undetectable		 5odqA-4zgjB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4zgj NITRILE HYDRATASE
BETA SUBUNIT
(Comamonas
testosteroni) 		5 / 12 THR B 136
TYR B 201
PRO B 115
GLU B 166
GLY B 165
 None
 1.39A 6gngB-4zgjB:
undetectable		 6gngB-4zgjB:
16.49