SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4zgp CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 235
ARG A 176
PHE A 175
ILE A 202
LEU A 271
 None
ADP  A 301 (-4.6A)
None
None
None
 1.07A 1drfA-4zgpA:
undetectable		 1drfA-4zgpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4zgp CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 123
LEU A  43
PRO A 102
VAL A 132
 None
 1.10A 2dqyC-4zgpA:
undetectable		 2dqyC-4zgpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4zgp CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 163
LEU A 161
PRO A 102
VAL A 132
 None
 1.12A 2dqyC-4zgpA:
undetectable		 2dqyC-4zgpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4zgp CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 250
SER A 100
PHE A 131
ASP A 135
 None
 1.12A 2vn1B-4zgpA:
undetectable		 2vn1B-4zgpA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4zgp CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 209
PHE A 178
THR A 247
TRP A 254
 None
 1.31A 5g08A-4zgpA:
undetectable		 5g08A-4zgpA:
19.19