SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4zgq EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 GLY B 513
ILE B 512
ALA B 483
ILE B 432
 None
 0.71A 1n49A-4zgqB:
undetectable		 1n49A-4zgqB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 233
ASP A 211
ASN A 201
 None
 0.80A 2bm9D-4zgqA:
undetectable		 2bm9D-4zgqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 123
LEU A  43
PRO A 102
VAL A 132
 None
 1.02A 2dqyC-4zgqA:
undetectable		 2dqyC-4zgqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 163
LEU A 161
PRO A 102
VAL A 132
 None
 1.08A 2dqyC-4zgqA:
undetectable		 2dqyC-4zgqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 250
SER A 100
PHE A 131
ASP A 135
 None
 1.14A 2vn1B-4zgqA:
undetectable		 2vn1B-4zgqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A  42
TYR A  73
GLU A 120
TRP A 107
 None
 1.39A 3cotA-4zgqA:
undetectable		 3cotA-4zgqA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zgq EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 6 ALA B 491
THR B 471
ALA B 473
THR B 488
 None
 1.01A 3mdrB-4zgqB:
undetectable		 3mdrB-4zgqB:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A 104
TRP A 166
SER A 128
 None
 1.05A 4lrhA-4zgqA:
undetectable		 4lrhA-4zgqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 190
ASN A 241
ASP A 135
 None
 0.91A 5gwxA-4zgqA:
undetectable		 5gwxA-4zgqA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 141
PRO A 154
PHE A 146
HIS A  12
ASN A   8
 None
 1.33A 5k7uA-4zgqA:
undetectable		 5k7uA-4zgqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A  94
LYS A  96
ILE A 238
ASP A 239
 None
 0.82A 5yf9B-4zgqA:
undetectable		 5yf9B-4zgqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4zgq CELL DIVISION CYCLE
PROTEIN 123
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 138
ASN A 137
LEU A 136
 None
 0.87A 6f7lB-4zgqA:
undetectable		 6f7lB-4zgqA:
22.61