SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 290
THR A 333
ILE A 234
HIS A 142
ILE A 147
 None
 0.91A 1bx4A-4zgsA:
3.1		 1bx4A-4zgsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 338
TYR A 134
VAL A  86
VAL A  46
 NAD  A1000 (-3.6A)
NAD  A1000 (-4.0A)
None
None
 1.17A 1dz4A-4zgsA:
undetectable		 1dz4A-4zgsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 PHE A 338
TYR A 134
VAL A  86
VAL A  46
 NAD  A1000 (-3.6A)
NAD  A1000 (-4.0A)
None
None
 1.17A 1dz6B-4zgsA:
undetectable		 1dz6B-4zgsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A 301
GLY A 298
ARG A 115
PHE A 302
 None
 1.22A 1gsfA-4zgsA:
undetectable		 1gsfA-4zgsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A 301
GLY A 298
ARG A 115
PHE A 302
 None
 1.22A 1gsfB-4zgsA:
undetectable		 1gsfB-4zgsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 PHE A 301
GLY A 298
ARG A 115
PHE A 302
 None
 1.22A 1gsfD-4zgsA:
undetectable		 1gsfD-4zgsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 ILE A 272
SER A 244
ARG A 246
LEU A 271
 None
NAD  A1000 (-2.1A)
None
None
 1.18A 1y0xX-4zgsA:
undetectable		 1y0xX-4zgsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 9 LEU A 339
TYR A 134
PHE A  85
LEU A 344
HIS A 335
 None
NAD  A1000 (-4.0A)
None
None
NAD  A1000 (-3.8A)
 1.41A 1y7iA-4zgsA:
6.1		 1y7iA-4zgsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 LEU A 339
TYR A 134
PHE A  85
LEU A 344
HIS A 335
 None
NAD  A1000 (-4.0A)
None
None
NAD  A1000 (-3.8A)
 1.41A 1y7iB-4zgsA:
4.7		 1y7iB-4zgsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 ASP A 156
THR A 155
TYR A 158
HIS A 142
 None
 1.36A 2eimN-4zgsA:
undetectable
2eimP-4zgsA:
undetectable		 2eimN-4zgsA:
22.37
2eimP-4zgsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 9 LEU A 228
VAL A 183
THR A 186
ILE A 220
VAL A 215
 None
 1.48A 2l8mA-4zgsA:
undetectable		 2l8mA-4zgsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 PHE A 338
TYR A 134
VAL A  86
VAL A  46
 NAD  A1000 (-3.6A)
NAD  A1000 (-4.0A)
None
None
 1.14A 2m56A-4zgsA:
undetectable		 2m56A-4zgsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 ILE A 196
LEU A 197
VAL A 183
GLY A 190
GLN A 191
 None
 1.26A 2wd9C-4zgsA:
3.7		 2wd9C-4zgsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 ALA A 140
GLN A 192
ILE A 196
ARG A 195
 None
 1.42A 2z0aA-4zgsA:
undetectable		 2z0aA-4zgsA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A 331
ALA A 145
MET A 262
ASN A 151
 None
 1.45A 3uq6A-4zgsA:
4.2		 3uq6A-4zgsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		3 / 3 ASP A  71
ARG A  89
LYS A  70
 None
 1.12A 3wipG-4zgsA:
undetectable		 3wipG-4zgsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 THR A 245
THR A 236
LEU A 228
LEU A 225
 NAD  A1000 (-4.0A)
None
None
None
 1.07A 4lvcB-4zgsA:
5.0		 4lvcB-4zgsA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 ALA A 288
GLY A 287
GLY A 260
GLY A 290
ASN A 151
 None
 1.02A 4obwB-4zgsA:
6.0		 4obwB-4zgsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		3 / 3 ARG A 127
LYS A 369
GLU A 367
 None
 0.80A 5d0yA-4zgsA:
undetectable		 5d0yA-4zgsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 ILE A 264
VAL A 266
ALA A 337
THR A 336
 None
None
NAD  A1000 ( 3.6A)
None
 0.81A 6cduC-4zgsA:
undetectable
6cduD-4zgsA:
undetectable		 6cduC-4zgsA:
21.58
6cduD-4zgsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 290
LEU A 331
VAL A 181
PHE A 148
 None
 0.93A 6h7lA-4zgsA:
undetectable		 6h7lA-4zgsA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4zgs PUTATIVE D-LACTATE
DEHYDROGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 290
LEU A 331
VAL A 181
PHE A 148
 None
 0.93A 6h7lB-4zgsA:
undetectable		 6h7lB-4zgsA:
12.53