SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 ASN A 317
PHE A 324
VAL A 285
 None
 0.63A 1kijA-4zgzA:
undetectable		 1kijA-4zgzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 5 TRP A  55
VAL A  58
GLN A  61
ILE A 234
 None
 1.01A 1ss4A-4zgzA:
undetectable		 1ss4A-4zgzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 4 LEU A 212
PRO A 272
ILE A 268
LEU A 232
 None
 0.88A 1ya4B-4zgzA:
undetectable		 1ya4B-4zgzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 4 LEU A 212
PRO A 272
ILE A 268
LEU A 232
 None
 1.00A 1ya4C-4zgzA:
undetectable		 1ya4C-4zgzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 6 ILE A 364
MET A 384
THR A 282
LEU A 283
 None
 1.03A 2einN-4zgzA:
undetectable
2einW-4zgzA:
undetectable		 2einN-4zgzA:
22.26
2einW-4zgzA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 5 LEU A 232
ILE A  62
SER A 270
GLY A 235
 None
 0.96A 2otfA-4zgzA:
undetectable		 2otfA-4zgzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		4 / 6 ILE A 364
MET A 384
THR A 282
LEU A 283
 None
 1.00A 3ag1N-4zgzA:
undetectable
3ag1W-4zgzA:
undetectable		 3ag1N-4zgzA:
22.26
3ag1W-4zgzA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		5 / 10 TYR A  66
ILE A  79
ILE A  48
GLY A 273
LEU A  77
 None
 1.21A 3elzC-4zgzA:
undetectable		 3elzC-4zgzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		5 / 10 TYR A  66
ILE A  79
ILE A  48
GLY A 273
LEU A  77
 None
 1.22A 3em0A-4zgzA:
undetectable		 3em0A-4zgzA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 THR A  67
LYS A 141
GLU A 271
 None
 0.85A 3ijdB-4zgzA:
8.3		 3ijdB-4zgzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A 168
ILE B 141
PHE B 173
 None
 0.84A 3j7zS-4zgzA:
undetectable
3j7za-4zgzA:
undetectable		 3j7zS-4zgzA:
14.65
3j7za-4zgzA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		3 / 3 GLN A 119
PHE B 218
TYR B 216
 None
 0.84A 3ucjB-4zgzA:
undetectable		 3ucjB-4zgzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		3 / 3 GLN A 119
PHE B 218
TYR B 216
 None
 0.88A 3ucjA-4zgzA:
undetectable		 3ucjA-4zgzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		5 / 11 ALA A  39
GLY A 355
GLY A 319
ASP A 362
ASN A 317
 None
 1.12A 4dcmA-4zgzA:
undetectable		 4dcmA-4zgzA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		5 / 12 SER A 200
ALA A 280
GLN A  54
TYR A 276
GLY A 237
 None
 1.24A 4iilA-4zgzA:
2.2		 4iilA-4zgzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 SER B 191
GLU A  94
ASP A 387
ASN A  71
 None
 1.12A 4pclA-4zgzB:
undetectable		 4pclA-4zgzB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		3 / 3 TYR B 216
TYR A 110
GLN A 119
 None
 1.14A 5jsdA-4zgzB:
undetectable
5jsdB-4zgzB:
undetectable		 5jsdA-4zgzB:
10.53
5jsdB-4zgzB:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		3 / 3 TYR B 216
TYR A 110
GLN A 119
 None
 1.13A 5jsdB-4zgzB:
undetectable
5jsdC-4zgzB:
undetectable		 5jsdB-4zgzB:
10.53
5jsdC-4zgzB:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 SER B 191
GLU A  94
ASP A 387
ASN A  71
 None
 1.10A 5n5dB-4zgzB:
2.0		 5n5dB-4zgzB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 195
HIS A 154
HIS A 197
 None
 1.14A 5oexA-4zgzA:
undetectable		 5oexA-4zgzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 195
HIS A 154
HIS A 197
 None
 1.10A 5oexB-4zgzA:
undetectable		 5oexB-4zgzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 195
HIS A 154
HIS A 197
 None
 1.10A 5oexC-4zgzA:
undetectable		 5oexC-4zgzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens) 		3 / 3 LYS A 195
HIS A 154
HIS A 197
 None
 1.14A 5oexD-4zgzA:
undetectable		 5oexD-4zgzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ASP A 387
ALA A  88
SER A  90
PHE B 192
 None
 1.41A 6cm4A-4zgzA:
undetectable		 6cm4A-4zgzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4zgz ANTIZYME INHIBITOR 1
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens) 		4 / 7 LEU B 187
LEU A 353
GLY A 355
LEU A 361
 None
 0.75A 6eu9D-4zgzB:
undetectable		 6eu9D-4zgzB:
19.33