SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 8 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.74A 1c9sI-4zh7A:
undetectable
1c9sJ-4zh7A:
undetectable		 1c9sI-4zh7A:
8.78
1c9sJ-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 8 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.77A 1c9sU-4zh7A:
undetectable
1c9sV-4zh7A:
undetectable		 1c9sU-4zh7A:
8.78
1c9sV-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 7 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.72A 1gtnA-4zh7A:
undetectable
1gtnK-4zh7A:
undetectable		 1gtnA-4zh7A:
8.78
1gtnK-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 8 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.76A 1gtnE-4zh7A:
undetectable
1gtnF-4zh7A:
undetectable		 1gtnE-4zh7A:
8.78
1gtnF-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 5 PHE A 353
GLY A 338
THR A 349
PHE A 345
 None
 1.29A 1icuC-4zh7A:
undetectable
1icuD-4zh7A:
undetectable		 1icuC-4zh7A:
17.04
1icuD-4zh7A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 6 ALA A 310
LYS A 313
ASP A 317
ALA A 318
 None
 0.35A 1iwhA-4zh7A:
undetectable		 1iwhA-4zh7A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 11 TRP A  97
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.10A 1jb0B-4zh7A:
undetectable		 1jb0B-4zh7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 8 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.74A 1utdI-4zh7A:
undetectable
1utdJ-4zh7A:
undetectable		 1utdI-4zh7A:
8.78
1utdJ-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 12 ILE A 477
THR A 473
LEU A  36
ASN A 524
VAL A 494
 None
 0.96A 2vn0A-4zh7A:
undetectable		 2vn0A-4zh7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 12 SER A 132
SER A 130
THR A 419
VAL A 417
GLN A 161
 None
 1.20A 2x2iA-4zh7A:
undetectable		 2x2iA-4zh7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 12 ILE A  90
ALA A 259
LEU A 174
LEU A 321
LEU A 436
 None
 1.17A 3ix9A-4zh7A:
undetectable		 3ix9A-4zh7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 12 HIS A 331
GLY A  67
ALA A  70
SER A  69
LEU A  73
 None
 1.19A 3n8xA-4zh7A:
undetectable		 3n8xA-4zh7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 11 TRP A  97
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.10A 3pcqB-4zh7A:
undetectable		 3pcqB-4zh7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 9 ILE A 311
LEU A 156
PHE A  96
ILE A 300
ILE A 308
 None
 1.16A 3tq8A-4zh7A:
undetectable		 3tq8A-4zh7A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		4 / 7 PRO A 278
ILE A 300
GLY A 101
VAL A 103
 None
 0.99A 4a3uB-4zh7A:
undetectable		 4a3uB-4zh7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		6 / 12 LEU A  73
LEU A 321
LYS A 366
LEU A 368
ALA A  85
ILE A 440
 None
 1.30A 4x1iD-4zh7A:
undetectable		 4x1iD-4zh7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		6 / 12 LEU A  73
LEU A 321
LYS A 366
LEU A 368
ASN A 369
ALA A  85
 None
 1.12A 4x1iD-4zh7A:
undetectable		 4x1iD-4zh7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 10 TRP A  97
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.14A 4xk8B-4zh7A:
4.1		 4xk8B-4zh7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 10 MET A 314
LEU A 263
ALA A 266
LEU A 163
GLY A  95
 None
 1.30A 5dx3A-4zh7A:
undetectable		 5dx3A-4zh7A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 11 LEU A 263
ALA A  93
ILE A 308
ILE A 378
ILE A 315
 None
 1.26A 5kr2B-4zh7A:
undetectable		 5kr2B-4zh7A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		6 / 12 TRP A  97
ILE A 133
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.08A 5oy02-4zh7A:
5.1		 5oy02-4zh7A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		5 / 12 LEU A 383
ILE A 378
GLY A 375
LEU A 263
LEU A 321
 None
 0.98A 5ycnA-4zh7A:
undetectable		 5ycnA-4zh7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN
(Helicobacter
pylori) 		6 / 10 TRP A  97
ILE A 133
ILE A 311
ALA A  93
LEU A 269
ALA A 159
 None
 1.08A 5zjiB-4zh7A:
undetectable		 5zjiB-4zh7A:
9.70