SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zhj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 TYR A 538
PHE A 599
TYR A 603
HIS A 596
GLY A 579
 None
 1.49A 1aclA-4zhjA:
3.0		 1aclA-4zhjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 898
ALA A 786
PRO A 799
THR A 832
THR A 835
 None
 1.24A 1cbrA-4zhjA:
undetectable		 1cbrA-4zhjA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 898
ALA A 786
PRO A 799
THR A 832
THR A 835
 None
 1.24A 1cbrB-4zhjA:
undetectable		 1cbrB-4zhjA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL A  29
ILE A  84
TYR A  27
LEU A 205
LEU A 201
 None
 0.80A 1cqpA-4zhjA:
4.2
1cqpB-4zhjA:
3.1		 1cqpA-4zhjA:
9.19
1cqpB-4zhjA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A  29
TYR A  27
LEU A 205
LEU A 201
 None
 0.64A 1cqpA-4zhjA:
4.2
1cqpB-4zhjA:
3.1		 1cqpA-4zhjA:
9.19
1cqpB-4zhjA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 201
GLU A 199
ALA A  40
LEU A  38
 None
 1.12A 1eta1-4zhjA:
undetectable		 1eta1-4zhjA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 201
GLU A 199
ALA A  40
LEU A  38
 None
 1.18A 1eta2-4zhjA:
undetectable		 1eta2-4zhjA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A 201
GLU A 199
ALA A  40
LEU A  38
 None
 1.11A 1etb1-4zhjA:
undetectable		 1etb1-4zhjA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 PHE A 461
SER A1289
PHE A 477
ALA A 512
 None
 1.19A 1fxvA-4zhjA:
undetectable
1fxvB-4zhjA:
undetectable		 1fxvA-4zhjA:
9.68
1fxvB-4zhjA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLN A1160
TYR A1125
ARG A1128
 None
 0.90A 1gtbA-4zhjA:
3.3		 1gtbA-4zhjA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A1041
ASP A1044
LEU A1108
ASP A1177
GLY A1100
 None
 1.06A 1ia0B-4zhjA:
undetectable		 1ia0B-4zhjA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 368
VAL A 318
TRP A 323
 None
 1.28A 1qw6A-4zhjA:
undetectable		 1qw6A-4zhjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 983
ALA A 981
LEU A1152
LEU A1183
THR A1158
 None
 0.97A 1qzfA-4zhjA:
2.2		 1qzfA-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 983
ALA A 981
LEU A1152
LEU A1183
THR A1158
 None
 0.96A 1qzfB-4zhjA:
undetectable		 1qzfB-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 983
ALA A 981
LEU A1152
LEU A1183
THR A1158
 None
 0.97A 1qzfC-4zhjA:
undetectable		 1qzfC-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 983
ALA A 981
LEU A1152
LEU A1183
THR A1158
 None
 0.97A 1qzfD-4zhjA:
undetectable		 1qzfD-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A 983
ALA A 981
LEU A1152
LEU A1183
THR A1158
 None
 0.96A 1qzfE-4zhjA:
undetectable		 1qzfE-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 THR A1201
GLN A 999
PHE A1159
ASN A1161
 None
 1.12A 1tt0A-4zhjA:
1.3		 1tt0A-4zhjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 THR A1201
GLN A 999
PHE A1159
ASN A1161
 None
 1.10A 1tt0B-4zhjA:
undetectable		 1tt0B-4zhjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 THR A1201
GLN A 999
PHE A1159
ASN A1161
 None
 1.10A 1tt0C-4zhjA:
undetectable		 1tt0C-4zhjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 THR A1201
GLN A 999
PHE A1159
ASN A1161
 None
 1.11A 1tt0D-4zhjA:
3.4		 1tt0D-4zhjA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL A1041
ASP A1044
LEU A1108
ASP A1177
GLY A1100
 None
 1.06A 1tubB-4zhjA:
undetectable		 1tubB-4zhjA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 TRP A 254
HIS A 238
GLN A 295
PRO A 259
 None
 1.29A 2ez7A-4zhjA:
undetectable		 2ez7A-4zhjA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 9 ARG A1029
GLY A1028
ILE A1032
VAL A 961
VAL A1208
 None
 1.36A 2nnhB-4zhjA:
undetectable		 2nnhB-4zhjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU A1021
ARG A1073
SER A1135
VAL A1087
 None
 1.14A 2qd2A-4zhjA:
4.9		 2qd2A-4zhjA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 PRO A 463
ASN A1288
ARG A1291
 None
 1.05A 2qeuB-4zhjA:
undetectable		 2qeuB-4zhjA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 948
GLY A 994
TYR A 993
PRO A 945
ILE A 990
 None
 1.25A 2y7pA-4zhjA:
2.2		 2y7pA-4zhjA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 913
ALA A 655
GLY A 937
THR A 936
LEU A 910
 None
 0.91A 2zifB-4zhjA:
undetectable		 2zifB-4zhjA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.37A 3dqtA-4zhjA:
undetectable
3dqtB-4zhjA:
undetectable		 3dqtA-4zhjA:
14.52
3dqtB-4zhjA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 696
ILE A 715
PRO A 731
VAL A 728
LEU A 822
 None
 1.39A 3elzB-4zhjA:
undetectable		 3elzB-4zhjA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A  58
VAL A  26
LEU A 108
ILE A  61
VAL A  77
 None
 1.00A 3frqB-4zhjA:
undetectable		 3frqB-4zhjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 667
GLU A 404
ASP A 944
 None
 0.80A 3g2oA-4zhjA:
5.6		 3g2oA-4zhjA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 8 THR A1214
LEU A1217
ALA A1219
ARG A 760
 None
 0.86A 3kp6A-4zhjA:
undetectable		 3kp6A-4zhjA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A  86
VAL A 113
TRP A 193
PHE A 204
 None
 1.33A 3n5tA-4zhjA:
undetectable
3n5tB-4zhjA:
undetectable		 3n5tA-4zhjA:
14.90
3n5tB-4zhjA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 708
GLN A 740
MET A 716
ALA A 735
ASN A 713
 None
 1.31A 3t7sA-4zhjA:
4.1		 3t7sA-4zhjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 708
GLN A 740
MET A 716
ALA A 735
ASN A 713
 None
 1.30A 3t7sB-4zhjA:
undetectable		 3t7sB-4zhjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 708
GLN A 740
MET A 716
ALA A 735
ASN A 713
 None
 1.29A 3t7sC-4zhjA:
3.9		 3t7sC-4zhjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 708
GLN A 740
MET A 716
ALA A 735
ASN A 713
 None
 1.32A 3t7sD-4zhjA:
2.0		 3t7sD-4zhjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 624
GLY A 469
PHE A 626
ASN A 657
 None
 1.21A 3uq6B-4zhjA:
2.8		 3uq6B-4zhjA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 11 ASP A1044
ASN A1107
GLY A 469
SER A1173
GLY A1040
 None
 1.28A 3v3oC-4zhjA:
0.0		 3v3oC-4zhjA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 967
ARG A 752
ASP A 727
 None
 0.87A 3wipG-4zhjA:
undetectable
3wipH-4zhjA:
undetectable		 3wipG-4zhjA:
10.79
3wipH-4zhjA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A 928
ILE A 785
VAL A 901
SER A 774
 None
 0.81A 4acbC-4zhjA:
4.5		 4acbC-4zhjA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 4 ASN A1161
SER A1212
LEU A1211
THR A1201
 None
 1.39A 4an2A-4zhjA:
undetectable		 4an2A-4zhjA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A1101
THR A 470
ILE A 663
SER A 659
HIS A1174
 None
 1.29A 4c49C-4zhjA:
undetectable		 4c49C-4zhjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASN A1107
ILE A 663
ASP A1044
GLY A1040
ASN A1097
 None
 1.16A 4djfA-4zhjA:
undetectable		 4djfA-4zhjA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 PHE A1046
ILE A 948
GLY A 994
THR A 992
 None
 0.89A 4ejjC-4zhjA:
undetectable		 4ejjC-4zhjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A 427
TYR A 174
LEU A 431
GLU A 432
 None
 1.18A 4f3tA-4zhjA:
3.8		 4f3tA-4zhjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 6 ASN A 649
TYR A 602
TYR A 603
LEU A 606
 None
 1.08A 4f8yA-4zhjA:
4.9
4f8yB-4zhjA:
3.3		 4f8yA-4zhjA:
8.81
4f8yB-4zhjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A 602
TYR A 603
LEU A 606
ASN A 649
 None
 1.21A 4f8yC-4zhjA:
3.6
4f8yD-4zhjA:
3.4		 4f8yC-4zhjA:
8.81
4f8yD-4zhjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 890
PHE A 891
ARG A 790
ALA A 838
ALA A 786
 None
 1.23A 4fiaA-4zhjA:
undetectable		 4fiaA-4zhjA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 890
PHE A 891
ARG A 790
ALA A 838
ALA A 786
 None
 1.23A 4fiaA-4zhjA:
undetectable		 4fiaA-4zhjA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 258
HIS A 238
TYR A 255
 None
 1.33A 4fu8A-4zhjA:
undetectable		 4fu8A-4zhjA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.37A 4k5jA-4zhjA:
undetectable
4k5jB-4zhjA:
undetectable		 4k5jA-4zhjA:
14.98
4k5jB-4zhjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A1241
ASP A1171
ASP A1163
 None
 0.88A 4kicB-4zhjA:
undetectable		 4kicB-4zhjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLN A 829
ASP A 727
ARG A 752
SER A 817
LEU A 828
 None
 1.37A 4kmuC-4zhjA:
2.0		 4kmuC-4zhjA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLY A  19
ARG A  20
ALA A  53
LEU A  52
ILE A 112
 None
 0.94A 4kt0A-4zhjA:
undetectable
4kt0J-4zhjA:
undetectable		 4kt0A-4zhjA:
20.12
4kt0J-4zhjA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 ASP A1218
LEU A1217
ARG A 752
THR A1170
 None
 1.45A 4p3qA-4zhjA:
undetectable		 4p3qA-4zhjA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 ARG A 815
ASP A 824
ASP A 830
GLY A 807
ILE A 813
 None
 0.89A 4q1wB-4zhjA:
undetectable		 4q1wB-4zhjA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 MET A1232
TRP A1228
GLU A1242
TYR A1237
 None
 1.47A 4r87J-4zhjA:
undetectable
4r87L-4zhjA:
undetectable		 4r87J-4zhjA:
9.83
4r87L-4zhjA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 838
SER A 873
ALA A 834
SER A 877
ALA A 840
 None
 1.23A 4twdA-4zhjA:
undetectable
4twdB-4zhjA:
undetectable
4twdC-4zhjA:
undetectable
4twdD-4zhjA:
undetectable
4twdE-4zhjA:
undetectable		 4twdA-4zhjA:
12.84
4twdB-4zhjA:
12.84
4twdC-4zhjA:
12.84
4twdD-4zhjA:
12.84
4twdE-4zhjA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 9 ALA A 840
ALA A 838
SER A 873
ALA A 834
SER A 877
 None
 1.21A 4twdA-4zhjA:
undetectable
4twdB-4zhjA:
undetectable
4twdC-4zhjA:
undetectable
4twdD-4zhjA:
undetectable
4twdE-4zhjA:
undetectable		 4twdA-4zhjA:
12.84
4twdB-4zhjA:
12.84
4twdC-4zhjA:
12.84
4twdD-4zhjA:
12.84
4twdE-4zhjA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A1165
THR A 781
ALA A 780
ALA A 680
ASN A 682
 None
 1.24A 4u15A-4zhjA:
undetectable		 4u15A-4zhjA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A1165
THR A 781
ALA A 780
ALA A 680
ASN A 682
 None
 1.30A 4u15B-4zhjA:
undetectable		 4u15B-4zhjA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 4 ILE A 709
ASN A 713
ILE A 715
VAL A 747
 None
 1.11A 4uy87-4zhjA:
undetectable		 4uy87-4zhjA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS A 502
ARG A1241
VAL A1240
 None
 1.05A 4x3uA-4zhjA:
undetectable
4x3uB-4zhjA:
undetectable		 4x3uA-4zhjA:
4.68
4x3uB-4zhjA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A1216
ASP A1261
TRP A1263
 None
 0.97A 4xdqA-4zhjA:
undetectable		 4xdqA-4zhjA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.38A 5adlA-4zhjA:
undetectable
5adlB-4zhjA:
undetectable		 5adlA-4zhjA:
14.98
5adlB-4zhjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 4 ALA A 942
PRO A 921
LEU A 347
HIS A 356
 None
 1.34A 5eskA-4zhjA:
undetectable		 5eskA-4zhjA:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 6 TRP A 985
GLY A 986
SER A1039
VAL A1041
HIS A1174
 None
 0.61A 5ewuA-4zhjA:
59.7		 5ewuA-4zhjA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 6 TRP A 985
GLY A 986
THR A 987
SER A1039
HIS A1174
 None
 0.78A 5ewuA-4zhjA:
59.7		 5ewuA-4zhjA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 6 TRP A 985
GLY A 986
SER A1039
VAL A1041
HIS A1174
 None
 0.55A 5ewuB-4zhjA:
58.0		 5ewuB-4zhjA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 6 TRP A 985
GLY A 986
THR A 987
SER A1039
VAL A1041
 None
 0.86A 5ewuB-4zhjA:
58.0		 5ewuB-4zhjA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.36A 5fj3A-4zhjA:
undetectable
5fj3B-4zhjA:
undetectable		 5fj3A-4zhjA:
14.98
5fj3B-4zhjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE A 409
PRO A 411
VAL A 336
ILE A 273
LEU A 650
 None
 1.19A 5iepA-4zhjA:
undetectable		 5iepA-4zhjA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 PHE A 477
LEU A 521
GLY A 564
ILE A 480
 None
 0.84A 5ik1A-4zhjA:
undetectable		 5ik1A-4zhjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 SER A1212
ALA A1259
GLN A1160
THR A1181
 None
 1.32A 5n0tA-4zhjA:
2.1		 5n0tA-4zhjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 480
ILE A 572
VAL A 570
PHE A 567
GLN A 488
 None
 1.17A 5nukA-4zhjA:
undetectable		 5nukA-4zhjA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 8 TYR A 699
ASP A 739
VAL A 747
GLY A 748
 None
 0.84A 5nzyA-4zhjA:
undetectable		 5nzyA-4zhjA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 ASP A1200
ASP A 926
ASN A 784
ARG A 836
 None
 1.17A 5vooB-4zhjA:
undetectable		 5vooB-4zhjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 235
LYS A 230
LEU A 366
GLY A 274
ILE A 305
 None
 1.07A 5vooD-4zhjA:
undetectable		 5vooD-4zhjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 5 ASP A1200
ASP A 926
ASN A 784
ARG A 836
 None
 1.20A 5vooD-4zhjA:
undetectable		 5vooD-4zhjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.34A 5vv7A-4zhjA:
undetectable
5vv7B-4zhjA:
undetectable		 5vv7A-4zhjA:
14.98
5vv7B-4zhjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.37A 5vvnA-4zhjA:
undetectable
5vvnB-4zhjA:
undetectable		 5vvnA-4zhjA:
14.98
5vvnB-4zhjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR A 677
THR A 936
LEU A 943
ASN A 656
PRO A 658
 None
 1.13A 5ybbB-4zhjA:
undetectable		 5ybbB-4zhjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 11 GLU A 845
ALA A 838
ALA A 840
ILE A 779
VAL A 783
 None
 0.97A 5yk2A-4zhjA:
3.2		 5yk2A-4zhjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A  86
VAL A 113
TRP A 193
PHE A 204
 None
 1.35A 6av6A-4zhjA:
undetectable
6av6B-4zhjA:
0.0		 6av6A-4zhjA:
5.27
6av6B-4zhjA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 TRP A 193
PHE A 204
SER A  86
VAL A 113
 None
 1.37A 6av6C-4zhjA:
undetectable
6av6D-4zhjA:
undetectable		 6av6C-4zhjA:
5.27
6av6D-4zhjA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A  86
VAL A 113
TRP A 193
PHE A 204
 None
 1.38A 6av7A-4zhjA:
0.0
6av7B-4zhjA:
undetectable		 6av7A-4zhjA:
5.27
6av7B-4zhjA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 4 ASP A 988
ALA A 942
SER A 659
PHE A1042
 None
 1.48A 6cm4A-4zhjA:
undetectable		 6cm4A-4zhjA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 165
SER A  86
PHE A 186
PHE A 204
TYR A  34
 None
 1.27A 6drxA-4zhjA:
3.1		 6drxA-4zhjA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 608
ASN A 607
LEU A 606
 None
 0.88A 6f7lB-4zhjA:
2.8		 6f7lB-4zhjA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 667
LYS A 641
TYR A 669
 None
 1.37A 6gnaA-4zhjA:
2.3		 6gnaA-4zhjA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 667
LYS A 641
TYR A 669
 None
 1.37A 6gnbA-4zhjA:
2.3		 6gnbA-4zhjA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4zhj MG-CHELATASE SUBUNIT
CHLH
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A1300
TYR A1265
ASN A1249
GLU A1111
 None
 1.25A 6gneB-4zhjA:
3.2		 6gneB-4zhjA:
16.57