SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		4 / 5 LYS D 111
ALA D 110
ASP D  90
GLY D  93
 None
 1.15A 1e7bA-4zhsD:
0.1		 1e7bA-4zhsD:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 10 GLY D 129
HIS D 130
VAL D 122
ASN D 352
ALA D 356
 None
 0.99A 1likA-4zhsD:
2.9		 1likA-4zhsD:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 10 GLY D 129
HIS D 130
VAL D 122
ASN D 352
ILE D 134
 None
 0.94A 1likA-4zhsD:
2.9		 1likA-4zhsD:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 SER D 108
VAL D 119
LEU D 148
 None
 0.68A 1yajG-4zhsD:
undetectable		 1yajG-4zhsD:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 LYS D 111
TYR D 189
PRO D  89
 None
 1.46A 2j9cC-4zhsD:
1.5		 2j9cC-4zhsD:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 12 ASN D 261
ILE D 332
VAL D 319
PRO D 162
LEU D 274
 None
 1.33A 3a51B-4zhsD:
undetectable		 3a51B-4zhsD:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 ASN D 112
ASP D  90
ARG D 244
 None
 0.84A 3k13A-4zhsD:
undetectable		 3k13A-4zhsD:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 SER D 349
SER D 346
HIS D  29
 None
 0.73A 3mzeA-4zhsD:
undetectable		 3mzeA-4zhsD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		4 / 5 ASN D 112
ALA D 110
PRO D  89
ALA D  91
 None
 1.27A 3twpD-4zhsD:
3.2		 3twpD-4zhsD:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 12 PHE D 104
ASP D  79
ARG D  70
SER D  40
ALA D  91
 None
 1.28A 3ua1A-4zhsD:
undetectable		 3ua1A-4zhsD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 12 LEU D 257
ILE D 173
GLY D 171
PHE D 259
ASN D 261
 None
 1.03A 3uwlB-4zhsD:
undetectable		 3uwlB-4zhsD:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 11 ASN D 352
ALA D 128
VAL D 149
MET D 147
ILE D  82
 None
 1.29A 4j4vA-4zhsD:
undetectable		 4j4vA-4zhsD:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 11 ASN D 352
ALA D 128
VAL D 149
MET D 147
ILE D  82
 None
 1.24A 4j4vD-4zhsD:
undetectable
4j4vE-4zhsD:
undetectable		 4j4vD-4zhsD:
18.42
4j4vE-4zhsD:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 VAL D  37
ALA D  39
PHE D  77
 None
 0.87A 4z4iA-4zhsD:
3.9		 4z4iA-4zhsD:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 12 PRO D 162
ILE D 322
GLY D 320
LEU D 159
ALA D 255
 None
 0.91A 5h5fA-4zhsD:
undetectable		 5h5fA-4zhsD:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		3 / 3 VAL D  37
ALA D  39
PHE D  77
 None
 0.89A 5js1A-4zhsD:
undetectable		 5js1A-4zhsD:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 12 VAL D 122
PRO D 290
GLU D 312
GLU D 280
TYR D 277
 None
 1.33A 5mqtC-4zhsD:
2.0		 5mqtC-4zhsD:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 10 TYR D 277
LEU D 166
ASN D 127
LEU D 159
LEU D 220
 None
 1.18A 5y7pB-4zhsD:
undetectable		 5y7pB-4zhsD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		5 / 10 TYR D 277
LEU D 166
ASN D 127
LEU D 159
LEU D 220
 None
 1.20A 5y7pH-4zhsD:
undetectable		 5y7pH-4zhsD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Trichophyton
rubrum) 		4 / 8 ALA D 255
GLY D 158
LEU D 159
ALA D 163
 None
 0.72A 6mdqA-4zhsD:
undetectable		 6mdqA-4zhsD:
12.14