SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 VAL A 367
LEU A 371
VAL A  14
ILE A 108
ILE A 106
 None
 1.01A 1epbA-4zhtA:
undetectable		 1epbA-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 PHE A 276
ILE A 241
LEU A 344
ALA A 217
ILE A 215
 None
 1.03A 1epbB-4zhtA:
undetectable		 1epbB-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 VAL A 367
LEU A 371
VAL A  14
ILE A 108
ILE A 106
 None
 1.03A 1epbB-4zhtA:
undetectable		 1epbB-4zhtA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 325
SER A 139
SER A 302
LYS A  24
 None
None
UDP  A 501 (-2.5A)
UDP  A 501 (-3.1A)
 1.22A 1hwkC-4zhtA:
undetectable		 1hwkC-4zhtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 325
SER A 139
SER A 302
LYS A  24
 None
None
UDP  A 501 (-2.5A)
UDP  A 501 (-3.1A)
 1.21A 1hwkD-4zhtA:
undetectable		 1hwkD-4zhtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 5 LEU A  10
VAL A  12
CYH A  13
ALA A  15
 None
 1.17A 1mz9D-4zhtA:
undetectable		 1mz9D-4zhtA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 4 LEU A  10
VAL A  12
CYH A  13
ALA A  15
 None
 1.29A 1mz9E-4zhtA:
undetectable		 1mz9E-4zhtA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 7 PHE A 284
PHE A 287
SER A 302
ARG A 306
 UDP  A 501 (-4.8A)
UDP  A 501 (-3.4A)
UDP  A 501 (-2.5A)
None
 1.49A 1rqpB-4zhtA:
undetectable		 1rqpB-4zhtA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 8 LEU A 205
TRP A 204
LEU A 290
TYR A 214
 None
 1.02A 1s1xA-4zhtA:
2.3		 1s1xA-4zhtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
 None
 1.45A 2fj1A-4zhtA:
undetectable		 2fj1A-4zhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 LEU A  92
VAL A  12
VAL A 109
ILE A 128
 None
 1.22A 2hyyB-4zhtA:
undetectable		 2hyyB-4zhtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
 None
 1.49A 2o7oA-4zhtA:
undetectable		 2o7oA-4zhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 7 ILE A 254
ARG A  77
ILE A  75
PHE A 114
 None
 1.04A 2q6hA-4zhtA:
undetectable		 2q6hA-4zhtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 7 PHE A 284
PHE A 287
SER A 302
ARG A 306
 UDP  A 501 (-4.8A)
UDP  A 501 (-3.4A)
UDP  A 501 (-2.5A)
None
 1.48A 2v7uB-4zhtA:
undetectable		 2v7uB-4zhtA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
 None
 1.37A 2xpvA-4zhtA:
undetectable		 2xpvA-4zhtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 SER A 229
GLU A  81
ASP A 225
 None
 0.85A 2zthA-4zhtA:
2.4		 2zthA-4zhtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 SER A 229
GLU A  81
ASP A 225
 None
 0.75A 3bwmA-4zhtA:
2.5		 3bwmA-4zhtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 SER A 229
GLU A  81
ASP A 225
 None
 0.82A 3bwyA-4zhtA:
2.4		 3bwyA-4zhtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 LEU A  92
VAL A  12
VAL A 109
ILE A 128
 None
 1.19A 3k5vA-4zhtA:
undetectable		 3k5vA-4zhtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 LEU A  92
VAL A  12
VAL A 109
ILE A 128
 None
 1.18A 3k5vB-4zhtA:
undetectable		 3k5vB-4zhtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 THR A 141
GLN A 322
ILE A 254
SER A 139
 None
 1.26A 3peoG-4zhtA:
undetectable		 3peoG-4zhtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 LYS A 212
ASP A 213
TYR A 214
LYS A 245
 None
 1.26A 3pocB-4zhtA:
2.9		 3pocB-4zhtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 6 ILE A 316
LEU A 332
ARG A 321
THR A 320
 None
None
UDP  A 501 (-3.1A)
None
 1.06A 3wg7A-4zhtA:
undetectable
3wg7J-4zhtA:
undetectable		 3wg7A-4zhtA:
20.56
3wg7J-4zhtA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 8 SER A 139
ASP A 144
VAL A 222
THR A 224
 None
 1.13A 4lnwA-4zhtA:
undetectable		 4lnwA-4zhtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 LEU A  41
ILE A  32
ILE A  28
ALA A  15
ILE A  61
 None
 1.05A 4nkxA-4zhtA:
undetectable		 4nkxA-4zhtA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 HIS A 110
SER A  23
GLU A 134
GLY A 182
PRO A 184
 None
UDP  A 501 (-2.8A)
None
None
None
 1.28A 4uilH-4zhtA:
undetectable
4uilL-4zhtA:
undetectable		 4uilH-4zhtA:
20.89
4uilL-4zhtA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 321
ARG A 325
VAL A 138
ASP A 143
 UDP  A 501 (-3.1A)
None
None
None
 1.17A 4xqgA-4zhtA:
5.4		 4xqgA-4zhtA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		3 / 3 SER A 229
GLU A  81
ASP A 225
 None
 0.82A 4xudA-4zhtA:
2.2		 4xudA-4zhtA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 7 VAL A 249
PHE A 276
HIS A 273
GLU A 271
 None
None
None
NCC  A 502 (-2.7A)
 1.35A 5ad9A-4zhtA:
undetectable
5ad9B-4zhtA:
undetectable		 5ad9A-4zhtA:
21.68
5ad9B-4zhtA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 VAL A  12
ILE A 370
PRO A 184
LEU A  25
VAL A  14
 None
 1.11A 5im2A-4zhtA:
undetectable		 5im2A-4zhtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 7 SER A 229
ILE A 142
GLU A  81
ASP A 225
 None
 0.92A 5n5dA-4zhtA:
2.8		 5n5dA-4zhtA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 4 SER A  87
THR A 223
ASP A 225
ASP A  80
 None
 1.00A 5vimA-4zhtA:
undetectable		 5vimA-4zhtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		4 / 4 SER A  87
THR A 223
ASP A 225
ASP A  80
 None
 1.02A 5vimB-4zhtA:
undetectable		 5vimB-4zhtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 10 LEU A 117
ALA A 118
LEU A  92
ILE A  75
LEU A  46
 None
 1.26A 6cbzB-4zhtA:
undetectable		 6cbzB-4zhtA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens) 		5 / 12 GLY A 299
LEU A 218
VAL A 216
GLY A 140
ASP A 143
 None
UDP  A 501 (-4.3A)
None
None
None
 1.12A 6gngA-4zhtA:
14.1		 6gngA-4zhtA:
21.97