SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4zi5 P91
(metagenome) 		5 / 12 LEU A  98
ALA A 132
LEU A 134
ILE A 115
ILE A 137
 None
 0.94A 1fk6A-4zi5A:
undetectable		 1fk6A-4zi5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4zi5 P91
(metagenome) 		5 / 12 PHE A 119
ILE A 115
GLY A 142
SER A 200
PRO A  36
 None
 1.22A 1sg9A-4zi5A:
undetectable		 1sg9A-4zi5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4zi5 P91
(metagenome) 		4 / 7 LYS A  46
ASN A  42
PRO A  36
ALA A  45
 None
 1.35A 2ejgB-4zi5A:
undetectable		 2ejgB-4zi5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4zi5 P91
(metagenome) 		4 / 8 VAL A  33
VAL A 112
ALA A 128
GLN A  95
 None
 1.03A 2ij7C-4zi5A:
undetectable		 2ij7C-4zi5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4zi5 P91
(metagenome) 		4 / 5 LEU A 231
ALA A 113
ILE A 137
SER A 157
 None
 1.06A 2othA-4zi5A:
undetectable		 2othA-4zi5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4zi5 P91
(metagenome) 		4 / 6 ALA A 218
ASP A 217
GLU A 221
ARG A  51
 None
 1.13A 2ouzA-4zi5A:
undetectable		 2ouzA-4zi5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4zi5 P91
(metagenome) 		4 / 7 ARG A   4
GLU A  18
ALA A  58
ALA A  59
 None
 0.93A 2zgwA-4zi5A:
undetectable		 2zgwA-4zi5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4zi5 P91
(metagenome) 		5 / 12 ALA A  59
ALA A  68
GLY A  17
LEU A 101
TYR A   8
 None
 1.20A 2zifB-4zi5A:
2.1		 2zifB-4zi5A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4zi5 P91
(metagenome) 		5 / 12 ASP A  10
ASP A  63
GLY A 120
LEU A  41
ILE A  80
 None
 1.11A 3pwwA-4zi5A:
undetectable		 3pwwA-4zi5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4zi5 P91
(metagenome) 		5 / 12 LEU A  60
ALA A  62
LEU A  98
ILE A 137
LEU A 134
 None
 1.17A 4j24D-4zi5A:
undetectable		 4j24D-4zi5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4zi5 P91
(metagenome) 		4 / 8 HIS A 209
ALA A  38
SER A 200
ASP A 203
 None
 0.95A 4k0bB-4zi5A:
undetectable		 4k0bB-4zi5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4zi5 P91
(metagenome) 		4 / 8 HIS A 209
ALA A  38
SER A 200
ASP A 203
 None
 0.97A 4l7iB-4zi5A:
undetectable		 4l7iB-4zi5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4zi5 P91
(metagenome) 		3 / 3 ASP A 167
TRP A  90
SER A 200
 None
 0.85A 4lrhA-4zi5A:
undetectable		 4lrhA-4zi5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4zi5 P91
(metagenome) 		5 / 12 MET A  64
LEU A  60
PHE A  35
THR A 123
THR A 102
 None
 1.30A 5bykA-4zi5A:
undetectable		 5bykA-4zi5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zi5 P91
(metagenome) 		4 / 8 PHE A 236
GLY A  31
LEU A  98
LEU A 127
 None
 0.86A 5hs1A-4zi5A:
undetectable		 5hs1A-4zi5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4zi5 P91
(metagenome) 		4 / 4 HIS A  65
GLY A  66
ARG A  93
THR A  13
 None
 1.02A 5nn4A-4zi5A:
undetectable		 5nn4A-4zi5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4zi5 P91
(metagenome) 		4 / 6 PHE A  39
PHE A  71
ILE A  80
THR A  79
 None
 1.14A 5vceA-4zi5A:
undetectable		 5vceA-4zi5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4zi5 P91
(metagenome) 		5 / 12 MET A  64
LEU A  60
PHE A  35
THR A 123
THR A 102
 None
 1.24A 6b54A-4zi5A:
undetectable		 6b54A-4zi5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4zi5 P91
(metagenome) 		5 / 12 PHE A 117
LEU A 134
THR A 123
GLY A 121
MET A  64
 None
 1.42A 6brdA-4zi5A:
undetectable		 6brdA-4zi5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4zi5 P91
(metagenome) 		5 / 12 PHE A 182
VAL A 178
THR A 139
VAL A 159
ALA A 132
 None
 1.15A 6djzA-4zi5A:
undetectable		 6djzA-4zi5A:
23.93