SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		5 / 10 VAL A 134
PHE A  46
VAL A  76
VAL A  95
ILE A  98
 None
 1.13A 1fe2A-4zi8A:
undetectable		 1fe2A-4zi8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		5 / 12 GLN A 293
PHE A 214
VAL A 236
VAL A 250
LEU A 267
 None
 1.05A 1z9yA-4zi8A:
undetectable		 1z9yA-4zi8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 8 ILE A 200
PHE A 150
LEU A 166
PHE A 124
 None
 0.96A 2vdbA-4zi8A:
undetectable		 2vdbA-4zi8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 6 LEU A 187
GLU A 143
SER A 195
THR A 197
 None
 1.43A 3ropA-4zi8A:
undetectable		 3ropA-4zi8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 7 ASP A 133
ASP A  97
GLU A  65
ARG A  11
 CA  A 405 ( 3.2A)
CA  A 405 (-2.9A)
CA  A 405 ( 2.2A)
None
 0.98A 3s3oA-4zi8A:
undetectable		 3s3oA-4zi8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 7 ASP A 173
ASP A 209
ASN A 210
GLU A 116
 CA  A 402 (-3.1A)
CA  A 402 ( 2.6A)
CA  A 403 (-4.9A)
CA  A 402 ( 2.9A)
 1.03A 4feuB-4zi8A:
undetectable		 4feuB-4zi8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 8 ASP A 173
ASP A 209
ASN A 210
GLU A 116
 CA  A 402 (-3.1A)
CA  A 402 ( 2.6A)
CA  A 403 (-4.9A)
CA  A 402 ( 2.9A)
 1.16A 4fewF-4zi8A:
undetectable		 4fewF-4zi8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4zi8 PROTEIN PCDHGC3
(Mus
musculus) 		4 / 6 GLU A 302
ASP A 240
ASP A 242
GLU A 175
 None
CA  A 401 (-2.2A)
CA  A 403 ( 3.3A)
CA  A 403 ( 2.4A)
 1.30A 4ntxA-4zi8A:
undetectable
4ntxC-4zi8A:
undetectable		 4ntxA-4zi8A:
23.03
4ntxC-4zi8A:
16.51