SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zi9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		4 / 6 LEU A  46
ILE A  95
GLU A   9
ASP A  63
 None
None
CA  A 504 ( 2.8A)
CA  A 506 (-3.1A)
 1.15A 1ditH-4zi9A:
undetectable
1ditP-4zi9A:
undetectable		 1ditH-4zi9A:
23.19
1ditP-4zi9A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		5 / 10 PHE A 253
ASP A 267
VAL A 236
MET A 289
LEU A 273
 None
 1.41A 3eqmA-4zi9A:
undetectable		 3eqmA-4zi9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		4 / 8 ASP A 177
VAL A 204
PHE A 150
LEU A 168
 None
 1.08A 4f8hB-4zi9A:
undetectable
4f8hC-4zi9A:
undetectable		 4f8hB-4zi9A:
20.90
4f8hC-4zi9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		4 / 8 ASP A 177
VAL A 204
PHE A 150
LEU A 168
 None
 1.10A 4f8hC-4zi9A:
undetectable
4f8hD-4zi9A:
undetectable		 4f8hC-4zi9A:
20.90
4f8hD-4zi9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		4 / 7 ASP A  63
ASP A 100
ASN A 101
GLU A   9
 CA  A 506 (-3.1A)
CA  A 506 ( 2.7A)
CA  A 504 (-4.9A)
CA  A 504 ( 2.8A)
 1.12A 4feuB-4zi9A:
undetectable		 4feuB-4zi9A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		4 / 4 HIS A 180
ALA A 178
VAL A 204
GLU A 175
 None
None
None
CA  A 502 ( 2.2A)
 1.08A 4n6pA-4zi9A:
undetectable		 4n6pA-4zi9A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		5 / 11 PHE A 253
ASP A 267
VAL A 236
MET A 289
LEU A 273
 None
 1.38A 5jkwA-4zi9A:
undetectable		 5jkwA-4zi9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		5 / 10 PHE A 253
ASP A 267
VAL A 236
MET A 289
LEU A 273
 None
 1.39A 5jl7A-4zi9A:
undetectable		 5jl7A-4zi9A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		3 / 3 LEU A  46
LEU A  67
ARG A  43
 None
 0.69A 6fgcA-4zi9A:
undetectable		 6fgcA-4zi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4zi9 MCG133388, ISOFORM
CRA_T
(Mus
musculus) 		3 / 3 LEU A  46
LEU A  67
ARG A  43
 None
 0.68A 6fgdA-4zi9A:
undetectable		 6fgdA-4zi9A:
23.26