SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK2_A_ACAA91_1 (TISSUE-TYPE PLASMINOGEN ACTIVATOR)	4zih	APOPTOSIS REGULATOR BAX (Homo sapiens)	4 / 8	TYR A 115 ASP A 71 ASP A 68 LEU A 27	None	1.13A	1pk2A-4zihA: undetectable	1pk2A-4zihA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_A_RIMA199_1 (MATRIX PROTEIN 2)	4zih	APOPTOSIS REGULATOR BAX (Homo sapiens)	4 / 6	LEU A 63 LEU A 59 ILE A 66 ARG A 65	None	0.87A	2rlfA-4zihA: undetectable 2rlfB-4zihA: undetectable	2rlfA-4zihA: 14.29 2rlfB-4zihA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H2F_A_ADNA601_1 (5'-NUCLEOTIDASE)	4zih	APOPTOSIS REGULATOR BAX BCL-2-LIKE PROTEIN 11 (Homo sapiens)	5 / 9	ASN A 106 GLY A 108 PHE A 100 GLY B 156 ASP B 157	None	1.36A	4h2fA-4zihA: undetectable	4h2fA-4zihA: 14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H2G_A_ADNA603_1 (5'-NUCLEOTIDASE)	4zih	APOPTOSIS REGULATOR BAX BCL-2-LIKE PROTEIN 11 (Homo sapiens)	5 / 9	ASN A 106 GLY A 108 PHE A 100 GLY B 156 ASP B 157	None	1.42A	4h2gA-4zihA: undetectable	4h2gA-4zihA: 14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VW4_A_NCAA403_0 (FERREDOXIN--NADP REDUCTASE)	4zih	APOPTOSIS REGULATOR BAX (Homo sapiens)	5 / 9	THR A 22 GLY A 23 ALA A 24 LEU A 59 SER A 60	None	1.25A	5vw4A-4zihA: undetectable	5vw4A-4zihA: 19.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PK2_A_ACAA91_1","TISSUE-TYPE PLASMINOGEN ACTIVATOR","4zih","APOPTOSIS REGULATOR BAX","Homo sapiens",4,"TYR A 115;ASP A  71;ASP A  68;LEU A  27","None","1.13A","1pk2A-4zihA:undetectable","1pk2A-4zihA:18.45"],["2RLF_A_RIMA199_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","4zih","APOPTOSIS REGULATOR BAX","Homo sapiens",4,"LEU A  63;LEU A  59;ILE A  66;ARG A  65","None","0.87A","2rlfA-4zihA:undetectable;2rlfB-4zihA:undetectable","2rlfA-4zihA:14.29;2rlfB-4zihA:14.29"],["4H2F_A_ADNA601_1","5'-NUCLEOTIDASE","4zih","APOPTOSIS REGULATOR BAX;BCL-2-LIKE PROTEIN 11","Homo sapiens",5,"ASN A 106;GLY A 108;PHE A 100;GLY B 156;ASP B 157","None","1.36A","4h2fA-4zihA:undetectable","4h2fA-4zihA:14.84"],["4H2G_A_ADNA603_1","5'-NUCLEOTIDASE","4zih","APOPTOSIS REGULATOR BAX;BCL-2-LIKE PROTEIN 11","Homo sapiens",5,"ASN A 106;GLY A 108;PHE A 100;GLY B 156;ASP B 157","None","1.42A","4h2gA-4zihA:undetectable","4h2gA-4zihA:14.84"],["5VW4_A_NCAA403_0","FERREDOXIN--NADP REDUCTASE","4zih","APOPTOSIS REGULATOR BAX","Homo sapiens",5,"THR A  22;GLY A  23;ALA A  24;LEU A  59;SER A  60","None","1.25A","5vw4A-4zihA:undetectable","5vw4A-4zihA:19.00"]]