SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 11 CYH A1004
LEU A1146
LEU A1126
CYH A1133
ILE A1149
 None
 1.40A 1ee2A-4zj8A:
4.1		 1ee2A-4zj8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 11 LEU A1126
GLU A1130
ALA A1136
GLY A1110
TYR A1109
 None
 1.32A 1l5rA-4zj8A:
21.1		 1l5rA-4zj8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 PHE A1069
LEU A1086
PHE A1064
VAL A1093
ALA A1054
 None
 1.13A 1q23H-4zj8A:
undetectable
1q23I-4zj8A:
undetectable		 1q23H-4zj8A:
16.07
1q23I-4zj8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 VAL A 132
ALA A  91
GLN A 126
VAL A  95
ASP A  92
 None
None
SUV  A2001 (-3.8A)
None
None
 1.26A 1td2A-4zj8A:
3.4		 1td2A-4zj8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 LEU A1012
GLY A1014
SER A1022
LEU A1023
SER A1111
 None
 1.28A 3gyqA-4zj8A:
3.6
3gyqB-4zj8A:
undetectable		 3gyqA-4zj8A:
20.00
3gyqB-4zj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 ALA A1128
GLY A1155
ILE A1156
VAL A1143
LEU A1146
 None
 1.04A 3ogpA-4zj8A:
undetectable		 3ogpA-4zj8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 TYR A 311
ILE A 314
VAL A 130
LEU A 135
SER A 138
 None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
None
None
 1.18A 3w67C-4zj8A:
undetectable		 3w67C-4zj8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
 None
 1.45A 4a79A-4zj8A:
undetectable		 4a79A-4zj8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 LEU A1058
LEU A1051
ILE A1170
PHE A1037
TYR A1120
 None
 1.39A 4a79B-4zj8A:
undetectable		 4a79B-4zj8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 11 SER A 164
ILE A 168
TRP A 169
LEU A  94
TYR A 311
 None
 1.31A 4fogA-4zj8A:
undetectable		 4fogA-4zj8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		3 / 3 GLU A 204
ARG A 322
HIS A 216
 SUV  A2001 (-4.4A)
None
SUV  A2001 ( 4.8A)
 0.82A 4kf9A-4zj8A:
undetectable		 4kf9A-4zj8A:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		10 / 12 VAL A 106
TRP A 112
GLN A 126
VAL A 130
GLN A 179
GLU A 204
ILE A 314
ASN A 318
HIS A 344
TYR A 348
 SUV  A2001 (-4.5A)
None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
SUV  A2001 (-3.3A)
SUV  A2001 (-4.4A)
SUV  A2001 (-3.8A)
SUV  A2001 (-2.9A)
SUV  A2001 (-3.5A)
SUV  A2001 (-4.8A)
 0.52A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 5 ILE A 122
PRO A 123
HIS A 216
TYR A 311
VAL A 347
 SUV  A2001 ( 4.8A)
SUV  A2001 (-3.9A)
SUV  A2001 ( 4.8A)
None
SUV  A2001 ( 4.6A)
 0.34A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		4 / 4 GLY A1039
VAL A1048
PHE A1035
ILE A1116
 None
 1.11A 4xv2B-4zj8A:
0.5		 4xv2B-4zj8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 PHE A 139
ILE A 168
TRP A 169
LEU A  94
ALA A 127
 None
None
None
None
SUV  A2001 ( 4.5A)
 1.46A 5fctB-4zj8A:
undetectable		 5fctB-4zj8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 10 PRO A1163
ALA A1140
GLY A1155
ILE A1150
ALA A1142
 None
 1.29A 5vyhA-4zj8A:
undetectable		 5vyhA-4zj8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi) 		5 / 12 VAL A1105
GLY A1047
ARG A1040
PRO A1123
GLY A1125
 None
 1.20A 6brdC-4zj8A:
undetectable		 6brdC-4zj8A:
11.06