SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		5 / 10 LEU A 135
VAL A 103
ASP A 134
ALA A  80
ASN A 247
 None
GOL  A 408 (-4.2A)
None
None
None
 1.44A 1fpqA-4zjgA:
undetectable		 1fpqA-4zjgA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 6 LEU A  83
LYS A 157
GLN A  95
ILE A 101
 None
PG4  A 401 (-2.8A)
None
None
 1.13A 2jn3A-4zjgA:
undetectable		 2jn3A-4zjgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.08A 2zj0B-4zjgA:
undetectable		 2zj0B-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 0.95A 2zj0C-4zjgA:
undetectable		 2zj0C-4zjgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.02A 3ce6B-4zjgA:
undetectable		 3ce6B-4zjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 1.02A 3ce6D-4zjgA:
undetectable		 3ce6D-4zjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		5 / 12 LEU A 352
THR A 361
VAL A 267
ILE A 211
THR A 288
 None
 1.11A 3czhB-4zjgA:
undetectable		 3czhB-4zjgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 5 LEU A 344
GLN A 333
THR A 332
HIS A 341
 None
None
None
PGE  A 402 (-4.2A)
 0.98A 3n58C-4zjgA:
undetectable		 3n58C-4zjgA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 7 ILE A 319
GLN A 316
GLY A 293
VAL A 294
 None
 0.99A 4a3uB-4zjgA:
undetectable		 4a3uB-4zjgA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4zjg ALPHA-2-MACROGLOBULI
N
(Escherichia
coli) 		4 / 8 GLU A 116
HIS A 128
GLN A  76
GLY A  79
 None
 0.94A 4f93B-4zjgA:
undetectable		 4f93B-4zjgA:
12.28