SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		5 / 12 GLY A  95
ILE A 117
ALA A  97
PHE A 126
SER A 125
 NAD  A 300 (-3.7A)
None
None
None
None
 1.21A 1ri4A-4zjuA:
5.1		 1ri4A-4zjuA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		4 / 5 GLY A  86
TRP A  84
ARG A  10
LEU A 136
 None
 1.46A 2j2pD-4zjuA:
undetectable
2j2pF-4zjuA:
undetectable		 2j2pD-4zjuA:
21.91
2j2pF-4zjuA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		4 / 4 ILE A  22
ARG A 221
ILE A 195
THR A 148
 NAD  A 300 (-3.9A)
None
NAD  A 300 (-4.5A)
None
 1.26A 3ia4C-4zjuA:
undetectable		 3ia4C-4zjuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		4 / 8 PHE A  63
ALA A  76
VAL A  90
VAL A  87
 None
 0.90A 3me6B-4zjuA:
undetectable		 3me6B-4zjuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		3 / 3 TYR A 124
ASP A  70
ASP A  66
 None
None
NAD  A 300 (-3.7A)
 0.83A 4a6eA-4zjuA:
5.0		 4a6eA-4zjuA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		5 / 12 ALA A  29
ARG A  32
ALA A 231
LEU A 147
ILE A 190
 None
None
None
NAD  A 300 (-4.0A)
None
 1.16A 4lnwA-4zjuA:
undetectable		 4lnwA-4zjuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		5 / 12 ALA A  29
ARG A  32
ALA A 231
LEU A 147
ILE A 190
 None
None
None
NAD  A 300 (-4.0A)
None
 1.16A 4lnxA-4zjuA:
undetectable		 4lnxA-4zjuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		4 / 6 GLU A  79
GLY A 142
ASP A  88
ARG A 140
 None
 0.74A 5cdnR-4zjuA:
undetectable
5cdnS-4zjuA:
3.1		 5cdnR-4zjuA:
18.80
5cdnS-4zjuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		5 / 9 ARG A  32
ALA A  27
GLN A  28
ILE A  13
PHE A  11
 None
 1.28A 5i73A-4zjuA:
undetectable		 5i73A-4zjuA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4zju ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Acinetobacter
baumannii) 		5 / 12 GLY A  25
GLU A 227
ALA A 232
PHE A  57
ALA A  29
 None
 1.17A 5n5dA-4zjuA:
7.3		 5n5dA-4zjuA:
23.25