SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 6 LEU A 107
ILE A 168
ARG A 144
VAL A 134
 None
 1.00A 1db1A-4zk3A:
undetectable		 1db1A-4zk3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 ALA A  45
LEU A 314
LEU A 325
ALA A  37
ILE A  53
 None
 1.22A 1g5yB-4zk3A:
undetectable		 1g5yB-4zk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 11 LEU A 176
ALA A 122
MET A 317
LEU A 323
HIS A  82
 None
 1.48A 1kt6A-4zk3A:
undetectable		 1kt6A-4zk3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 11 PHE A  13
PHE A  16
LEU A 224
VAL A 227
VAL A 231
 None
 1.43A 1q23J-4zk3A:
undetectable		 1q23J-4zk3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 8 ASN A   8
PHE A  59
SER A  36
ALA A   7
 None
 1.19A 1rqpC-4zk3A:
undetectable		 1rqpC-4zk3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 4 LEU A 246
VAL A 245
ILE A 244
TRP A 269
 None
 1.21A 1s9qB-4zk3A:
undetectable		 1s9qB-4zk3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 LEU A 284
GLU A 339
GLY A 340
ALA A 341
ALA A 343
 None
 1.12A 2bm9A-4zk3A:
undetectable		 2bm9A-4zk3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 LEU A 284
GLU A 339
GLY A 340
ALA A 341
ALA A 343
 None
 0.96A 2bm9D-4zk3A:
undetectable		 2bm9D-4zk3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4zk3 SERPIN B3
(Homo
sapiens) 		6 / 12 PHE A 383
ILE A 159
ALA A 345
ALA A 343
LEU A 241
TYR A 236
 None
 1.36A 2fr3A-4zk3A:
undetectable		 2fr3A-4zk3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		6 / 12 ALA A  37
GLY A  39
THR A 347
SER A  33
MET A 304
GLY A 303
 None
 1.09A 2hw2A-4zk3A:
undetectable		 2hw2A-4zk3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 SER A  30
LEU A 101
PHE A  92
ALA A 179
THR A 155
 None
 1.28A 2v0mC-4zk3A:
undetectable		 2v0mC-4zk3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 11 SER A  30
LEU A 101
ILE A 180
PHE A 182
ALA A 343
 None
 1.38A 2v0mD-4zk3A:
undetectable		 2v0mD-4zk3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 7 ILE A 307
LEU A 325
PHE A 308
THR A  35
 None
 0.96A 3ag2N-4zk3A:
undetectable
3ag2W-4zk3A:
undetectable		 3ag2N-4zk3A:
20.65
3ag2W-4zk3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 7 ILE A 307
LEU A 325
PHE A 308
THR A  35
 None
 0.97A 3ag4N-4zk3A:
undetectable
3ag4W-4zk3A:
undetectable		 3ag4N-4zk3A:
20.65
3ag4W-4zk3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4zk3 SERPIN B3
(Homo
sapiens) 		3 / 3 PHE A 369
CYH A 365
PHE A 200
 None
 1.13A 3cr5X-4zk3A:
undetectable		 3cr5X-4zk3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 LEU A 174
GLY A 327
GLY A 351
ALA A 348
LEU A 299
 None
 1.08A 3dh0B-4zk3A:
undetectable		 3dh0B-4zk3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 10 LEU A 314
VAL A 349
ALA A  50
ILE A  53
LEU A  38
 None
 1.24A 3fl9A-4zk3A:
undetectable		 3fl9A-4zk3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 6 GLN A 255
LEU A 257
GLU A 258
LEU A 370
 None
 0.92A 3h5gA-4zk3A:
undetectable
3h5gC-4zk3A:
undetectable		 3h5gA-4zk3A:
6.16
3h5gC-4zk3A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 5 LEU A 101
TYR A 236
ILE A 373
ALA A 343
 None
 0.86A 3n8yB-4zk3A:
undetectable		 3n8yB-4zk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4zk3 SERPIN B3
(Homo
sapiens) 		3 / 3 LYS A 106
SER A 153
GLN A 154
 None
 1.38A 3si7A-4zk3A:
undetectable		 3si7A-4zk3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 LEU A 107
SER A 315
TYR A 119
LEU A 174
THR A 318
 None
 1.42A 3thrA-4zk3A:
undetectable
3thrB-4zk3A:
0.5
3thrC-4zk3A:
undetectable
3thrD-4zk3A:
0.8		 3thrA-4zk3A:
20.60
3thrB-4zk3A:
20.60
3thrC-4zk3A:
20.60
3thrD-4zk3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zk3 SERPIN B3
(Homo
sapiens) 		3 / 3 THR A 172
VAL A 175
GLU A 110
 None
 0.78A 3v4tA-4zk3A:
undetectable
3v4tD-4zk3A:
undetectable		 3v4tA-4zk3A:
21.38
3v4tD-4zk3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 6 LEU A 241
LEU A 382
ILE A  32
THR A 378
 None
 0.89A 4do3B-4zk3A:
undetectable		 4do3B-4zk3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 9 LEU A  42
LEU A 174
ILE A 307
PHE A 115
GLY A 316
 None
 1.07A 4kukA-4zk3A:
undetectable		 4kukA-4zk3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 6 LEU A 325
MET A 317
LEU A 174
ILE A 168
 None
 1.09A 4okxA-4zk3A:
undetectable		 4okxA-4zk3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 12 ILE A  32
THR A  35
ALA A   7
LEU A  88
PHE A  59
 None
 1.20A 4pbhA-4zk3A:
undetectable		 4pbhA-4zk3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zk3 SERPIN B3
(Homo
sapiens) 		4 / 6 ILE A 307
LEU A 325
PHE A 308
THR A  35
 None
 0.93A 5b1aN-4zk3A:
undetectable
5b1aW-4zk3A:
undetectable		 5b1aN-4zk3A:
20.65
5b1aW-4zk3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 9 ILE A  34
VAL A 151
LEU A 162
ILE A 159
LEU A 299
 None
 1.37A 5iepA-4zk3A:
undetectable		 5iepA-4zk3A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 7 PHE A  19
ILE A  27
PHE A 287
ILE A  34
ALA A 343
 None
 1.49A 6b5vA-4zk3A:
undetectable
6b5vC-4zk3A:
undetectable		 6b5vA-4zk3A:
12.74
6b5vC-4zk3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4zk3 SERPIN B3
(Homo
sapiens) 		5 / 7 PHE A  19
ILE A  27
PHE A 287
ILE A  34
ALA A 343
 None
 1.49A 6b5vC-4zk3A:
undetectable
6b5vD-4zk3A:
undetectable		 6b5vC-4zk3A:
12.74
6b5vD-4zk3A:
12.74