SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 VAL A  58
GLY A  57
GLY A 258
HIS A 173
GLU A 198
 None
None
None
NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
 1.24A 1iolA-4zk6A:
undetectable		 1iolA-4zk6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.44A 1j36A-4zk6A:
undetectable		 1j36A-4zk6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.44A 1j36B-4zk6A:
undetectable		 1j36B-4zk6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.39A 1o86A-4zk6A:
undetectable		 1o86A-4zk6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 GLU A 198
HIS A 173
HIS A 196
 NTM  A 402 (-3.2A)
NTM  A 402 (-4.6A)
NTM  A 402 ( 3.7A)
 0.70A 1oe2A-4zk6A:
undetectable		 1oe2A-4zk6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.46A 2c6nB-4zk6A:
undetectable		 2c6nB-4zk6A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_ACTB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		4 / 4 HIS A 188
PRO A 189
ASN A 190
TYR A 248
 None
 0.82A 2f7aB-4zk6A:
undetectable		 2f7aB-4zk6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		4 / 6 LEU A 149
GLN A 204
ILE A 200
PRO A 201
 None
 1.03A 2fcnA-4zk6A:
undetectable
2fcnB-4zk6A:
undetectable		 2fcnA-4zk6A:
15.12
2fcnB-4zk6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 HIS A  21
MET A  61
MET A 259
 NTM  A 402 ( 3.9A)
NTM  A 402 (-3.5A)
None
 1.28A 2vj1A-4zk6A:
undetectable		 2vj1A-4zk6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.37A 2x8zA-4zk6A:
undetectable		 2x8zA-4zk6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 HIS A 173
GLU A 198
HIS A 196
HIS A  21
TYR A  23
 NTM  A 402 (-4.6A)
NTM  A 402 (-3.2A)
NTM  A 402 ( 3.7A)
NTM  A 402 ( 3.9A)
SF4  A 401 (-4.8A)
 1.37A 2x91A-4zk6A:
undetectable		 2x91A-4zk6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 THR A 263
SER A  78
LYS A 275
 None
 1.21A 3aocC-4zk6A:
undetectable		 3aocC-4zk6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		3 / 3 VAL A 203
LYS A 206
HIS A 188
 None
 0.83A 3elzA-4zk6A:
undetectable		 3elzA-4zk6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.09A 3olsA-4zk6A:
undetectable		 3olsA-4zk6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		4 / 6 ALA A 116
ILE A  94
LEU A 108
ALA A 288
 None
 0.86A 3r9sC-4zk6A:
undetectable		 3r9sC-4zk6A:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.13A 4pxmA-4zk6A:
undetectable		 4pxmA-4zk6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.14A 4pxmB-4zk6A:
undetectable		 4pxmB-4zk6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 GLY A  57
TYR A  23
SER A  38
ALA A  62
GLU A  63
 None
SF4  A 401 (-4.8A)
NTM  A 402 ( 2.5A)
None
None
 1.28A 4ymgA-4zk6A:
undetectable		 4ymgA-4zk6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 10 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.13A 5dx3A-4zk6A:
undetectable		 5dx3A-4zk6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 11 MET A  61
LEU A  68
ALA A  45
GLY A  36
HIS A  21
 NTM  A 402 (-3.5A)
None
None
None
NTM  A 402 ( 3.9A)
 1.14A 5dxgB-4zk6A:
undetectable		 5dxgB-4zk6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		4 / 5 TYR A 276
LYS A 275
GLU A 269
SER A  78
 None
 1.41A 5jhdJ-4zk6A:
undetectable		 5jhdJ-4zk6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 VAL A 164
ILE A 292
ALA A 291
MET A 295
VAL A 110
 None
 1.10A 5n0sA-4zk6A:
2.5		 5n0sA-4zk6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 VAL A 164
ILE A 292
ALA A 291
MET A 295
VAL A 110
 None
 1.08A 5n0wB-4zk6A:
2.9		 5n0wB-4zk6A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		5 / 12 VAL A 164
ILE A 292
ALA A 291
MET A 295
VAL A 110
 None
 1.08A 5n4iA-4zk6A:
1.9		 5n4iA-4zk6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4zk6 QUINOLINATE SYNTHASE
A
(Pyrococcus
horikoshii) 		4 / 6 ASN A 128
VAL A 132
VAL A 107
THR A 123
 None
 1.43A 6f32B-4zk6A:
undetectable		 6f32B-4zk6A:
21.62