SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 669
ASP A 695
ASP A 666
 ASP  A 669 ( 0.5A)
ASP  A 695 ( 0.6A)
ASP  A 666 ( 0.6A)
 0.64A 1eizA-4zkeA:
3.3		 1eizA-4zkeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 669
ASP A 695
ASP A 666
 ASP  A 669 ( 0.5A)
ASP  A 695 ( 0.6A)
ASP  A 666 ( 0.6A)
 0.67A 1ej0A-4zkeA:
undetectable		 1ej0A-4zkeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 422
LEU A 273
GLY A 274
ILE A 402
 LEU  A 422 ( 0.6A)
LEU  A 273 ( 0.6A)
GLY  A 274 ( 0.0A)
ILE  A 402 ( 0.7A)
 0.86A 1mt1G-4zkeA:
undetectable
1mt1J-4zkeA:
undetectable		 1mt1G-4zkeA:
12.77
1mt1J-4zkeA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 402
LEU A 422
LEU A 273
GLY A 274
 ILE  A 402 ( 0.7A)
LEU  A 422 ( 0.6A)
LEU  A 273 ( 0.6A)
GLY  A 274 ( 0.0A)
 0.84A 1mt1H-4zkeA:
undetectable
1mt1K-4zkeA:
undetectable		 1mt1H-4zkeA:
11.55
1mt1K-4zkeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 381
ILE A 423
LEU A 425
LEU A 284
LEU A 283
 VAL  A 381 ( 0.6A)
ILE  A 423 ( 0.7A)
LEU  A 425 ( 0.6A)
LEU  A 284 ( 0.6A)
LEU  A 283 ( 0.6A)
 1.18A 2a15A-4zkeA:
undetectable		 2a15A-4zkeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 469
MET A 299
MET A 296
LEU A 302
 LEU  A 469 (-0.6A)
MET  A 299 ( 0.0A)
MET  A 296 ( 0.0A)
LEU  A 302 ( 0.6A)
 1.45A 2oz7A-4zkeA:
undetectable		 2oz7A-4zkeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 402
LEU A 422
LEU A 273
GLY A 274
 ILE  A 402 ( 0.7A)
LEU  A 422 ( 0.6A)
LEU  A 273 ( 0.6A)
GLY  A 274 ( 0.0A)
 0.80A 2qqcD-4zkeA:
undetectable
2qqcE-4zkeA:
undetectable		 2qqcD-4zkeA:
12.79
2qqcE-4zkeA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 364
LEU A 382
ILE A 442
GLY A 274
 PHE  A 364 ( 1.3A)
LEU  A 382 ( 0.6A)
ILE  A 442 ( 0.7A)
GLY  A 274 ( 0.0A)
 1.01A 2v0mC-4zkeA:
undetectable		 2v0mC-4zkeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 461
LEU A 422
TYR A 380
LEU A 273
LEU A 450
 PHE  A 461 ( 1.3A)
LEU  A 422 ( 0.6A)
TYR  A 380 ( 1.3A)
LEU  A 273 ( 0.6A)
LEU  A 450 ( 0.6A)
 1.15A 3e23A-4zkeA:
undetectable		 3e23A-4zkeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 728
HIS A 678
VAL A 719
 ASN  A 728 ( 0.6A)
HIS  A 678 ( 1.0A)
VAL  A 719 ( 0.6A)
 0.82A 3elzB-4zkeA:
undetectable		 3elzB-4zkeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 655
ASN A 727
HIS A 678
LEU A 657
 ILE  A 655 ( 0.7A)
ASN  A 727 ( 0.6A)
HIS  A 678 ( 1.0A)
LEU  A 657 ( 0.6A)
 0.97A 3oi8A-4zkeA:
undetectable		 3oi8A-4zkeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 578
ILE A 557
GLY A 529
ILE A 629
VAL A 609
 VAL  A 578 ( 0.6A)
ILE  A 557 ( 0.4A)
GLY  A 529 ( 0.0A)
ILE  A 629 ( 0.6A)
VAL  A 609 ( 0.6A)
 1.03A 3t3cB-4zkeA:
undetectable		 3t3cB-4zkeA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.85A 3u5kA-4zkeA:
undetectable		 3u5kA-4zkeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.76A 3u5kB-4zkeA:
undetectable		 3u5kB-4zkeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.86A 3u5kC-4zkeA:
undetectable		 3u5kC-4zkeA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 285
LEU A 588
ASP A 356
LEU A 284
ILE A 339
 GLY  A 285 ( 0.0A)
LEU  A 588 ( 0.6A)
ASP  A 356 ( 0.6A)
LEU  A 284 ( 0.6A)
ILE  A 339 ( 0.4A)
 1.07A 3wdmD-4zkeA:
undetectable		 3wdmD-4zkeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 257
GLN A 558
ILE A 557
TYR A 556
 ILE  A 257 ( 0.4A)
GLN  A 558 ( 0.6A)
ILE  A 557 ( 0.4A)
TYR  A 556 ( 1.3A)
 1.25A 4a99D-4zkeA:
undetectable		 4a99D-4zkeA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.78A 4a9jA-4zkeA:
undetectable		 4a9jA-4zkeA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.74A 4a9jB-4zkeA:
undetectable		 4a9jB-4zkeA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 708
LEU A 687
LEU A 674
ILE A 659
 VAL  A 708 ( 0.6A)
LEU  A 687 ( 0.6A)
LEU  A 674 ( 0.6A)
ILE  A 659 ( 0.7A)
 0.84A 4a9jC-4zkeA:
undetectable		 4a9jC-4zkeA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 11 GLN A 568
THR A 681
PHE A 715
ILE A 710
HIS A 678
 GLN  A 568 ( 0.6A)
THR  A 681 ( 0.8A)
PHE  A 715 ( 1.3A)
ILE  A 710 ( 0.7A)
HIS  A 678 ( 1.0A)
 1.03A 4bb2A-4zkeA:
undetectable
4bb2B-4zkeA:
undetectable		 4bb2A-4zkeA:
23.00
4bb2B-4zkeA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 568
THR A 681
PHE A 715
ILE A 710
HIS A 678
 GLN  A 568 ( 0.6A)
THR  A 681 ( 0.8A)
PHE  A 715 ( 1.3A)
ILE  A 710 ( 0.7A)
HIS  A 678 ( 1.0A)
 1.06A 4c49C-4zkeA:
undetectable		 4c49C-4zkeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 555
GLY A 599
LEU A 605
VAL A 550
 GLY  A 555 ( 0.0A)
GLY  A 599 ( 0.0A)
LEU  A 605 ( 0.6A)
VAL  A 550 ( 0.6A)
 0.92A 4fgzB-4zkeA:
2.2		 4fgzB-4zkeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 744
LEU A 717
LYS A 626
GLY A 627
 ILE  A 744 ( 0.7A)
LEU  A 717 ( 0.6A)
LYS  A 626 ( 0.0A)
GLY  A 627 ( 0.0A)
 1.05A 4hbfA-4zkeA:
undetectable		 4hbfA-4zkeA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.10A 4n09A-4zkeA:
undetectable		 4n09A-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.09A 4n09B-4zkeA:
4.1		 4n09B-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 687
SER A 697
LEU A 704
LEU A 674
 LEU  A 687 ( 0.6A)
SER  A 697 ( 0.0A)
LEU  A 704 ( 0.6A)
LEU  A 674 ( 0.6A)
 1.10A 4n09D-4zkeA:
3.7		 4n09D-4zkeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 676
ASN A 683
LEU A 373
ILE A 710
PHE A 715
 LEU  A 676 ( 0.6A)
ASN  A 683 ( 0.6A)
LEU  A 373 ( 0.6A)
ILE  A 710 ( 0.7A)
PHE  A 715 ( 1.3A)
 1.47A 4p6xI-4zkeA:
undetectable		 4p6xI-4zkeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 498
GLU A 440
ASP A 435
 TRP  A 498 ( 0.5A)
GLU  A 440 ( 0.6A)
ASP  A 435 ( 0.6A)
 1.01A 5gqbA-4zkeA:
undetectable		 5gqbA-4zkeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 THR A 282
SER A 281
GLY A 279
ASN A 315
 THR  A 282 (-0.8A)
SER  A 281 ( 0.0A)
GLY  A 279 (-0.0A)
ASN  A 315 (-0.6A)
 0.86A 5k4pA-4zkeA:
undetectable		 5k4pA-4zkeA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 376
PRO A 377
TYR A 380
ASN A 728
 ASP  A 376 ( 0.6A)
PRO  A 377 ( 1.1A)
TYR  A 380 ( 1.3A)
ASN  A 728 ( 0.6A)
 1.02A 5l1fC-4zkeA:
4.6		 5l1fC-4zkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 329
GLY A 331
SER A 316
LEU A 302
THR A 324
 GLU  A 329 ( 0.6A)
GLY  A 331 (-0.0A)
SER  A 316 ( 0.0A)
LEU  A 302 ( 0.6A)
THR  A 324 ( 0.8A)
 1.02A 5o96A-4zkeA:
2.4
5o96B-4zkeA:
undetectable		 5o96A-4zkeA:
20.56
5o96B-4zkeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 573
HIS A 566
ARG A 634
 HIS  A 573 ( 1.0A)
HIS  A 566 ( 1.0A)
ARG  A 634 ( 0.6A)
 1.11A 6b58A-4zkeA:
undetectable		 6b58A-4zkeA:
20.33