SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		5 / 12 TYR A 181
GLN A 236
VAL A 230
ILE A 229
ILE A 289
 None
 1.01A 1fkbA-4zkjA:
undetectable		 1fkbA-4zkjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		5 / 12 LEU A  15
LEU A  50
VAL A  49
VAL A   9
HIS A  12
 None
 1.31A 3m7rA-4zkjA:
undetectable		 3m7rA-4zkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		3 / 3 ILE A 265
MET A 187
ARG A 190
 None
 0.91A 4lnwA-4zkjA:
undetectable		 4lnwA-4zkjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		3 / 3 ILE A 265
MET A 187
ARG A 190
 None
 0.91A 4lnxA-4zkjA:
undetectable		 4lnxA-4zkjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		4 / 7 LEU A  58
ARG A  57
LEU A  54
LEU A  41
 None
 0.82A 4wg0L-4zkjA:
undetectable
4wg0M-4zkjA:
undetectable		 4wg0L-4zkjA:
4.33
4wg0M-4zkjA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HAU_B_ACTB502_0
(MRNA EXPORT FACTOR
ICP27 HOMOLOG)		 4zkj CRISPR-ASSOCIATED
PROTEIN CAS1
(Streptococcus
pyogenes) 		4 / 4 LEU A 177
TYR A 156
ARG A 223
ASP A 227
 None
 1.35A 6hauA-4zkjA:
0.0
6hauB-4zkjA:
0.4		 6hauA-4zkjA:
21.81
6hauB-4zkjA:
21.81