SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ALA A 115
TYR A 117
ALA A 111
TYR A 120
 None
 1.26A 2wlkA-4zkyA:
undetectable
2wlkB-4zkyA:
undetectable		 2wlkA-4zkyA:
16.72
2wlkB-4zkyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASN A  67
THR A  99
ILE A 130
THR A  20
LEU A  18
 None
 1.22A 3bexC-4zkyA:
undetectable
3bexD-4zkyA:
undetectable		 3bexC-4zkyA:
20.00
3bexD-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  99
ILE A 130
THR A  20
LEU A  18
THR A  50
 None
 1.36A 3bexC-4zkyA:
undetectable
3bexD-4zkyA:
undetectable		 3bexC-4zkyA:
20.00
3bexD-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  20
LEU A  18
ASN A  67
THR A  99
ILE A 130
 None
 1.21A 3bexE-4zkyA:
undetectable
3bexF-4zkyA:
undetectable		 3bexE-4zkyA:
20.00
3bexF-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  20
LEU A  18
THR A  50
THR A  99
ILE A 130
 None
 1.35A 3bexE-4zkyA:
undetectable
3bexF-4zkyA:
undetectable		 3bexE-4zkyA:
20.00
3bexF-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  99
ILE A 130
THR A  20
LEU A  18
THR A  50
 None
 1.40A 3bf1A-4zkyA:
undetectable
3bf1B-4zkyA:
undetectable		 3bf1A-4zkyA:
20.00
3bf1B-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  20
LEU A  18
ASN A  67
THR A  99
ILE A 130
 None
 1.25A 3bf1A-4zkyA:
undetectable
3bf1B-4zkyA:
undetectable		 3bf1A-4zkyA:
20.00
3bf1B-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  99
ILE A 130
THR A  20
LEU A  18
THR A  50
 None
 1.32A 3bf1C-4zkyA:
undetectable
3bf1D-4zkyA:
undetectable		 3bf1C-4zkyA:
20.00
3bf1D-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  20
LEU A  18
ASN A  67
THR A  99
ILE A 130
 None
 1.23A 3bf1C-4zkyA:
undetectable
3bf1D-4zkyA:
undetectable		 3bf1C-4zkyA:
20.00
3bf1D-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  20
LEU A  18
THR A  50
THR A  99
ILE A 130
 None
 1.39A 3bf1C-4zkyA:
undetectable
3bf1D-4zkyA:
undetectable		 3bf1C-4zkyA:
20.00
3bf1D-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  99
ILE A 130
THR A  20
LEU A  18
THR A  50
 None
 1.36A 3bf1E-4zkyA:
undetectable
3bf1F-4zkyA:
undetectable		 3bf1E-4zkyA:
20.00
3bf1F-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  20
LEU A  18
THR A  50
THR A  99
ILE A 130
 None
 1.34A 3bf1E-4zkyA:
undetectable
3bf1F-4zkyA:
undetectable		 3bf1E-4zkyA:
20.00
3bf1F-4zkyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A  94
TRP A 137
ALA A   9
ALA A   6
TRP A  90
 None
 1.44A 4u14A-4zkyA:
undetectable		 4u14A-4zkyA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A  94
TRP A 137
ALA A   9
ALA A   6
TRP A  90
 None
 1.47A 4u15A-4zkyA:
undetectable		 4u15A-4zkyA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4zky PYRIDOXAMINE
5-PHOSPHATE OXIDASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A  94
TRP A 137
ALA A   9
ALA A   6
TRP A  90
 None
 1.45A 5cxvA-4zkyA:
undetectable		 5cxvA-4zkyA:
14.15