SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4zlc ROQUIN-2
(Homo
sapiens) 		4 / 4 ARG A 248
ALA A 186
ALA A 291
GLU A 290
 None
 1.14A 1e7bB-4zlcA:
undetectable		 1e7bB-4zlcA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 201
GLY A 193
PRO A 194
TYR A 273
PHE A 191
 None
 1.09A 1fdsA-4zlcA:
undetectable		 1fdsA-4zlcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zlc ROQUIN-2
(Homo
sapiens) 		4 / 6 ALA A 249
LEU A 201
GLU A 279
LEU A 304
 None
 0.88A 1mt1D-4zlcA:
undetectable
1mt1E-4zlcA:
undetectable		 1mt1D-4zlcA:
21.12
1mt1E-4zlcA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
 None
 1.29A 2bxfB-4zlcA:
2.2		 2bxfB-4zlcA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 208
LEU A 201
ALA A 200
GLN A 197
LEU A 245
 None
 1.35A 2oaxD-4zlcA:
undetectable		 2oaxD-4zlcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 208
LEU A 201
ALA A 200
GLN A 197
LEU A 245
 None
 1.29A 2oaxE-4zlcA:
undetectable		 2oaxE-4zlcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 SER A 301
ASP A 307
HIS A 310
ASP A 281
TRP A 181
 None
 1.41A 4dfuB-4zlcA:
undetectable		 4dfuB-4zlcA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4zlc ROQUIN-2
(Homo
sapiens) 		5 / 12 LEU A 180
SER A 302
SER A 301
LEU A 304
MET A 314
 None
 1.12A 5mwyA-4zlcA:
undetectable		 5mwyA-4zlcA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4zlc ROQUIN-2
(Homo
sapiens) 		4 / 6 TRP A 181
GLY A 292
ALA A 183
LEU A 180
 None
 0.96A 6fosA-4zlcA:
undetectable		 6fosA-4zlcA:
19.67