SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 8 GLN A1003
ASN A 976
LEU A1017
TYR A1025
 U  C   5 ( 3.5A)
G  C   6 ( 3.5A)
None
None
 1.13A 1hk3A-4zlrA:
undetectable		 1hk3A-4zlrA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		3 / 3 ASP A 880
GLU A 944
ARG A 949
 None
 0.64A 1wopA-4zlrA:
undetectable		 1wopA-4zlrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		5 / 11 ASP A 899
GLU A 889
VAL A 887
ILE A 886
HIS A 906
 None
 1.24A 2dg3A-4zlrA:
undetectable		 2dg3A-4zlrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		3 / 3 LEU A1009
GLU A 970
ILE A 971
 None
 0.60A 3czhA-4zlrA:
undetectable		 3czhA-4zlrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 6 HIS A 977
ASN A 981
ARG A 761
ASN A 958
 SO4  A1103 (-3.9A)
None
None
None
 1.40A 3galB-4zlrA:
undetectable		 3galB-4zlrA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 8 ASP A1021
LEU A1017
CYH A1004
SER A 784
 None
None
U  C   4 ( 4.2A)
None
 1.00A 3lm8B-4zlrA:
undetectable
3lm8D-4zlrA:
undetectable		 3lm8B-4zlrA:
19.66
3lm8D-4zlrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 5 VAL A 888
PHE A 898
ILE A 885
PHE A 866
 None
 0.86A 3owxB-4zlrA:
undetectable		 3owxB-4zlrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 7 ASP A1021
ILE A 794
SER A1019
TYR A1025
 None
 0.96A 3pglA-4zlrA:
undetectable		 3pglA-4zlrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 7 ASP A1021
PHE A 770
ILE A 794
TYR A1025
 None
 1.00A 3pglA-4zlrA:
undetectable		 3pglA-4zlrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		5 / 11 ILE A 973
VAL A 963
PHE A 929
VAL A 938
ILE A 965
 None
None
None
None
SO4  A1107 (-4.9A)
 1.22A 3rf4A-4zlrA:
undetectable
3rf4C-4zlrA:
undetectable		 3rf4A-4zlrA:
17.99
3rf4C-4zlrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 8 VAL A1016
GLN A 805
ILE A 795
MET A1010
 None
 1.07A 4iilA-4zlrA:
undetectable		 4iilA-4zlrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 6 ILE A 984
HIS A 977
ILE A 961
VAL A1007
 None
SO4  A1103 (-3.9A)
U  C   4 ( 4.6A)
None
 0.92A 4zj8A-4zlrA:
undetectable		 4zj8A-4zlrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4zlr BRAIN TUMOR PROTEIN
(Drosophila
melanogaster) 		4 / 5 PHE A 866
ILE A 853
GLN A 900
ARG A 864
 None
 1.28A 5jm4A-4zlrA:
undetectable		 5jm4A-4zlrA:
21.43