SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 LEU A  95
ALA A 330
GLN A  84
SER A  81
LEU A  82
 None
 1.10A 1ya3B-4zlvA:
undetectable		 1ya3B-4zlvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 10 VAL A 232
ILE A 226
LEU A 414
GLY A 267
ALA A 343
 None
 1.12A 2xf3A-4zlvA:
1.5		 2xf3A-4zlvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 9 VAL A 232
ILE A 226
LEU A 414
GLY A 267
ALA A 343
 None
 1.12A 2xf3B-4zlvA:
undetectable		 2xf3B-4zlvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 9 VAL A 232
ILE A 226
LEU A 414
GLY A 267
ALA A 343
 None
 1.12A 2xfsB-4zlvA:
1.4		 2xfsB-4zlvA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 9 VAL A 232
ILE A 226
LEU A 414
GLY A 267
ALA A 343
 None
 1.15A 2xh9B-4zlvA:
undetectable		 2xh9B-4zlvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 SER A  83
GLU A 258
ASP A 275
 None
 0.82A 2zulA-4zlvA:
undetectable		 2zulA-4zlvA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 SER A  83
GLU A 258
ASP A 275
 None
 0.82A 3dmhA-4zlvA:
undetectable		 3dmhA-4zlvA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 LEU A 132
GLY A 285
GLY A 136
ILE A 295
LEU A 331
 None
None
PLP  A 501 (-3.1A)
None
None
 0.93A 3uj7B-4zlvA:
undetectable		 3uj7B-4zlvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 ILE A 398
MET A 408
ARG A 409
 None
 0.80A 4lnwA-4zlvA:
undetectable		 4lnwA-4zlvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 ILE A 398
MET A 408
ARG A 409
 None
 0.79A 4lnxA-4zlvA:
undetectable		 4lnxA-4zlvA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 9 TYR A 171
GLY A 136
LEU A 283
VAL A 298
MET A 133
 None
PLP  A 501 (-3.1A)
None
None
None
 1.08A 4mjrA-4zlvA:
undetectable		 4mjrA-4zlvA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		5 / 12 ALA A 212
THR A 195
LEU A 200
TRP A 172
LEU A 144
 None
 1.20A 4qynA-4zlvA:
undetectable		 4qynA-4zlvA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		4 / 7 GLU A 224
ARG A 369
GLY A 231
GLY A 228
 PLP  A 501 (-4.0A)
None
None
None
 0.87A 4rdxA-4zlvA:
undetectable		 4rdxA-4zlvA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		4 / 5 SER A 142
ALA A 143
HIS A 313
LEU A 131
 None
 1.44A 5dzkb-4zlvA:
undetectable
5dzkp-4zlvA:
undetectable		 5dzkb-4zlvA:
18.12
5dzkp-4zlvA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 MET A 133
HIS A 313
GLY A 140
 None
 0.75A 5gwzB-4zlvA:
undetectable		 5gwzB-4zlvA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		4 / 4 LEU A 334
LEU A 331
SER A 287
ALA A 327
 None
 1.01A 5uunA-4zlvA:
undetectable		 5uunA-4zlvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 ARG A 265
ARG A 351
ARG A 268
 None
SO4  A 504 (-3.9A)
None
 0.88A 5vcgA-4zlvA:
undetectable		 5vcgA-4zlvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		4 / 8 ARG A 268
THR A 266
ILE A 226
PRO A 225
 None
 1.12A 6a4iA-4zlvA:
undetectable		 6a4iA-4zlvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		4 / 6 ILE A 368
TYR A 359
LEU A 358
VAL A 377
 None
 1.21A 6f6jA-4zlvA:
undetectable		 6f6jA-4zlvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE
(Toxoplasma
gondii) 		3 / 3 ARG A 342
LEU A 346
PHE A 350
 None
 0.59A 6nknP-4zlvA:
undetectable		 6nknP-4zlvA:
17.45