SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 11 LEU A  37
ALA A 433
ALA A 435
LEU A 402
GLN A 400
 None
 1.06A 1hbpA-4zm4A:
undetectable		 1hbpA-4zm4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 LEU A 198
PRO A 195
LEU A 233
ARG A 240
 None
 1.39A 1hrkB-4zm4A:
2.4		 1hrkB-4zm4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 8 VAL A 349
LEU A 440
HIS A 396
VAL A 368
 None
 1.12A 1jtvA-4zm4A:
3.5		 1jtvA-4zm4A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 11 ASN A 193
ALA A 227
LEU A 231
THR A 252
ALA A 261
 None
 1.17A 1rv7A-4zm4A:
undetectable
1rv7B-4zm4A:
undetectable		 1rv7A-4zm4A:
18.80
1rv7B-4zm4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 7 GLY A 407
ARG A 438
ILE A  58
VAL A 408
 None
 1.03A 1rxcC-4zm4A:
undetectable		 1rxcC-4zm4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 7 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.18A 1tv8A-4zm4A:
undetectable		 1tv8A-4zm4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 7 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.21A 1tv8B-4zm4A:
undetectable		 1tv8B-4zm4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		3 / 3 ASN A 193
TRP A 192
GLN A 386
 None
 1.31A 1xoqA-4zm4A:
undetectable		 1xoqA-4zm4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 LEU A 328
SER A 421
ASP A  73
ASP A  78
 None
 1.43A 2br4B-4zm4A:
2.2		 2br4B-4zm4A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 VAL A  76
LEU A 274
ILE A 104
LEU A 107
 None
 0.97A 2byoA-4zm4A:
undetectable		 2byoA-4zm4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 8 VAL A 154
LEU A 155
TYR A 147
ASP A 248
 None
None
PLP  A 501 (-4.6A)
PLP  A 501 (-2.8A)
 0.79A 2ddwA-4zm4A:
undetectable		 2ddwA-4zm4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 8 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.16A 2fb2A-4zm4A:
undetectable		 2fb2A-4zm4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 7 THR A 338
GLU A 336
THR A 364
MET A 321
 None
 1.12A 2fb2B-4zm4A:
undetectable		 2fb2B-4zm4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 LEU A 198
PRO A 195
LEU A 233
ARG A 240
 None
 1.25A 2qd2A-4zm4A:
2.4		 2qd2A-4zm4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 9 ALA A 320
ALA A 317
PHE A 116
GLY A 310
ALA A 100
 None
 1.44A 2vh3A-4zm4A:
undetectable		 2vh3A-4zm4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 5 ARG A 137
ARG A 240
GLY A 239
GLU A 236
 None
 1.28A 3k9fA-4zm4A:
undetectable
3k9fB-4zm4A:
undetectable
3k9fC-4zm4A:
undetectable		 3k9fA-4zm4A:
22.57
3k9fB-4zm4A:
22.57
3k9fC-4zm4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		3 / 3 SER A 119
GLY A 120
THR A 121
 PLP  A 501 (-4.1A)
PLP  A 501 (-3.2A)
PLP  A 501 (-3.4A)
 0.21A 3k9wA-4zm4A:
undetectable		 3k9wA-4zm4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 GLY A 191
GLU A 144
ASP A 171
ASP A 194
 None
 1.26A 3mb5A-4zm4A:
2.7		 3mb5A-4zm4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 GLY A 289
GLY A 110
ARG A 291
ALA A 293
LEU A 130
 None
 1.24A 3uj7B-4zm4A:
2.3		 3uj7B-4zm4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 ASP A  97
LEU A 297
GLY A 310
ALA A 309
GLY A  91
 None
 0.90A 3uq6B-4zm4A:
3.4		 3uq6B-4zm4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 GLN A 400
LEU A  39
LYS A 405
ALA A 403
ILE A  57
 None
 1.20A 3ut5D-4zm4A:
undetectable		 3ut5D-4zm4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 8 PHE A 419
HIS A  67
GLY A  63
GLY A 253
 None
 0.81A 3v3nB-4zm4A:
undetectable		 3v3nB-4zm4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 6 ASP A  59
GLY A  63
LEU A  49
TYR A 409
 None
 0.67A 3w9tB-4zm4A:
undetectable		 3w9tB-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		3 / 3 ASP A  59
GLY A  63
TYR A 409
 None
 0.58A 3w9tC-4zm4A:
undetectable		 3w9tC-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 6 ASP A  59
GLY A  63
LEU A  49
TYR A 409
 None
 0.68A 3w9tE-4zm4A:
undetectable		 3w9tE-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 6 ASP A  59
GLY A  63
LEU A  49
TYR A 409
 None
 0.69A 3w9tF-4zm4A:
undetectable		 3w9tF-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		3 / 3 ASP A  59
GLY A  63
TYR A 409
 None
 0.58A 3w9tG-4zm4A:
undetectable		 3w9tG-4zm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 10 ALA A 286
VAL A 246
ALA A 131
THR A 134
ALA A 293
 None
 1.04A 4j14A-4zm4A:
undetectable		 4j14A-4zm4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 6 TYR A 265
LEU A 245
GLU A 249
ALA A 127
 None
 1.02A 4nkvC-4zm4A:
undetectable		 4nkvC-4zm4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 LEU A  60
ILE A 429
HIS A 424
VAL A 432
 None
 1.05A 4xyzA-4zm4A:
undetectable		 4xyzA-4zm4A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		4 / 4 VAL A  41
ILE A  57
ASN A  61
VAL A  35
 None
 1.32A 5ajqA-4zm4A:
undetectable		 5ajqA-4zm4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 PHE A 350
LEU A  60
ILE A 429
HIS A 396
LEU A 370
 None
 1.38A 5ycpA-4zm4A:
undetectable		 5ycpA-4zm4A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 VAL A 124
VAL A 318
SER A 275
VAL A 273
HIS A 304
 None
None
PLP  A 501 ( 4.9A)
None
None
 1.19A 6ap6A-4zm4A:
undetectable		 6ap6A-4zm4A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4zm4 AMINOTRANSFERASE
(Streptomyces
pactum) 		5 / 12 VAL A 124
VAL A 318
SER A 275
VAL A 273
HIS A 304
 None
None
PLP  A 501 ( 4.9A)
None
None
 1.18A 6ap6B-4zm4A:
undetectable		 6ap6B-4zm4A:
23.89