SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 7 VAL A 114
LEU A 105
VAL A 371
TYR A 368
LEU A 363
 None
 1.30A 1cqpA-4zm6A:
6.5
1cqpB-4zm6A:
3.6		 1cqpA-4zm6A:
12.64
1cqpB-4zm6A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 GLY A 451
ARG A 422
GLU A 507
ALA A 509
HIS A 506
 None
 1.14A 1mjqC-4zm6A:
undetectable
1mjqD-4zm6A:
undetectable		 1mjqC-4zm6A:
10.43
1mjqD-4zm6A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 GLY A 451
ARG A 422
GLU A 507
ALA A 509
HIS A 506
 None
 1.15A 1mjqI-4zm6A:
undetectable
1mjqJ-4zm6A:
undetectable		 1mjqI-4zm6A:
10.43
1mjqJ-4zm6A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 6 LEU A  16
ASP A 294
GLY A 263
ARG A 256
 None
 0.82A 1mt1G-4zm6A:
undetectable
1mt1J-4zm6A:
undetectable		 1mt1G-4zm6A:
5.34
1mt1J-4zm6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 ARG A 256
LEU A  16
ASP A 294
GLY A 263
 None
 0.80A 1mt1H-4zm6A:
undetectable
1mt1K-4zm6A:
undetectable		 1mt1H-4zm6A:
9.20
1mt1K-4zm6A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 6 ARG A 256
LEU A  16
ASP A 294
GLY A 263
 None
 0.81A 1n13H-4zm6A:
undetectable
1n13K-4zm6A:
undetectable		 1n13H-4zm6A:
9.20
1n13K-4zm6A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 LEU A  16
ASP A 294
GLY A 263
ARG A 256
 None
 0.83A 1n13G-4zm6A:
undetectable
1n13J-4zm6A:
undetectable		 1n13G-4zm6A:
5.34
1n13J-4zm6A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ASN A 573
GLY A 575
MET A 614
LEU A 615
MET A 617
 None
None
None
ACO  A 901 (-4.6A)
None
 1.29A 1nhzA-4zm6A:
undetectable		 1nhzA-4zm6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 ASP A 190
GLU A  82
TYR A 501
 None
 0.70A 1wsvA-4zm6A:
undetectable		 1wsvA-4zm6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 LEU A 163
LEU A 217
PRO A 212
LEU A 135
ILE A 178
 None
 1.10A 1yi4A-4zm6A:
undetectable		 1yi4A-4zm6A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 ARG A 160
GLU A 167
LYS A 215
ALA A 216
 None
 1.24A 2ejgA-4zm6A:
undetectable		 2ejgA-4zm6A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ALA A 111
ALA A 101
ALA A 115
PRO A 133
GLY A 162
 None
 1.12A 2igtA-4zm6A:
undetectable		 2igtA-4zm6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ALA A 111
ALA A 101
ALA A 115
PRO A 133
GLY A 162
 None
 1.11A 2igtB-4zm6A:
2.5		 2igtB-4zm6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 5 VAL A 774
THR A 771
VAL A 828
GLY A 827
 None
 1.03A 2p2fA-4zm6A:
undetectable		 2p2fA-4zm6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 4 VAL A 774
THR A 771
VAL A 828
GLY A 827
 None
 1.06A 2p2fB-4zm6A:
undetectable		 2p2fB-4zm6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 MET A 127
ILE A  49
GLY A  20
MET A  18
 None
 0.91A 2pnjB-4zm6A:
2.7		 2pnjB-4zm6A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 LEU A 341
ASN A 342
GLN A 339
VAL A 174
LEU A 123
 None
 1.33A 2q7kA-4zm6A:
undetectable		 2q7kA-4zm6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 6 MET A 617
ILE A 572
PRO A 661
SER A 667
 None
None
None
ACO  A 901 (-3.8A)
 1.30A 2qd3B-4zm6A:
4.7		 2qd3B-4zm6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 ARG A 256
LEU A  16
ASP A 294
GLY A 263
 None
 0.85A 2qqcD-4zm6A:
undetectable
2qqcE-4zm6A:
undetectable		 2qqcD-4zm6A:
7.43
2qqcE-4zm6A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 8 ARG A 256
LEU A  16
ASP A 294
GLY A 263
 None
 0.75A 2qqdB-4zm6A:
undetectable
2qqdC-4zm6A:
undetectable		 2qqdB-4zm6A:
9.33
2qqdC-4zm6A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 7 PHE A 790
GLY A 691
ASP A 688
TYR A 847
 None
 1.10A 3aruA-4zm6A:
2.2		 3aruA-4zm6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 8 LEU A 367
SER A 364
THR A  94
ALA A 117
 None
 1.03A 3ax9B-4zm6A:
undetectable		 3ax9B-4zm6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 LEU A 419
ALA A 509
PRO A 372
THR A 498
VAL A 480
 None
 1.26A 3cwkA-4zm6A:
undetectable		 3cwkA-4zm6A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 SER A 191
GLY A 185
GLY A 183
ASN A 143
VAL A 145
 None
 1.39A 3f8wB-4zm6A:
undetectable		 3f8wB-4zm6A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 MET A 233
MET A 287
PHE A 181
 None
 1.34A 3gn8A-4zm6A:
undetectable		 3gn8A-4zm6A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 11 ILE A 250
SER A 244
VAL A 228
VAL A 230
GLY A 231
 None
 0.89A 3kw4A-4zm6A:
undetectable		 3kw4A-4zm6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 8 ARG A 520
LEU A 631
ASP A 633
SER A 107
 ACO  A 901 (-3.5A)
None
None
None
 1.00A 3qj7A-4zm6A:
undetectable
3qj7D-4zm6A:
undetectable		 3qj7A-4zm6A:
14.67
3qj7D-4zm6A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ALA A 115
LEU A 122
ASN A 130
PRO A 133
LEU A 135
 None
 1.20A 3tm4B-4zm6A:
undetectable		 3tm4B-4zm6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 GLY A 168
ALA A 216
ASN A 130
PRO A 133
LEU A 135
 None
 1.18A 3tm4B-4zm6A:
undetectable		 3tm4B-4zm6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 4 LYS A 215
ALA A 164
GLU A 637
LEU A 163
 None
 1.45A 3vfjA-4zm6A:
undetectable		 3vfjA-4zm6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ILE A 525
GLY A 152
ILE A 146
TYR A 484
ASN A 454
 None
 1.15A 4a81A-4zm6A:
undetectable		 4a81A-4zm6A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 LEU A  16
GLY A  14
ASN A  38
MET A 295
ALA A 296
 None
 1.31A 4eb4A-4zm6A:
undetectable		 4eb4A-4zm6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 ARG A 755
GLU A 720
ASN A 760
 None
 0.92A 4imaD-4zm6A:
11.7		 4imaD-4zm6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 ARG A 755
GLU A 720
ASN A 760
 None
 0.91A 4ip7D-4zm6A:
7.6		 4ip7D-4zm6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 8 SER A 766
PHE A 732
TRP A 735
TYR A 739
 None
 1.10A 4j7uD-4zm6A:
5.3		 4j7uD-4zm6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 LYS A 717
PRO A 718
SER A 719
 None
 0.45A 4k50I-4zm6A:
undetectable		 4k50I-4zm6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 ILE A 764
MET A 706
ARG A 705
 None
 0.82A 4lnwA-4zm6A:
undetectable		 4lnwA-4zm6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 ILE A 764
MET A 706
ARG A 705
 None
 0.84A 4lnxA-4zm6A:
undetectable		 4lnxA-4zm6A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 6 ARG A  47
GLU A 271
VAL A 275
ALA A 274
 None
 0.84A 4nkxA-4zm6A:
undetectable		 4nkxA-4zm6A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 11 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.04A 4qvlK-4zm6A:
undetectable
4qvlL-4zm6A:
undetectable		 4qvlK-4zm6A:
13.68
4qvlL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 11 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.04A 4qvlY-4zm6A:
undetectable
4qvlZ-4zm6A:
undetectable		 4qvlY-4zm6A:
13.68
4qvlZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 9 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 4qvmK-4zm6A:
undetectable
4qvmL-4zm6A:
undetectable		 4qvmK-4zm6A:
13.68
4qvmL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 4qvmY-4zm6A:
undetectable
4qvmZ-4zm6A:
undetectable		 4qvmY-4zm6A:
13.68
4qvmZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 9 ALA A 505
ALA A 508
VAL A 148
GLY A  84
ALA A 101
 None
 1.23A 4qvnK-4zm6A:
undetectable
4qvnL-4zm6A:
undetectable		 4qvnK-4zm6A:
13.68
4qvnL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 9 ALA A 505
ALA A 508
VAL A 148
GLY A  84
ALA A 101
 None
 1.24A 4qvnY-4zm6A:
undetectable
4qvnZ-4zm6A:
undetectable		 4qvnY-4zm6A:
13.68
4qvnZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.04A 4qvpK-4zm6A:
undetectable
4qvpL-4zm6A:
undetectable		 4qvpK-4zm6A:
13.80
4qvpL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.04A 4qvpY-4zm6A:
undetectable
4qvpZ-4zm6A:
undetectable		 4qvpY-4zm6A:
13.80
4qvpZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.05A 4qw1Y-4zm6A:
undetectable
4qw1Z-4zm6A:
undetectable		 4qw1Y-4zm6A:
13.92
4qw1Z-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 4qw3K-4zm6A:
undetectable
4qw3L-4zm6A:
undetectable		 4qw3K-4zm6A:
13.68
4qw3L-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 10 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 4qw3Y-4zm6A:
undetectable
4qw3Z-4zm6A:
undetectable		 4qw3Y-4zm6A:
13.68
4qw3Z-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 VAL A 476
LEU A 395
PHE A 394
LEU A 426
PHE A 514
 None
 1.11A 4rtbA-4zm6A:
10.1		 4rtbA-4zm6A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 11 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 5bxnK-4zm6A:
undetectable
5bxnL-4zm6A:
undetectable		 5bxnK-4zm6A:
13.68
5bxnL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 11 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 5bxnY-4zm6A:
undetectable
5bxnZ-4zm6A:
undetectable		 5bxnY-4zm6A:
13.68
5bxnZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 9 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 5d0xK-4zm6A:
undetectable
5d0xL-4zm6A:
undetectable		 5d0xK-4zm6A:
13.68
5d0xL-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 9 ALA A 505
ALA A 508
GLY A  84
GLY A  98
ALA A 101
 None
 1.03A 5d0xY-4zm6A:
undetectable
5d0xZ-4zm6A:
undetectable		 5d0xY-4zm6A:
13.68
5d0xZ-4zm6A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 4 LEU A  33
ILE A  34
GLY A  29
ILE A  65
 None
 0.90A 5dzk3-4zm6A:
undetectable
5dzkm-4zm6A:
undetectable		 5dzk3-4zm6A:
11.76
5dzkm-4zm6A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 5 ILE A  34
GLY A  29
ILE A  65
LEU A  33
 None
 0.89A 5dzki-4zm6A:
undetectable
5dzkj-4zm6A:
undetectable
5dzkx-4zm6A:
undetectable		 5dzki-4zm6A:
13.18
5dzkj-4zm6A:
13.18
5dzkx-4zm6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 ASP A  80
LYS A 179
HIS A 180
MET A 229
MET A 297
 None
 0.39A 5m6gA-4zm6A:
33.7		 5m6gA-4zm6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 5 ALA A 478
VAL A 476
PHE A 415
ILE A 384
 None
 0.76A 5of1A-4zm6A:
undetectable		 5of1A-4zm6A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		4 / 5 ALA A 478
VAL A 476
PHE A 415
ILE A 384
 None
 0.75A 5of1B-4zm6A:
undetectable		 5of1B-4zm6A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 LYS A 585
VAL A 541
ASP A 543
 None
 0.22A 6fgdA-4zm6A:
5.1		 6fgdA-4zm6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		3 / 3 HIS A 180
ARG A 149
ILE A 146
 None
 0.87A 6fgdA-4zm6A:
5.2		 6fgdA-4zm6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 GLU A 209
GLY A 185
HIS A 184
PRO A 144
GLY A 147
 None
 1.42A 6gngA-4zm6A:
5.0		 6gngA-4zm6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE
(Rhizomucor
miehei) 		5 / 12 LEU A  16
GLY A  14
ASN A  38
MET A 295
ALA A 296
 None
 1.25A 6r2eH-4zm6A:
undetectable		 6r2eH-4zm6A:
16.99