SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zmm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 323
LEU A 276
ILE A 283
ARG A 282
LEU A 250
 None
None
None
C2E  A 500 ( 3.0A)
C2E  A 500 (-4.4A)
 1.16A 1dreA-4zmmA:
undetectable		 1dreA-4zmmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 250
VAL A 268
ILE A 215
GLU A 275
PHE A 195
 C2E  A 500 (-4.4A)
C2E  A 500 (-4.1A)
None
C2E  A 500 (-3.7A)
None
 1.41A 1gx9A-4zmmA:
undetectable		 1gx9A-4zmmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.20A 1hvyC-4zmmA:
undetectable		 1hvyC-4zmmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 331
LEU A 327
ALA A 330
SER A 340
 None
 1.21A 4d7bB-4zmmA:
undetectable		 4d7bB-4zmmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 262
ASN A 227
ASP A 236
ASP A 184
GLY A 260
 None
 1.15A 4djeA-4zmmA:
undetectable		 4djeA-4zmmA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 323
LEU A 276
ILE A 283
ARG A 282
LEU A 250
 None
None
None
C2E  A 500 ( 3.0A)
C2E  A 500 (-4.4A)
 1.15A 4qlgA-4zmmA:
undetectable		 4qlgA-4zmmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 323
LEU A 276
ILE A 283
ARG A 282
LEU A 250
 None
None
None
C2E  A 500 ( 3.0A)
C2E  A 500 (-4.4A)
 1.14A 4x5fB-4zmmA:
undetectable		 4x5fB-4zmmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 323
LEU A 276
ILE A 283
ARG A 282
LEU A 250
 None
None
None
C2E  A 500 ( 3.0A)
C2E  A 500 (-4.4A)
 1.15A 4x5gA-4zmmA:
undetectable		 4x5gA-4zmmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 323
LEU A 276
ILE A 283
ARG A 282
LEU A 250
 None
None
None
C2E  A 500 ( 3.0A)
C2E  A 500 (-4.4A)
 1.16A 5hi6A-4zmmA:
undetectable		 5hi6A-4zmmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 9 ILE A 303
ILE A 216
ILE A 215
LEU A 320
 None
 0.83A 5vkqB-4zmmA:
undetectable
5vkqC-4zmmA:
undetectable		 5vkqB-4zmmA:
8.52
5vkqC-4zmmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 243
ASP A 221
ILE A 220
ILE A 226
 None
 0.97A 6fbnA-4zmmA:
undetectable		 6fbnA-4zmmA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.35A 6r2eC-4zmmA:
undetectable		 6r2eC-4zmmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.37A 6r2eD-4zmmA:
undetectable		 6r2eD-4zmmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4zmm DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.35A 6r2eG-4zmmA:
undetectable		 6r2eG-4zmmA:
20.49