SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		4 / 5 LYS A   2
LEU A  30
GLU A  27
LEU A   4
 None
 1.20A 1eta1-4zmsA:
undetectable		 1eta1-4zmsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 LEU A  65
LEU A  62
GLY A  61
VAL A 101
ALA A  50
 None
 1.08A 2oz7A-4zmsA:
undetectable		 2oz7A-4zmsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 10 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.22A 5y7pB-4zmsA:
undetectable		 5y7pB-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 10 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.24A 5y7pD-4zmsA:
undetectable		 5y7pD-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 10 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.25A 5y7pG-4zmsA:
undetectable		 5y7pG-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4zms RESPONSE REGULATOR
(Streptococcus
pneumoniae) 		5 / 10 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.24A 5y7pH-4zmsA:
undetectable		 5y7pH-4zmsA:
22.91