SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  34
ARG A  39
PHE A  42
GLY A  43
 None
 0.94A 1fapB-4zmuA:
undetectable		 1fapB-4zmuA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A  20
LEU A  17
GLU A  10
ARG A  72
GLY A 123
 None
 1.15A 1g50B-4zmuA:
undetectable		 1g50B-4zmuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.18A 1hvyC-4zmuA:
undetectable		 1hvyC-4zmuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 341
THR A 273
LEU A 276
VAL A 338
 None
 0.89A 1jgsA-4zmuA:
undetectable		 1jgsA-4zmuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 236
LEU A 189
GLY A 235
ASN A 227
THR A 187
 None
 1.07A 1likA-4zmuA:
undetectable		 1likA-4zmuA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 148
ALA A 125
ILE A  81
ALA A 154
ILE A  49
 None
 0.98A 2h42B-4zmuA:
undetectable		 2h42B-4zmuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 9 ILE A 226
ALA A 242
VAL A 238
CYH A 294
 None
 1.05A 2vufB-4zmuA:
undetectable		 2vufB-4zmuA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 122
SER A 121
ALA A 120
ASP A  19
 None
 1.17A 3aruA-4zmuA:
undetectable		 3aruA-4zmuA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 246
LEU A 256
ALA A 305
ALA A 266
VAL A 268
 None
 1.20A 3b0wA-4zmuA:
undetectable		 3b0wA-4zmuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		6 / 12 GLU A 155
ALA A 120
GLY A 123
ASP A  19
MET A  20
GLY A 127
 None
 1.50A 3g2oB-4zmuA:
undetectable		 3g2oB-4zmuA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 147
VAL A  44
GLY A  43
ILE A  63
LEU A 129
ILE A  49
 None
 1.35A 3ijdA-4zmuA:
undetectable		 3ijdA-4zmuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 147
VAL A  44
GLY A  43
ILE A  63
LEU A 129
ILE A  49
 None
 1.38A 3ijdB-4zmuA:
undetectable		 3ijdB-4zmuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A  20
LEU A  17
GLU A  10
ARG A  72
GLY A 123
 None
 1.11A 3olsA-4zmuA:
undetectable		 3olsA-4zmuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 MET A  20
LEU A  17
GLU A  10
ARG A  72
GLY A 123
 None
 1.19A 3uudA-4zmuA:
undetectable		 3uudA-4zmuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  53
SER A  75
ASP A  55
LEU A   6
GLY A  78
 None
 1.03A 4pevC-4zmuA:
undetectable		 4pevC-4zmuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 235
ILE A 226
GLY A 261
PHE A 264
ILE A 220
 None
 1.19A 4qoiA-4zmuA:
undetectable
4qoiB-4zmuA:
undetectable		 4qoiA-4zmuA:
20.86
4qoiB-4zmuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 264
LEU A 256
ALA A 249
MET A 287
 None
 1.00A 4rjdB-4zmuA:
undetectable		 4rjdB-4zmuA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 212
GLY A 311
ALA A 310
GLY A 313
 None
 0.97A 4u9uB-4zmuA:
undetectable		 4u9uB-4zmuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 187
HIS A 199
LEU A 255
 None
 0.78A 5axdA-4zmuA:
undetectable		 5axdA-4zmuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 248
PHE A 264
LEU A 256
ILE A 303
 None
 0.72A 5nujA-4zmuA:
undetectable		 5nujA-4zmuA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 258
GLY A 261
GLU A 262
 None
 0.45A 6fgdA-4zmuA:
undetectable		 6fgdA-4zmuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.41A 6r2eB-4zmuA:
undetectable		 6r2eB-4zmuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.37A 6r2eC-4zmuA:
undetectable		 6r2eC-4zmuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4zmu DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 264
ILE A 303
ASN A 336
LEU A 327
GLY A 306
 None
 1.39A 6r2eD-4zmuA:
undetectable		 6r2eD-4zmuA:
21.65