SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		5 / 12 GLY A  20
ALA A  19
GLY A  13
GLY A  12
ILE A 107
 None
 0.81A 2avvA-4zn0A:
undetectable		 2avvA-4zn0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		5 / 12 GLY A  20
ALA A  19
GLY A  13
GLY A  12
ILE A 107
 None
 0.85A 3cyxB-4zn0A:
undetectable		 3cyxB-4zn0A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		4 / 6 ALA A 300
ILE A 107
LEU A   7
GLU A 266
 None
 0.88A 3r9sC-4zn0A:
undetectable		 3r9sC-4zn0A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		5 / 12 ILE A 218
THR A 233
ASP A 158
VAL A 188
LEU A 178
 None
 1.14A 3v8vA-4zn0A:
3.7		 3v8vA-4zn0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		4 / 7 PHE A 141
ASP A 137
PHE A 140
GLY A 129
 None
 1.11A 3vnsA-4zn0A:
2.3		 3vnsA-4zn0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		5 / 11 GLY A 276
GLY A 111
ILE A 108
ASP A 277
PRO A  14
 None
 1.08A 4dcmA-4zn0A:
3.6		 4dcmA-4zn0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		4 / 7 ASN A 153
ALA A 181
VAL A 188
ARG A 187
 None
 1.16A 4ijiH-4zn0A:
undetectable		 4ijiH-4zn0A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		5 / 9 VAL A 183
LEU A 160
ARG A 187
THR A 191
ILE A 194
 None
 1.32A 4ubsA-4zn0A:
undetectable		 4ubsA-4zn0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4zn0 THIOREDOXIN
REDUCTASE
(Methanosarcina
mazei) 		4 / 7 LYS A  92
GLY A 271
ASP A 262
MET A 265
 None
 1.43A 6ag0C-4zn0A:
undetectable		 6ag0C-4zn0A:
16.81