SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Methanocaldococc
us
jannaschii;
Methanocaldococc
us
jannaschii) 		5 / 12 LEU B  30
LEU B  55
ILE A  15
THR A   7
ILE B  41
 None
 1.13A 1tw4A-4zn1B:
undetectable		 1tw4A-4zn1B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		5 / 10 GLN A  11
MET A  60
ILE A  57
VAL A   5
VAL A  43
 None
 1.19A 3fhjE-4zn1A:
undetectable		 3fhjE-4zn1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A  63
ALA A   4
VAL A  45
ILE A  66
ILE A  15
 None
 1.15A 3retA-4zn1A:
undetectable
3retB-4zn1A:
undetectable		 3retA-4zn1A:
20.71
3retB-4zn1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  66
MET A  19
ARG A  22
 None
 0.86A 4lnwA-4zn1A:
undetectable		 4lnwA-4zn1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  66
MET A  19
ARG A  22
 None
 0.85A 4lnxA-4zn1A:
undetectable		 4lnxA-4zn1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A  47
ILE A  33
ILE A  76
ILE A  66
VAL A  53
 None
 0.93A 4nptA-4zn1A:
undetectable		 4nptA-4zn1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
TRANSCRIPTION
ELONGATION FACTOR
SPT4
(Methanocaldococc
us
jannaschii;
Methanocaldococc
us
jannaschii) 		5 / 12 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.22A 5hw4A-4zn1B:
undetectable		 5hw4A-4zn1B:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  15
VAL A  45
ILE A  66
LEU A  56
 None
 0.78A 5og9A-4zn1A:
undetectable		 5og9A-4zn1A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4zn1 TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A  33
ALA A  16
GLY A  17
LEU A  18
GLY A  10
 None
 1.23A 6nm4B-4zn1A:
undetectable		 6nm4B-4zn1A:
18.82