SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 1jffB-4zn2A:
2.4		 1jffB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 115
LEU A 150
SER A  96
LEU A  97
LEU A  80
 None
 1.04A 2ceoA-4zn2A:
undetectable		 2ceoA-4zn2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 6 TRP A 273
LEU A  78
ARG A 315
GLY A  48
 None
 1.08A 2hs2B-4zn2A:
undetectable		 2hs2B-4zn2A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 207
GLY A 205
GLY A 223
LEU A 222
LEU A 225
 None
 1.07A 2hw2A-4zn2A:
undetectable		 2hw2A-4zn2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 2hxfB-4zn2A:
undetectable		 2hxfB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 2hxhB-4zn2A:
undetectable		 2hxhB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 2p4nB-4zn2A:
undetectable		 2p4nB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 164
GLU A 165
HIS A 237
TYR A 239
GLU A 276
 None
 0.60A 2v3dA-4zn2A:
21.1		 2v3dA-4zn2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 2wbeB-4zn2A:
2.7		 2wbeB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  85
TYR A 114
ARG A  84
TRP A  55
 None
 1.47A 2x2iD-4zn2A:
2.0		 2x2iD-4zn2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 269
SER A 188
TYR A 181
VAL A 227
 None
 0.71A 2y05A-4zn2A:
undetectable
2y05B-4zn2A:
undetectable		 2y05A-4zn2A:
21.10
2y05B-4zn2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.20A 3dcoB-4zn2A:
2.7		 3dcoB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 3edlB-4zn2A:
undetectable		 3edlB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 305
LEU A 302
GLN A 297
LEU A  71
THR A 320
 None
 1.29A 3gwuA-4zn2A:
undetectable		 3gwuA-4zn2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.19A 3iz0B-4zn2A:
2.7		 3iz0B-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.17A 3j6pB-4zn2A:
undetectable		 3j6pB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 270
SER A 210
VAL A 227
THR A 235
 None
 1.12A 3tneA-4zn2A:
undetectable		 3tneA-4zn2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 312
ARG A  39
PHE A  46
TYR A 236
ILE A 260
 None
 1.47A 3uf8A-4zn2A:
undetectable		 3uf8A-4zn2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 295
GLY A 293
TYR A 300
GLN A 289
 None
 1.00A 3w9tD-4zn2A:
undetectable		 3w9tD-4zn2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 295
GLY A 293
TYR A 300
GLN A 289
 None
 0.94A 3w9tE-4zn2A:
undetectable		 3w9tE-4zn2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 295
GLY A 293
TYR A 300
GLN A 289
 None
 0.99A 3w9tG-4zn2A:
undetectable		 3w9tG-4zn2A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  77
HIS A 237
TYR A 114
 None
 1.30A 4fu8A-4zn2A:
undetectable		 4fu8A-4zn2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  77
HIS A 237
TYR A 114
 None
 1.30A 4fu9A-4zn2A:
undetectable		 4fu9A-4zn2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 264
PHE A 209
GLU A 211
PHE A 253
GLY A 278
 None
 1.29A 4hvcB-4zn2A:
undetectable		 4hvcB-4zn2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 138
GLU A  89
ARG A 146
GLU A  86
 None
 1.49A 4kr3A-4zn2A:
undetectable		 4kr3A-4zn2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 264
PHE A 209
GLU A 211
PHE A 253
GLY A 278
 None
 1.23A 4ydqA-4zn2A:
undetectable		 4ydqA-4zn2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  85
LEU A 150
SER A 156
PHE A 113
LEU A  80
 None
 1.17A 5hnyB-4zn2A:
2.1		 5hnyB-4zn2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 422
SER A 435
THR A 410
PRO A 414
GLY A 417
 None
 1.16A 5ogcB-4zn2A:
undetectable		 5ogcB-4zn2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4zn2 PSLG
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 261
GLY A 205
ALA A 204
VAL A 227
 None
 0.77A 6dwnB-4zn2A:
undetectable		 6dwnB-4zn2A:
12.72