SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 8 SER C 170
VAL C 194
ALA C 174
GLU C 169
 None
 1.10A 1dmiA-4zngC:
undetectable
1dmiB-4zngC:
undetectable		 1dmiA-4zngC:
22.10
1dmiB-4zngC:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 10 LEU C  44
LEU C  27
ILE C 104
PHE C  47
ILE C  97
 None
 1.31A 1i18A-4zngC:
undetectable
1i18B-4zngC:
undetectable		 1i18A-4zngC:
13.73
1i18B-4zngC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 10 PHE C  47
ILE C  97
LEU C  44
LEU C  27
ILE C 104
 None
 1.34A 1i18A-4zngC:
undetectable
1i18B-4zngC:
undetectable		 1i18A-4zngC:
13.73
1i18B-4zngC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 6 ASP C 301
THR C 125
GLU C 129
GLU C 100
 None
 1.46A 2dttB-4zngC:
undetectable
2dttC-4zngC:
undetectable		 2dttB-4zngC:
16.02
2dttC-4zngC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 12 GLY C 327
TYR C 286
GLY C 287
ILE C 338
LEU C 219
 None
 1.07A 2plwA-4zngC:
undetectable		 2plwA-4zngC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 7 LEU C 342
ASP C 340
ILE C 338
MET C 261
 None
 1.00A 2qqdA-4zngC:
undetectable
2qqdE-4zngC:
undetectable		 2qqdA-4zngC:
9.97
2qqdE-4zngC:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 5 LEU C 294
GLY C 295
PHE C 290
ARG C 278
 None
 1.17A 3smtA-4zngC:
undetectable		 3smtA-4zngC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 12 LEU C 133
ASN C 312
ALA C 270
ILE C 316
ILE C 308
 None
 1.15A 3ut5B-4zngC:
undetectable		 3ut5B-4zngC:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 7 ILE C 330
TYR C 286
PHE C 245
ASN C 243
 None
 1.16A 4o7gA-4zngC:
undetectable
4o7gB-4zngC:
undetectable		 4o7gA-4zngC:
21.47
4o7gB-4zngC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 6 ILE C 330
TYR C 286
PHE C 245
ASN C 243
 None
 1.30A 4o7gB-4zngC:
undetectable		 4o7gB-4zngC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4zng PROLIDASE
(Lactococcus
lactis) 		3 / 3 ASP C 221
ASP C 232
ASN C 324
 MN  C 401 (-2.2A)
MN  C 401 (-2.2A)
None
 0.83A 4q5mA-4zngC:
undetectable		 4q5mA-4zngC:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4zng PROLIDASE
(Lactococcus
lactis) 		4 / 7 ASP C 232
GLY C 295
GLY C 297
HIS C 303
 MN  C 401 (-2.2A)
None
None
None
 1.04A 5n9xA-4zngC:
undetectable		 5n9xA-4zngC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 9 ASN C 324
PHE C 322
GLY C 297
GLY C 295
LEU C 294
 None
 1.26A 5wm2A-4zngC:
undetectable		 5wm2A-4zngC:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 9 ASP C 232
MET C 188
GLY C 157
VAL C 173
ILE C 172
 MN  C 401 (-2.2A)
None
None
None
None
 1.45A 6giqA-4zngC:
undetectable
6giqE-4zngC:
undetectable
6giqI-4zngC:
undetectable		 6giqA-4zngC:
21.91
6giqE-4zngC:
23.14
6giqI-4zngC:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zng PROLIDASE
(Lactococcus
lactis) 		5 / 11 SER C 323
ALA C 230
PHE C 190
SER C 189
HIS C 296
 None
 1.45A 6qgbE-4zngC:
undetectable		 6qgbE-4zngC:
21.17