SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 5 ASP A 258
HIS A 305
HIS A 145
HIS A 150
 ZN  A 402 (-2.3A)
ZN  A 402 ( 3.3A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.2A)
 1.12A 1ei6A-4zo3A:
undetectable		 1ei6A-4zo3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 6 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.06A 1mt1A-4zo3A:
undetectable
1mt1F-4zo3A:
undetectable		 1mt1A-4zo3A:
9.97
1mt1F-4zo3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.02A 1n13I-4zo3A:
undetectable
1n13L-4zo3A:
undetectable		 1n13I-4zo3A:
9.97
1n13L-4zo3A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 LEU A 124
ASP A  57
TYR A 255
ILE A  97
HIS A 305
 None
None
None
None
ZN  A 402 ( 3.3A)
 1.05A 1tmxB-4zo3A:
undetectable		 1tmxB-4zo3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 HIS A 150
HIS A 145
ASN A  96
THR A  56
ILE A  95
 ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
None
None
None
 1.38A 1xlxA-4zo3A:
undetectable		 1xlxA-4zo3A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 HIS A 305
PHE A 274
ILE A  95
HIS A 145
ASP A 258
 ZN  A 402 ( 3.3A)
C6L  A 403 (-4.7A)
None
ZN  A 401 (-3.3A)
ZN  A 402 (-2.3A)
 1.39A 2pgfA-4zo3A:
undetectable		 2pgfA-4zo3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 HIS A 305
PHE A 274
ILE A  95
HIS A 150
HIS A 145
 ZN  A 402 ( 3.3A)
C6L  A 403 (-4.7A)
None
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
 1.37A 2pgfA-4zo3A:
undetectable		 2pgfA-4zo3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 ASP A 149
HIS A 150
HIS A 237
ASP A 258
HIS A 305
 ZN  A 402 ( 2.6A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
ZN  A 402 ( 3.3A)
 0.53A 2q0jB-4zo3A:
14.7		 2q0jB-4zo3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 ASP A 149
HIS A 150
HIS A 237
ASP A 258
PHE A 274
 ZN  A 402 ( 2.6A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
C6L  A 403 (-4.7A)
 1.11A 2q0jB-4zo3A:
14.7		 2q0jB-4zo3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 ILE A  91
ARG A  86
ASP A 263
LEU A 306
 None
 1.00A 2qqcB-4zo3A:
undetectable
2qqcC-4zo3A:
undetectable		 2qqcB-4zo3A:
17.95
2qqcC-4zo3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.03A 2qqcA-4zo3A:
undetectable
2qqcF-4zo3A:
undetectable		 2qqcA-4zo3A:
11.24
2qqcF-4zo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.04A 2qqcG-4zo3A:
undetectable
2qqcJ-4zo3A:
undetectable		 2qqcG-4zo3A:
11.24
2qqcJ-4zo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.01A 2qqcI-4zo3A:
undetectable
2qqcL-4zo3A:
undetectable		 2qqcI-4zo3A:
11.24
2qqcL-4zo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 5 HIS A 237
HIS A 261
HIS A 305
ASP A 149
 ZN  A 401 ( 3.2A)
C6L  A 403 (-3.8A)
ZN  A 402 ( 3.3A)
ZN  A 402 ( 2.6A)
 1.20A 3c0zA-4zo3A:
undetectable		 3c0zA-4zo3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 LEU A 216
ILE A 141
GLY A 152
ILE A 170
ILE A 168
 None
 0.85A 3ebzA-4zo3A:
undetectable		 3ebzA-4zo3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 ILE A 170
GLY A 114
LEU A 205
ILE A  60
ILE A  95
 None
None
None
C6L  A 403 ( 4.7A)
None
 1.08A 3pwwA-4zo3A:
undetectable		 3pwwA-4zo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 HIS A 175
ASP A 220
TYR A 219
LEU A 225
 None
 1.22A 3wg7A-4zo3A:
undetectable
3wg7C-4zo3A:
undetectable
3wg7P-4zo3A:
undetectable		 3wg7A-4zo3A:
19.62
3wg7C-4zo3A:
20.51
3wg7P-4zo3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 MET A  93
ASP A 149
GLU A  62
HIS A 261
 None
ZN  A 402 ( 2.6A)
None
C6L  A 403 (-3.8A)
 1.24A 4aq7A-4zo3A:
undetectable		 4aq7A-4zo3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 HIS A 145
HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.70A 4c1dB-4zo3A:
15.3		 4c1dB-4zo3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 HIS A 145
HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.72A 4c1fA-4zo3A:
3.7
4c1fB-4zo3A:
15.8		 4c1fA-4zo3A:
24.92
4c1fB-4zo3A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 9 HIS A 145
HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.69A 4c1hA-4zo3A:
15.9		 4c1hA-4zo3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 GLY A 152
ASP A 149
GLY A 112
HIS A 305
 None
ZN  A 402 ( 2.6A)
None
ZN  A 402 ( 3.3A)
 0.91A 4c5nA-4zo3A:
undetectable		 4c5nA-4zo3A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 GLY A 152
ASP A 149
GLY A 112
HIS A 145
HIS A 305
 None
ZN  A 402 ( 2.6A)
None
ZN  A 401 (-3.3A)
ZN  A 402 ( 3.3A)
 1.03A 4c5nB-4zo3A:
undetectable		 4c5nB-4zo3A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 GLY A 273
ALA A  69
ALA A 190
ASP A 279
ALA A 283
 None
 1.12A 4df3A-4zo3A:
undetectable		 4df3A-4zo3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.68A 4exsB-4zo3A:
15.3		 4exsB-4zo3A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 LEU A 124
LEU A 108
ILE A 141
ILE A 208
ILE A 212
 None
 1.00A 4odrA-4zo3A:
undetectable
4odrB-4zo3A:
undetectable		 4odrA-4zo3A:
17.35
4odrB-4zo3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 ASP A  57
PHE A 123
GLY A 122
GLY A  41
ASP A  38
 None
 1.15A 4pevB-4zo3A:
undetectable		 4pevB-4zo3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 ASP A  57
HIS A 150
HIS A 145
HIS A 147
ALA A 257
 None
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
None
 1.48A 4yhaF-4zo3A:
undetectable		 4yhaF-4zo3A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.74A 5a5zA-4zo3A:
3.4		 5a5zA-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		6 / 11 HIS A 145
HIS A 147
ASP A 149
HIS A 150
HIS A 237
ARG A 287
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
None
 1.34A 5ayaA-4zo3A:
14.9		 5ayaA-4zo3A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		6 / 11 HIS A 145
HIS A 147
ASP A 149
HIS A 150
HIS A 237
HIS A 305
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.38A 5ayaA-4zo3A:
14.9		 5ayaA-4zo3A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 GLY A  58
LEU A  55
ILE A  60
HIS A 305
THR A 121
 None
None
C6L  A 403 ( 4.7A)
ZN  A 402 ( 3.3A)
None
 1.08A 5d4uA-4zo3A:
undetectable		 5d4uA-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 GLY A  58
LEU A  55
ILE A  60
HIS A 305
THR A 121
 None
None
C6L  A 403 ( 4.7A)
ZN  A 402 ( 3.3A)
None
 1.08A 5d4uB-4zo3A:
undetectable		 5d4uB-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 TRP A 323
PHE A 321
HIS A 261
THR A 245
 None
None
C6L  A 403 (-3.8A)
None
 1.44A 5hqaA-4zo3A:
undetectable		 5hqaA-4zo3A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 6 ASP A 258
HIS A 237
HIS A 145
HIS A 305
 ZN  A 402 (-2.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 ( 3.3A)
 0.95A 5ncdA-4zo3A:
undetectable
5ncdD-4zo3A:
undetectable		 5ncdA-4zo3A:
22.11
5ncdD-4zo3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 6 ASP A 258
HIS A 237
HIS A 145
HIS A 305
 ZN  A 402 (-2.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 ( 3.3A)
 0.93A 5ncdB-4zo3A:
undetectable
5ncdC-4zo3A:
undetectable		 5ncdB-4zo3A:
22.11
5ncdC-4zo3A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 ASP A 258
HIS A 237
HIS A 145
HIS A 305
 ZN  A 402 (-2.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 ( 3.3A)
 0.85A 5nekD-4zo3A:
undetectable		 5nekD-4zo3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		6 / 10 HIS A 145
HIS A 147
HIS A 150
HIS A 237
ASP A 258
HIS A 261
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
C6L  A 403 (-3.8A)
 0.56A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 HIS A 237
HIS A 145
HIS A 261
ASP A 258
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
C6L  A 403 (-3.8A)
ZN  A 402 (-2.3A)
ZN  A 402 ( 3.3A)
 0.95A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 9 LEU A  55
ILE A  97
GLY A  58
LEU A 128
LEU A 125
 None
 1.02A 5o96A-4zo3A:
undetectable
5o96B-4zo3A:
undetectable		 5o96A-4zo3A:
22.22
5o96B-4zo3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 6 TYR A  59
ASP A  57
HIS A 305
TYR A  90
 None
None
ZN  A 402 ( 3.3A)
None
 1.30A 5ov9A-4zo3A:
undetectable		 5ov9A-4zo3A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 LEU A  55
ILE A  97
GLY A  58
LEU A 128
LEU A 125
 None
 0.98A 5twjB-4zo3A:
undetectable		 5twjB-4zo3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 TYR A 255
PHE A 302
ALA A  94
GLY A  58
 None
 0.82A 5uxdA-4zo3A:
undetectable		 5uxdA-4zo3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 HIS A 305
HIS A 145
VAL A 243
SER A 304
PRO A 235
 ZN  A 402 ( 3.3A)
ZN  A 401 (-3.3A)
None
ZN  A 402 ( 4.7A)
None
 1.49A 5z0kA-4zo3A:
undetectable
5z0kB-4zo3A:
undetectable		 5z0kA-4zo3A:
16.51
5z0kB-4zo3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 HIS A 305
HIS A 145
VAL A 243
SER A 304
PRO A 235
 ZN  A 402 ( 3.3A)
ZN  A 401 (-3.3A)
None
ZN  A 402 ( 4.7A)
None
 1.49A 5z0lA-4zo3A:
undetectable
5z0lB-4zo3A:
undetectable		 5z0lA-4zo3A:
16.51
5z0lB-4zo3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 LEU A 225
HIS A 175
ASP A 220
TYR A 219
 None
 1.24A 5z85C-4zo3A:
undetectable
5z85N-4zo3A:
undetectable
5z85P-4zo3A:
undetectable		 5z85C-4zo3A:
20.51
5z85N-4zo3A:
19.62
5z85P-4zo3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 HIS A 147
ASP A 149
HIS A 237
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 402 ( 2.6A)
ZN  A 401 ( 3.2A)
ZN  A 402 ( 3.3A)
 0.74A 5zj8A-4zo3A:
15.5		 5zj8A-4zo3A:
23.53