SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zoh'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBY_A_9CRA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	1.00A	1fbyA-4zohB: undetectable	1fbyA-4zohB: 23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBY_B_9CRB1500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	1.00A	1fbyB-4zohB: undetectable	1fbyB-4zohB: 23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	1.03A	1fm6A-4zohB: undetectable	1fm6A-4zohB: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G50_A_ESTA600_1 (ESTROGEN RECEPTOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	LEU A 171 ALA A 170 LEU A 228 ILE A 204 LEU A 191	None	1.10A	1g50A-4zohA: undetectable	1g50A-4zohA: 15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HPV_B_478B200_2 (HIV-1 PROTEASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	ALA A 366 VAL A 385 GLY A 307 ILE A 343 VAL A 570	None	1.16A	1hpvB-4zohA: undetectable	1hpvB-4zohA: 9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HXW_B_RITB301_2 (HIV-1 PROTEASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	ALA A 366 VAL A 385 GLY A 307 ILE A 343 VAL A 570	None	1.00A	1hxwB-4zohA: undetectable	1hxwB-4zohA: 9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_B_NOVB444_2 (DNA GYRASE SUBUNIT B)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ASP A 430 PHE A 538 VAL A 427	None	0.75A	1kijB-4zohA: undetectable	1kijB-4zohA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5R_A_RBFA859_1 (GLYCOGEN PHOSPHORYLASE, LIVER FORM)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	LEU A 363 GLU A 360 TYR A 359 ALA A 351 GLY A 355	None	1.45A	1l5rA-4zohA: undetectable	1l5rA-4zohA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OG5_B_SWFB502_1 (CYTOCHROME P450 2C9)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ILE A  82 LEU A  94 PHE A  55 LEU A 239 PHE A  33	None	1.19A	1og5B-4zohA: undetectable	1og5B-4zohA: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_F_BEZF511_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	4 / 5	TYR B   2 GLU A 247 PHE A  33 ALA A  35	ACY  B 305 (-4.3A) None None None	1.17A	1oniE-4zohB: undetectable 1oniF-4zohB: undetectable	1oniE-4zohB: 20.94 1oniF-4zohB: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QW6_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ARG A  38 VAL A  34 TRP A 241	None	0.83A	1qw6A-4zohA: undetectable	1qw6A-4zohA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QWC_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ARG A  38 VAL A  34 TRP A 241	None	0.89A	1qwcA-4zohA: undetectable	1qwcA-4zohA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS7_B_ACTB861_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	GLY A 307 ILE A 308 VAL A 347 SER A 410	None	1.09A	1rs7B-4zohA: undetectable	1rs7B-4zohA: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 6	ILE A 541 VAL A 542 VAL A 436 ILE A 475 ASP A 553	None	1.42A	1uwhA-4zohA: undetectable	1uwhA-4zohA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VAG_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ARG A  38 VAL A  34 TRP A 241	None	0.88A	1vagA-4zohA: 0.7	1vagA-4zohA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_E_9CRE1500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	1.02A	1xdkE-4zohB: undetectable	1xdkE-4zohB: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZVI_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ARG A  38 VAL A  34 TRP A 241	None	0.90A	1zviA-4zohA: undetectable	1zviA-4zohA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1M_A_CAMA1422_0 (CYTOCHROME P450-CAM)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	THR A 439 VAL A 494 THR A 665 ASP A 446	None None None MCN  A 801 (-2.6A)	0.88A	2a1mA-4zohA: undetectable	2a1mA-4zohA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CPP_A_CAMA422_0 (CYTOCHROME P450-CAM)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	TYR A 522 THR A 537 LEU A 460 VAL A 542	None	1.03A	2cppA-4zohA: undetectable	2cppA-4zohA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_A_SALA506_1 (SALICYLATE SYNTHETASE, IRP9)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	ILE A 475 GLY A 490 THR A 486 GLU A 421 GLY A 438	None None MCN  A 801 (-3.4A) None None	1.41A	2fn1A-4zohA: undetectable	2fn1A-4zohA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_B_SALB503_1 (SALICYLATE SYNTHETASE, IRP9)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	ILE A 475 GLY A 490 THR A 486 GLU A 421 GLY A 438	None None MCN  A 801 (-3.4A) None None	1.37A	2fn1B-4zohA: undetectable	2fn1B-4zohA: 21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HMA_A_SAMA375_0 (PROBABLE TRNA (5-METHYLAMINOMETHYL -2-THIOURIDYLATE)-ME THYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	GLY A 438 SER A 187 THR A 439 GLY A 440 GLN A 444	None None None None MCN  A 801 (-3.9A)	1.45A	2hmaA-4zohA: undetectable	2hmaA-4zohA: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IYF_B_ERYB1399_0 (OLEANDOMYCIN GLYCOSYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ASN B 213 ILE B 207 LEU B 267 TYR B 176 ALA B 125	None	1.40A	2iyfB-4zohB: undetectable	2iyfB-4zohB: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IYF_B_ERYB1399_0 (OLEANDOMYCIN GLYCOSYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	VAL B 166 ILE B 124 LEU B 113 ALA B 122 ASP B 154	None	1.28A	2iyfB-4zohB: undetectable	2iyfB-4zohB: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_A_SC2A1290_1 (FICOLIN-2)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 5	SER A 184 LEU A 165 GLY A 212 ARG A 245	None FES  C 202 ( 4.1A) None None	1.08A	2j2pA-4zohA: undetectable 2j2pB-4zohA: undetectable	2j2pA-4zohA: 16.12 2j2pB-4zohA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_C_SC2C1289_1 (FICOLIN-2)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	ARG A 245 SER A 184 LEU A 165 GLY A 212	None None FES  C 202 ( 4.1A) None	0.99A	2j2pA-4zohA: undetectable 2j2pC-4zohA: undetectable	2j2pA-4zohA: 16.12 2j2pC-4zohA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_E_SC2E1291_1 (FICOLIN-2)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	ASP A 210 LEU C 104 GLY C 107 ARG A   9	None None FES  C 202 (-4.2A) None	1.44A	2j2pD-4zohA: undetectable 2j2pE-4zohA: undetectable	2j2pD-4zohA: 16.12 2j2pE-4zohA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_F_SC2F1289_1 (FICOLIN-2)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	ARG A 245 SER A 184 LEU A 165 GLY A 212	None None FES  C 202 ( 4.1A) None	1.00A	2j2pD-4zohA: undetectable 2j2pF-4zohA: undetectable	2j2pD-4zohA: 16.12 2j2pF-4zohA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O4N_A_TPVA300_1 (PROTEASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	LEU A 279 ILE A 275 ILE A 311 GLY A 307 ILE A 340	None	0.97A	2o4nA-4zohA: undetectable	2o4nA-4zohA: 9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_B_SAMB300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 5	SER A 187 GLY A 480 ASP A 553 ASP A 477	None	1.13A	2oxtB-4zohA: undetectable	2oxtB-4zohA: 17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_D_SAMD300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	6 / 12	GLY A 440 GLY A 491 GLY A 438 HIS A 663 ASP A 446 VAL A 487	None None None None MCN  A 801 (-2.6A) MCN  A 801 (-3.8A)	1.38A	2oxtD-4zohA: undetectable	2oxtD-4zohA: 17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_B_ACTB141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	PRO A 111 ASN A 282 ARG A 159	None	0.94A	2qeuB-4zohA: undetectable	2qeuB-4zohA: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QL8_A_BEZA143_0 (PUTATIVE REDOX PROTEIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	ALA A 616 ALA A 618 PRO A 648 TYR A 588	None	0.94A	2ql8A-4zohA: 0.7 2ql8B-4zohA: 1.8	2ql8A-4zohA: 11.17 2ql8B-4zohA: 11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_A_BEZA1222_0 (PEROXIREDOXIN 6)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	PRO A 243 VAL A 242 GLU A 225 ALA A 170	None	0.83A	2v32A-4zohA: undetectable 2v32B-4zohA: undetectable	2v32A-4zohA: 16.81 2v32B-4zohA: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_B_BEZB1220_0 (PEROXIREDOXIN 6)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	PRO A 243 VAL A 242 GLU A 225 ALA A 170	None	0.87A	2v32A-4zohA: undetectable 2v32B-4zohA: undetectable	2v32A-4zohA: 16.81 2v32B-4zohA: 16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_A_BEZA1529_0 (BENZOATE-COENZYME A LIGASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	ALA A 334 TYR A 331 ALA A 162 GLY A 253 GLY A 216	None None None None MO  A 802 ( 3.9A)	0.84A	2v7bA-4zohA: undetectable	2v7bA-4zohA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_B_BEZB1529_0 (BENZOATE-COENZYME A LIGASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	ALA A 334 TYR A 331 ALA A 162 GLY A 253 GLY A 216	None None None None MO  A 802 ( 3.9A)	0.82A	2v7bB-4zohA: 2.1	2v7bB-4zohA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1160_1 (ALLERGEN ARG R 1)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	SER B  83 TYR B  69 VAL B 166 ILE B  80	PG4  B 303 ( 4.9A) None None None	1.05A	2x45C-4zohB: undetectable	2x45C-4zohB: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_H_TC9H1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	TYR A 568 MET A 304 ILE A 412 ASP A 381	None	1.22A	2xytI-4zohA: undetectable	2xytI-4zohA: 13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YOE_C_FL7C1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	GLY C 138 ASN C 139 ILE C  58 VAL C  43	None	0.79A	2yoeB-4zohC: undetectable 2yoeC-4zohC: undetectable	2yoeB-4zohC: 19.13 2yoeC-4zohC: 19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_B_SAMB402_0 (UNCHARACTERIZED PROTEIN MJ0883)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	TYR A 331 PHE A 215 GLY A 333 ASN A 297 PHE A 342	None MCN  A 801 (-3.5A) None 1PE  A 803 (-4.5A) None	1.40A	2zznB-4zohA: undetectable	2zznB-4zohA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE510_2 (PHOSPHOLIPASE A2)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	VAL A 594 GLY A 392 ARG A 362 LEU A 363	MCN  A 801 (-4.4A) None None None	1.10A	3bjwE-4zohA: undetectable	3bjwE-4zohA: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BU1_A_HSMA301_1 (LIPOCALIN)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	SER B  83 TYR B  69 VAL B 166 ILE B  80	PG4  B 303 ( 4.9A) None None None	1.07A	3bu1A-4zohB: undetectable	3bu1A-4zohB: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	VAL A 487 ARG A   9 ILE A 462 THR A 439	MCN  A 801 (-3.8A) None None None	1.23A	3cl9A-4zohA: undetectable	3cl9A-4zohA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D9L_A_ACTA501_0 (CTD-PEPTIDE RNA-BINDING PROTEIN 16)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	4 / 5	PRO B  29 ILE B  50 PRO B  47 TYR B  49	FAD  B 301 (-3.3A) None None None	0.97A	3d9lA-4zohB: undetectable 3d9lY-4zohB: undetectable	3d9lA-4zohB: 19.00 3d9lY-4zohB: 4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D9L_A_ACTA501_0 (CTD-PEPTIDE RNA-BINDING PROTEIN 16)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 5	PRO A 337 ILE A 340 PRO A 680 TYR A 341	None	1.28A	3d9lA-4zohA: undetectable 3d9lY-4zohA: undetectable	3d9lA-4zohA: 10.86 3d9lY-4zohA: 1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_A_SAMA300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.05A	3eeyA-4zohC: undetectable	3eeyA-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_B_SAMB300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.06A	3eeyB-4zohC: undetectable	3eeyB-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_C_SAMC300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.07A	3eeyC-4zohC: undetectable	3eeyC-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_D_SAMD300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.08A	3eeyD-4zohC: undetectable	3eeyD-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.06A	3eeyE-4zohC: undetectable	3eeyE-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.05A	3eeyF-4zohC: undetectable	3eeyF-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_H_SAMH300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.07A	3eeyH-4zohC: undetectable	3eeyH-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_I_SAMI300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.08A	3eeyI-4zohC: undetectable	3eeyI-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_J_SAMJ300_0 (PUTATIVE RRNA METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 12	GLY C  53 ILE C 136 GLY C 135 ASN C  51 THR A 643	FES  C 201 (-3.9A) None None FAD  B 301 ( 4.2A) None	1.07A	3eeyJ-4zohC: undetectable	3eeyJ-4zohC: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	ILE C  94 PRO C  93 PRO C 127 ASN C 126	None	0.88A	3em0B-4zohC: undetectable	3em0B-4zohC: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_B_H3PB552_1 (GLUTAMATE DEHYDROGENASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	TYR A 411 TYR A 588 ILE A 611	None	0.46A	3eteA-4zohA: undetectable 3eteB-4zohA: undetectable	3eteA-4zohA: 24.36 3eteB-4zohA: 24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FAL_C_REAC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 10	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	1.01A	3falC-4zohB: undetectable	3falC-4zohB: 25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FC6_A_REAA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	ILE B 236 ALA B 239 ALA B 240 LEU B 226 ALA B 222	None	0.95A	3fc6A-4zohB: undetectable	3fc6A-4zohB: 25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H52_B_486B1_2 (GLUCOCORTICOID RECEPTOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLY A 610 GLY A 609 VAL A 612 ARG A 256 ILE A 651	None	1.26A	3h52B-4zohA: undetectable	3h52B-4zohA: 15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HLW_A_CE3A301_2 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	CYH C  67 PRO B  38 THR C  56 ASP C  48	FES  C 201 (-2.3A) None None None	1.42A	3hlwA-4zohC: 0.0	3hlwA-4zohC: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_D_TFPD201_1 (PROTEIN S100-A4)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	GLY A  18 CYH C  52 CYH C 141 PHE A 215	None FES  C 201 (-2.1A) FES  C 202 (-2.3A) MCN  A 801 (-3.5A)	1.08A	3ko0D-4zohA: undetectable 3ko0E-4zohA: undetectable	3ko0D-4zohA: 8.96 3ko0E-4zohA: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_J_TFPJ201_1 (PROTEIN S100-A4)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	GLY A  18 CYH C  52 CYH C 141 PHE A 215	None FES  C 201 (-2.1A) FES  C 202 (-2.3A) MCN  A 801 (-3.5A)	1.08A	3ko0B-4zohA: undetectable 3ko0J-4zohA: undetectable	3ko0B-4zohA: 8.96 3ko0J-4zohA: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_C_SAMC226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ARG A 336 GLY A 216 GLY A 253 ALA A 334 GLY A 333	None MO  A 802 ( 3.9A) None None None	0.89A	3ku1C-4zohA: undetectable	3ku1C-4zohA: 17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_D_URFD254_1 (URIDINE PHOSPHORYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	GLY A 610 GLN C 105 ILE A 611 VAL A 612	None MCN  A 801 ( 3.8A) None None	1.14A	3kvvD-4zohA: undetectable	3kvvD-4zohA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_E_URFE254_1 (URIDINE PHOSPHORYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	GLY A 609 GLN C 105 ILE A 611 VAL A 612	None MCN  A 801 ( 3.8A) None None	1.17A	3kvvE-4zohA: undetectable	3kvvE-4zohA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N23_A_OBNA1_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	GLN A 562 PRO A 662 ASP A 381 ILE A 412 ARG A 485	None	1.27A	3n23A-4zohA: undetectable	3n23A-4zohA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N23_C_OBNC1_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	PRO A 662 ASP A 381 VAL A 378 THR A 566 ARG A 485	None	1.35A	3n23C-4zohA: undetectable	3n23C-4zohA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OY4_B_017B200_2 (HIV-1 PROTEASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 10	ALA A 366 VAL A 385 GLY A 307 ILE A 343 VAL A 570	None	0.98A	3oy4B-4zohA: undetectable	3oy4B-4zohA: 9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q5P_A_TACA7101_1 (MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	ASN A 157 ILE A 272 TYR A 309 GLU A 344 ILE A 340	None	1.37A	3q5pA-4zohA: undetectable	3q5pA-4zohA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SJ4_X_DXCX75_0 (CYTOCHROME C7)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	ILE C  94 LEU C 121 LYS C  65 ILE C  58 GLY C 135	None None FES  C 201 ( 4.5A) None None	1.15A	3sj4X-4zohC: undetectable	3sj4X-4zohC: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUD_B_SUEB1201_1 (NS3 PROTEASE, NS4A PROTEIN)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLN C 147 TYR A 654 GLY A 609 ALA A 607 ALA A 603	None PEG  A 804 (-4.5A) None None MCN  A 801 ( 3.9A)	1.10A	3sudB-4zohC: undetectable	3sudB-4zohC: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TM4_A_SAMA401_1 (TRNA (GUANINE N2-)-METHYLTRANSFERA SE TRM14)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	4 / 5	HIS A 222 THR A 185 GLU A 248 ASP C  48	None	1.44A	3tm4A-4zohA: undetectable	3tm4A-4zohA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UGR_A_IMNA2001_2 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 7	TYR A 102 GLU A 247 GLN A  78 TYR A  92	None None None ACY  B 305 (-4.4A)	1.22A	3ugrA-4zohA: undetectable	3ugrA-4zohA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5L_C_UEGC300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	5 / 10	GLY C 138 ALA C  54 GLY C  53 CYH C  47 CYH C  55	None None FES  C 201 (-3.9A) FES  C 201 (-2.3A) FES  C 201 (-2.2A)	1.24A	4c5lC-4zohC: undetectable	4c5lC-4zohC: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CUT_A_TYLA2971_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	VAL C  57 VAL C  43 ASN C  17 ILE C  16	None	1.21A	4cutA-4zohC: undetectable	4cutA-4zohC: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DF3_A_SAMA301_1 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	3 / 3	TYR B 259 THR A 580 GLU A 703	None	0.73A	4df3A-4zohB: undetectable	4df3A-4zohB: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAT_B_BEZB1000_0 (BENZOATE-COENZYME A LIGASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	ALA A 334 TYR A 331 ALA A 162 GLY A 253 GLY A 216	None None None None MO  A 802 ( 3.9A)	0.96A	4eatB-4zohA: undetectable	4eatB-4zohA: 24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_D_ACTD305_0 (GLUTATHIONE TRANSFERASE GTE1)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	ILE C  79 LEU C  14 LYS C  15 ASN C  60	None None None PEG  C 203 (-3.2A)	1.49A	4g19D-4zohC: undetectable	4g19D-4zohC: 24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_B_ACTB701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	HIS A 663 GLY A 418 ILE A 489	None	0.56A	4k50A-4zohA: undetectable	4k50A-4zohA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_J_ACTJ701_0 (RNA (33-MER) RNA POLYMERASE 3D-POL)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	HIS A 663 GLY A 418 ILE A 489	None	0.57A	4k50I-4zohA: undetectable	4k50I-4zohA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_D_MTXD301_1 (GAMMA-GLUTAMYL HYDROLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	GLY A 674 GLY A 610 GLY A 609 ALA A 673 GLN A 444	None None None None MCN  A 801 (-3.9A)	1.18A	4l8fD-4zohA: undetectable	4l8fD-4zohA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGH_C_SAMC401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	SER A 187 GLY A 490 LEU A 496 TRP A 482 ILE A 489	None None None 1PE  A 803 ( 4.0A) None	1.37A	4pghC-4zohA: undetectable	4pghC-4zohA: 18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PXM_B_ESTB2000_1 (ESTROGEN RECEPTOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 11	LEU A 171 ALA A 170 LEU A 228 ILE A 204 LEU A 191	None	1.06A	4pxmB-4zohA: undetectable	4pxmB-4zohA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RFQ_A_SAMA401_1 (HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	THR A 681 GLY A 569 ASP A 592 SER A 409	None	1.00A	4rfqA-4zohA: undetectable	4rfqA-4zohA: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RTS_A_SAMA301_0 (DNA ADENINE METHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLY B 208 GLY B 190 ILE B  95 ASN B  94 PRO B 120	None None FAD  B 301 (-4.1A) None None	1.25A	4rtsA-4zohB: undetectable	4rtsA-4zohB: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_D_NOVD2000_1 (DNA GYRASE SUBUNIT B)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	SER A 382 ASP A 381 ILE A 412 ILE A 308 THR A 566	None	1.28A	4uroD-4zohA: undetectable	4uroD-4zohA: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V20_A_ACTA1444_0 (CELLOBIOHYDROLASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 5	GLY A 438 THR A 439 HIS A 189 GLY A 470	None	1.04A	4v20A-4zohA: undetectable	4v20A-4zohA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	MET B 126 ILE B 164 ASP B 118 THR B  91 ILE B  80	None None FAD  B 301 (-3.7A) None None	1.37A	4xe0A-4zohB: 2.0	4xe0A-4zohB: 14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	GLY A 137 VAL A 140 PHE A 262 ILE A 275	None	1.16A	4xv2B-4zohA: undetectable	4xv2B-4zohA: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_H_TR6H101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii)	3 / 5	GLY C 138 GLY C 135 GLU C 134	None	0.47A	4z2eA-4zohC: undetectable 4z2eD-4zohC: undetectable	4z2eA-4zohC: 15.57 4z2eD-4zohC: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_DIFA602_1 (SERUM ALBUMIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 8	LEU A 552 ASN A 544 ALA A 545 GLU A 507	None	0.75A	4zbqA-4zohA: undetectable	4zbqA-4zohA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_B_SAMB301_0 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLY A 339 GLY A 335 ILE A 343 LEU A 305 ALA A 281	None	1.21A	5bw4B-4zohA: undetectable	5bw4B-4zohA: 17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C0O_H_SAMH301_1 (TRNA (ADENINE(58)-N(1))-M ETHYLTRANSFERASE TRMI)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	4 / 5	THR C  41 GLY C  39 HIS C  33 ASP A  25	None	1.12A	5c0oH-4zohC: undetectable	5c0oH-4zohC: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DV4_A_NMYA601_2 (CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	GLU A  11 TRP C  99 ASN A 599	None	0.93A	5dv4A-4zohA: undetectable	5dv4A-4zohA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DV4_A_NMYA601_2 (CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	GLU A 672 TRP A 482 ASN A 297	MCN  A 801 ( 3.2A) 1PE  A 803 ( 4.0A) 1PE  A 803 (-4.5A)	0.98A	5dv4A-4zohA: undetectable	5dv4A-4zohA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4zoh	PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLU A 248 ILE C 149 TYR C 146 GLY C 112 THR C  56	None	1.33A	5esgA-4zohA: undetectable	5esgA-4zohA: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	PHE A 181 SER A 183 ARG A 168 PHE A  36 GLY A  77	None	1.27A	5f9zB-4zohA: undetectable	5f9zB-4zohA: 23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FVO_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	3 / 3	ARG A  38 VAL A  34 TRP A 241	None	0.99A	5fvoA-4zohA: undetectable	5fvoA-4zohA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G44_A_YTZA1512_1 (NUCLEAR RECEPTOR ROR-GAMMA)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 9	LEU B  59 LEU B  74 ALA B  17 VAL B  51 ALA B  31	None None None None FAD  B 301 (-3.5A)	1.28A	5g44A-4zohB: undetectable	5g44A-4zohB: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H4D_A_BBIA403_1 (NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	GLU A 225 PHE A 181 GLU A 166 VAL A  23	None	1.39A	5h4dA-4zohA: undetectable	5h4dA-4zohA: 17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIK_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLY A 333 GLY A 216 SER A 330 GLY A 669 SER A 484	None MO  A 802 ( 3.9A) 1PE  A 803 ( 4.8A) MCN  A 801 (-3.2A) MCN  A 801 (-4.1A)	1.24A	5hikA-4zohA: undetectable	5hikA-4zohA: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_A_7V7A202_1 (ENDO-1,4-BETA-XYLANA SE A)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	PHE A 181 SER A 183 VAL A 206 TRP A 482 ALA A 188	None None None 1PE  A 803 ( 4.0A) None	1.35A	5tzoA-4zohA: undetectable	5tzoA-4zohA: 13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_C_7V7C201_1 (ENDO-1,4-BETA-XYLANA SE A)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	PHE A 181 SER A 183 VAL A 206 TRP A 482 ALA A 188	None None None 1PE  A 803 ( 4.0A) None	1.31A	5tzoC-4zohA: undetectable	5tzoC-4zohA: 13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_H_RITH602_1 (CYTOCHROME P450 3A5)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	GLY A 478 ILE A 453 PHE A 450 ALA A 449 GLY A 480	None None None MCN  A 801 (-3.1A) None	0.95A	5veuH-4zohA: undetectable	5veuH-4zohA: 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XV7_A_EMHA705_2 (SERINE-ARGININE (SR) PROTEIN KINASE 1)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 4	VAL B 264 LEU B 267 LEU B 179 ASP A 578	None	1.41A	5xv7A-4zohB: undetectable	5xv7A-4zohB: 17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CBZ_B_ESTB602_1 (ESTROGEN RECEPTOR)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 10	LEU A 171 ALA A 170 LEU A 228 ILE A 204 LEU A 191	None	1.06A	6cbzB-4zohA: undetectable	6cbzB-4zohA: 6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DK1_C_GM4C301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT PUTATIVE OXIDOREDUCTASE IRON-SULFUR SUBUNIT (Sulfurisphaera tokodaii; Sulfurisphaera tokodaii)	5 / 11	VAL C  69 TYR B   8 LEU B  30 GLU B  52 ALA C  71	None	1.33A	6dk1C-4zohC: undetectable	6dk1C-4zohC: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_B_AQ4B602_1 (CYTOCHROME P450 1A1)	4zoh	PUTATIVE OXIDOREDUCTASE FAD-BINDING SUBUNIT (Sulfurisphaera tokodaii)	5 / 7	ASN B 248 GLY B 221 ALA B 222 VAL B 191 LEU B 209	None	1.48A	6dwnB-4zohB: undetectable	6dwnB-4zohB: 14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F32_B_ACTB602_0 (AMINE OXIDASE LKCE)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	4 / 6	TYR A 588 VAL A 406 VAL A 408 THR A 681	None	1.35A	6f32B-4zohA: undetectable	6f32B-4zohA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_N_PCFN606_0 (CYTOCHROME B)	4zoh	PUTATIVE OXIDOREDUCTASE MOLYBDOPTERIN-BINDIN G SUBUNIT (Sulfurisphaera tokodaii)	5 / 12	MET A 615 ALA A 618 TYR A 341 VAL A 686 VAL A 577	None	1.39A	6hu9N-4zohA: undetectable	6hu9N-4zohA: 19.29