SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 8 PHE A 159
HIS A 129
HIS A 205
LEU A 222
 None
FE2  A 402 ( 3.6A)
FE2  A 402 (-3.6A)
None
 0.93A 1azmA-4zonA:
undetectable		 1azmA-4zonA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 8 PHE A 159
HIS A 129
HIS A 205
LEU A 222
 None
FE2  A 402 ( 3.6A)
FE2  A 402 (-3.6A)
None
 0.93A 1bzmA-4zonA:
undetectable		 1bzmA-4zonA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		5 / 12 ALA A 165
GLY A 208
GLY A 209
ILE A  32
PRO A 155
 None
 1.06A 1sqfA-4zonA:
undetectable		 1sqfA-4zonA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.91A 1wmqA-4zonA:
undetectable		 1wmqA-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.92A 1wmqB-4zonA:
undetectable		 1wmqB-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.92A 1wpuA-4zonA:
undetectable		 1wpuA-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.92A 1wpuB-4zonA:
undetectable		 1wpuB-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.93A 1wrqA-4zonA:
undetectable		 1wrqA-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 6 ARG A 117
ILE A 119
GLY A 209
ALA A 125
 None
 0.93A 1wrqB-4zonA:
undetectable		 1wrqB-4zonA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		4 / 7 VAL A  89
THR A  88
PHE A  85
ARG A  86
 None
 1.27A 2kotA-4zonA:
undetectable		 2kotA-4zonA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		5 / 9 LEU A 255
ILE A  91
PHE A 225
ALA A  79
LEU A 111
 None
 1.16A 2m9qA-4zonA:
undetectable		 2m9qA-4zonA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		5 / 11 TYR A 224
ASP A 131
PHE A 115
VAL A 221
PRO A 155
 4Q1  A 401 (-3.6A)
FE2  A 402 ( 2.8A)
4Q1  A 401 (-3.8A)
None
None
 1.31A 2vcdA-4zonA:
undetectable		 2vcdA-4zonA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		5 / 9 ALA A 101
VAL A  18
ILE A 198
LEU A  33
TYR A 109
 None
 1.38A 3fl9D-4zonA:
undetectable		 3fl9D-4zonA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 236
THR A 238
THR A  80
 None
 0.81A 5aoxB-4zonA:
undetectable		 5aoxB-4zonA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4zon VERRUCULOGEN
SYNTHASE
(Aspergillus
fumigatus) 		5 / 12 GLY A  29
GLY A 171
ARG A 174
LEU A   9
LEU A  25
 None
 1.06A 5bw4A-4zonA:
undetectable		 5bw4A-4zonA:
23.96