SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 6 LEU A 208
GLU A 201
ASP A  77
PRO A  74
 None
 0.97A 1ditH-4zowA:
undetectable
1ditP-4zowA:
undetectable		 1ditH-4zowA:
20.11
1ditP-4zowA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 SER A 118
ILE A 117
GLY A  64
GLY A  32
 None
 0.78A 1me7A-4zowA:
undetectable		 1me7A-4zowA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.95A 1rxcB-4zowA:
undetectable		 1rxcB-4zowA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.99A 1rxcE-4zowA:
undetectable		 1rxcE-4zowA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.93A 1rxcI-4zowA:
undetectable		 1rxcI-4zowA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.94A 1rxcK-4zowA:
undetectable		 1rxcK-4zowA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		3 / 3 ALA A 178
VAL A  94
TRP A  91
 None
 0.99A 1tkqA-4zowA:
undetectable		 1tkqA-4zowA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 MET A  85
GLY A 187
PHE A 185
ALA A 191
ARG A  82
 None
 1.24A 2avdB-4zowA:
undetectable		 2avdB-4zowA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 354
LEU A 233
LEU A 236
THR A 362
LEU A  62
 None
None
CLM  A 500 (-4.9A)
None
None
 0.96A 2egvA-4zowA:
undetectable		 2egvA-4zowA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 354
LEU A 233
LEU A 236
THR A 362
LEU A  62
 None
None
CLM  A 500 (-4.9A)
None
None
 0.99A 2egvB-4zowA:
undetectable		 2egvB-4zowA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 229
ALA A 237
LEU A 356
LEU A 359
LEU A 394
 None
 1.01A 2nyuA-4zowA:
undetectable		 2nyuA-4zowA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 ILE A 122
LEU A  22
ILE A 142
MET A 146
VAL A 335
 None
 0.97A 2ygqA-4zowA:
undetectable		 2ygqA-4zowA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 378
GLY A 376
ALA A 302
ALA A 303
LEU A 382
 None
 1.07A 3p2kA-4zowA:
undetectable		 3p2kA-4zowA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.99A 4e1vA-4zowA:
undetectable		 4e1vA-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.96A 4e1vC-4zowA:
undetectable		 4e1vC-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.98A 4e1vD-4zowA:
undetectable		 4e1vD-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.95A 4e1vE-4zowA:
undetectable		 4e1vE-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 0.97A 4e1vG-4zowA:
undetectable		 4e1vG-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 8 THR A 109
GLN A  37
ILE A 105
VAL A  44
 None
 1.01A 4e1vH-4zowA:
undetectable		 4e1vH-4zowA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 5 TYR A  61
GLN A 115
GLY A 116
SER A 118
 None
 1.18A 4fu8A-4zowA:
undetectable		 4fu8A-4zowA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 SER A 368
PRO A 234
MET A 316
GLY A 319
LEU A 320
 None
 0.64A 4j7xB-4zowA:
undetectable		 4j7xB-4zowA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		3 / 3 LEU A 208
ASP A 211
TYR A 212
 None
 0.53A 4qc6B-4zowA:
undetectable		 4qc6B-4zowA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		8 / 10 TYR A  30
ASN A  33
ASP A  34
LEU A  62
PRO A 154
GLY A 354
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
None
CLM  A 500 ( 4.4A)
None
None
None
 0.61A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		9 / 10 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
PRO A 154
LEU A 236
GLY A 354
GLN A 357
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.30A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 LEU A 394
PHE A 361
PHE A 221
ALA A 341
GLY A 354
 None
 1.08A 5veuB-4zowA:
undetectable		 5veuB-4zowA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		4 / 5 PHE A 230
PHE A 361
LEU A 233
LEU A 334
 None
 1.35A 5veuH-4zowA:
undetectable		 5veuH-4zowA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		11 / 11 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
GLN A  69
GLY A 123
PRO A 154
LEU A 236
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
None
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.56A 6euqA-4zowA:
67.8		 6euqA-4zowA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A  64
GLY A 116
LEU A 119
GLY A 364
ASN A  33
 None
None
CLM  A 500 ( 4.7A)
None
CLM  A 500 (-3.5A)
 0.99A 6gngB-4zowA:
undetectable		 6gngB-4zowA:
20.80