SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A  64
LEU A 124
LEU A 401
GLY A  72
 None
 1.00A 1a4lB-4zoxA:
undetectable		 1a4lB-4zoxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 105
VAL A 112
GLY A  83
TRP A 145
LEU A  91
 None
 1.27A 1fkoA-4zoxA:
undetectable		 1fkoA-4zoxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.07A 1hsgB-4zoxA:
undetectable		 1hsgB-4zoxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.01A 1sdtB-4zoxA:
undetectable		 1sdtB-4zoxA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.08A 1sduB-4zoxA:
undetectable		 1sduB-4zoxA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4zox 60S RIBOSOMAL
PROTEIN L10
RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 113
GLY A 109
GLY A 131
ARG B   3
 None
 0.68A 2wd9A-4zoxA:
undetectable		 2wd9A-4zoxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4zox 60S RIBOSOMAL
PROTEIN L10
RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 113
GLY A 109
GLY A 131
ARG B   3
 None
 0.67A 2wd9B-4zoxA:
undetectable		 2wd9B-4zoxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.10A 2z54A-4zoxA:
undetectable		 2z54A-4zoxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 383
PHE A 349
LEU A 365
PHE A 360
 None
 1.08A 3ablP-4zoxA:
undetectable
3ablW-4zoxA:
undetectable		 3ablP-4zoxA:
22.88
3ablW-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 262
THR A 212
PHE A 242
ASN A 270
GLY A 269
 None
 1.45A 3aodC-4zoxA:
undetectable		 3aodC-4zoxA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 117
GLY A 122
GLY A 142
CYH A 115
 None
 0.91A 3ko0M-4zoxA:
undetectable
3ko0P-4zoxA:
undetectable		 3ko0M-4zoxA:
14.79
3ko0P-4zoxA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.11A 3nu6B-4zoxA:
undetectable		 3nu6B-4zoxA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.04A 3oxxC-4zoxA:
undetectable		 3oxxC-4zoxA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 365
GLN A 376
PHE A 349
LEU A 337
 None
 0.90A 3x2qC-4zoxA:
undetectable
3x2qJ-4zoxA:
undetectable		 3x2qC-4zoxA:
22.88
3x2qJ-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 365
GLN A 376
PHE A 349
LEU A 337
 None
 0.93A 3x2qP-4zoxA:
undetectable
3x2qW-4zoxA:
undetectable		 3x2qP-4zoxA:
22.88
3x2qW-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 390
ASN A  55
SER A 368
ASN A 392
LEU A 425
 None
 1.17A 4pooA-4zoxA:
undetectable		 4pooA-4zoxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
CYH A 115
PHE A 117
LEU A  79
GLY A  72
 None
 1.41A 4zbrA-4zoxA:
undetectable		 4zbrA-4zoxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 383
PHE A 349
LEU A 365
PHE A 360
 None
 1.14A 5b1bC-4zoxA:
undetectable
5b1bJ-4zoxA:
undetectable		 5b1bC-4zoxA:
22.88
5b1bJ-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 239
GLY A 238
GLN A 201
TRP A 233
 None
 1.04A 5vlmD-4zoxA:
undetectable		 5vlmD-4zoxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4zox RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 193
TRP A 180
VAL A 179
 None
 1.09A 6auuA-4zoxA:
undetectable		 6auuA-4zoxA:
20.27