SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		3 / 3 ASP A  68
PHE A  24
ARG A  70
 None
 0.90A 2a3aA-4zpiA:
undetectable		 2a3aA-4zpiA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 HIS A 102
ALA A 203
GLY A 104
GLY A  16
ASP A 119
 FE2  A 301 (-3.5A)
None
None
None
None
 1.06A 2f8lA-4zpiA:
undetectable		 2f8lA-4zpiA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		4 / 8 ASN A 105
LYS A 161
PRO A 134
PHE A 229
 None
 0.96A 3bjwD-4zpiA:
undetectable		 3bjwD-4zpiA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 TYR A 155
GLY A  16
GLY A 158
SER A 159
LEU A 204
 None
 0.92A 3e23A-4zpiA:
undetectable		 3e23A-4zpiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		3 / 3 VAL A 257
VAL A 180
SER A 182
 None
 0.70A 3n8xB-4zpiA:
undetectable		 3n8xB-4zpiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  36
ALA A 221
GLY A  88
GLY A  90
LEU A 219
 None
 1.20A 3ou7A-4zpiA:
undetectable		 3ou7A-4zpiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  36
ALA A 221
GLY A  88
GLY A  90
LEU A 219
 None
 1.18A 3ou7B-4zpiA:
undetectable		 3ou7B-4zpiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A  36
ALA A 221
GLY A  88
GLY A  90
LEU A 219
 None
 1.18A 3ou7D-4zpiA:
undetectable		 3ou7D-4zpiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 199
PHE A  12
GLY A 223
LEU A  86
PHE A 229
 None
 1.35A 3tbgA-4zpiA:
undetectable		 3tbgA-4zpiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 11 LEU A 187
THR A 186
VAL A 156
LEU A 167
PHE A 256
 None
 1.13A 3tbgA-4zpiA:
undetectable		 3tbgA-4zpiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		3 / 3 ARG A 233
LEU A 235
GLU A 234
 None
 0.69A 4l3gF-4zpiA:
undetectable		 4l3gF-4zpiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 200
LEU A 139
ARG A 217
THR A  15
ILE A  11
 None
 1.24A 4oktA-4zpiA:
undetectable		 4oktA-4zpiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 ALA A 138
HIS A 102
HIS A 206
LEU A  85
TYR A  89
 None
FE2  A 301 (-3.5A)
FE2  A 301 (-3.6A)
None
None
 1.39A 4r7lA-4zpiA:
undetectable		 4r7lA-4zpiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 THR A 220
ALA A 138
TYR A 224
LEU A 199
VAL A  75
 None
 1.20A 5hw4A-4zpiA:
undetectable		 5hw4A-4zpiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		5 / 12 THR A 220
ALA A 138
TYR A 224
LEU A 199
VAL A  75
 None
 1.19A 5hw4C-4zpiA:
undetectable		 5hw4C-4zpiA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4zpi PUTATIVE
OXIDASE/HYDROXYLASE
(Streptomyces
hygroscopicus) 		4 / 6 GLY A 246
THR A 230
TYR A 135
TYR A 247
 None
 1.27A 6ag0A-4zpiA:
undetectable		 6ag0A-4zpiA:
16.11