SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zpj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 9 LEU A 194
LEU A 392
GLU A 170
LYS A 388
GLN A 414
 None
 1.21A 1gx8A-4zpjA:
undetectable		 1gx8A-4zpjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 11 GLY A 263
PRO A 264
HIS A 283
HIS A 224
GLN A 295
 ZN  A 505 ( 4.4A)
None
None
None
None
 1.25A 1jzsA-4zpjA:
undetectable		 1jzsA-4zpjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 383
PHE A 115
LEU A 149
ILE A 381
LEU A 395
 None
 1.18A 1lhuA-4zpjA:
undetectable		 1lhuA-4zpjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLU A 234
ASN A 201
ILE A 257
GLY A 284
SER A 310
 None
 1.39A 1q8jA-4zpjA:
2.5		 1q8jA-4zpjA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 8 ALA A 151
VAL A  85
LEU A 108
THR A 105
 None
 0.77A 2it4A-4zpjA:
undetectable		 2it4A-4zpjA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 104
ILE A 174
LEU A 395
VAL A 120
PHE A 115
 None
 1.09A 2ygpA-4zpjA:
undetectable		 2ygpA-4zpjA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 10 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.13A 3a3yA-4zpjA:
2.5		 3a3yA-4zpjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 7 VAL A 167
ILE A 150
GLY A  84
ARG A  82
 None
 0.90A 3bjwF-4zpjA:
undetectable		 3bjwF-4zpjA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 415
VAL A 175
LEU A 447
ASP A 446
ALA A 200
 None
None
CL  A 517 ( 4.7A)
None
None
 1.24A 3d91B-4zpjA:
undetectable		 3d91B-4zpjA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 111
LEU A 108
LEU A 378
ILE A 174
LEU A 395
 None
 1.09A 3hj3D-4zpjA:
undetectable		 3hj3D-4zpjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 129
ALA A 134
THR A 138
ILE A 150
ILE A  83
 None
 1.21A 3ld6A-4zpjA:
undetectable		 3ld6A-4zpjA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		3 / 3 GLN A 133
GLU A 125
LYS A 137
 None
ZN  A 507 (-2.1A)
ZN  A 507 ( 4.1A)
 1.17A 3su9A-4zpjA:
undetectable		 3su9A-4zpjA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 9 PHE A 292
LEU A 307
VAL A 279
LEU A 266
ILE A 269
 None
 1.07A 3tbgD-4zpjA:
undetectable		 3tbgD-4zpjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 151
GLY A 152
GLY A 370
ILE A 374
 None
 0.67A 4eatA-4zpjA:
5.4		 4eatA-4zpjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.19A 4hytA-4zpjA:
undetectable		 4hytA-4zpjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.18A 4hytC-4zpjA:
undetectable		 4hytC-4zpjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 8 ALA A 230
GLN A 181
ASP A 446
ASP A 205
 None
 0.87A 4ndnB-4zpjA:
undetectable		 4ndnB-4zpjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.18A 4retA-4zpjA:
undetectable		 4retA-4zpjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.18A 4retC-4zpjA:
undetectable		 4retC-4zpjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 VAL A 373
LEU A 391
LEU A 194
LEU A 183
ALA A 178
 None
 1.43A 4rtbA-4zpjA:
undetectable		 4rtbA-4zpjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 PHE A 409
GLY A 415
TYR A 365
LEU A 334
PHE A 407
 None
 1.46A 4xldA-4zpjA:
undetectable		 4xldA-4zpjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 10 GLY A 370
ALA A 377
VAL A 373
GLU A 376
ILE A 174
 None
 1.00A 5i3cB-4zpjA:
3.3		 5i3cB-4zpjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 11 GLY A 370
ALA A 377
VAL A 373
GLU A 376
ILE A 174
 None
 1.14A 5i3cC-4zpjA:
undetectable		 5i3cC-4zpjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 8 THR A 173
SER A 198
ALA A 159
SER A 156
 None
 1.06A 5l5fY-4zpjA:
undetectable
5l5fZ-4zpjA:
undetectable		 5l5fY-4zpjA:
18.42
5l5fZ-4zpjA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 8 GLY A 129
ASN A 157
SER A 156
ALA A 178
 None
 0.99A 5xu8A-4zpjA:
undetectable		 5xu8A-4zpjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		5 / 12 ILE A  81
GLY A 112
ALA A 111
ASP A 109
ILE A 374
 None
 1.10A 6dwnD-4zpjA:
undetectable		 6dwnD-4zpjA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Sphaerobacter
thermophilus) 		4 / 6 ALA A 289
LEU A 362
THR A 333
ASN A 435
 None
 0.81A 6f88B-4zpjA:
undetectable		 6f88B-4zpjA:
15.24