SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 12 VAL A 275
LEU A 222
TYR A 287
GLY A 277
PRO A 278
 None
 1.40A 1fdsA-4zpqA:
undetectable		 1fdsA-4zpqA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 7 GLU A  91
LEU A   2
VAL A  19
LEU A  37
 None
 0.92A 1hk3A-4zpqA:
undetectable		 1hk3A-4zpqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 9 ALA A 237
GLY A 303
ALA A 293
LEU A 266
LEU A 235
 None
 1.14A 1nr6A-4zpqA:
undetectable		 1nr6A-4zpqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 7 ARG A 294
ASN A 207
PRO A 211
ALA A 210
 None
CA  A 401 (-3.3A)
None
None
 1.35A 2ejgB-4zpqA:
undetectable		 2ejgB-4zpqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 12 VAL A   6
VAL A  92
LEU A  75
GLY A  43
LEU A  55
 None
 1.01A 3n8yB-4zpqA:
undetectable		 3n8yB-4zpqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 4 ASP A 130
ASP A 187
GLY A 195
THR A 142
 CA  A 404 (-2.4A)
CA  A 404 (-3.8A)
None
None
 1.39A 3tl9B-4zpqA:
undetectable		 3tl9B-4zpqA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 4 PRO A  76
LEU A  75
ILE A  94
ARG A  63
 None
 1.45A 3w1wA-4zpqA:
undetectable		 3w1wA-4zpqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 4 HIS A 179
ALA A 177
VAL A 203
GLU A 174
 None
None
None
CA  A 403 ( 2.5A)
 1.10A 4n6pA-4zpqA:
undetectable		 4n6pA-4zpqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		3 / 3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 407 (-1.9A)
None
None
 0.93A 5lsuB-4zpqA:
undetectable		 5lsuB-4zpqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 10 ILE A  61
LEU A  66
ARG A  44
GLY A  43
PHE A  46
 None
 1.04A 5mxbA-4zpqA:
undetectable		 5mxbA-4zpqA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 9 ALA A 237
ILE A 307
LEU A 218
ILE A 273
ALA A 293
 None
 1.00A 5nunA-4zpqA:
undetectable		 5nunA-4zpqA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		5 / 12 LEU A 222
THR A 226
PHE A 252
VAL A 260
ILE A 289
 None
 1.30A 5tuiB-4zpqA:
undetectable		 5tuiB-4zpqA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 6 ILE A 202
LEU A 167
PHE A 149
HIS A 148
 None
 0.91A 5vkqA-4zpqA:
undetectable
5vkqB-4zpqA:
undetectable		 5vkqA-4zpqA:
11.27
5vkqB-4zpqA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zpq MCG133388, ISOFORM
CRA_F
(Mus
musculus) 		4 / 6 ILE A 202
LEU A 167
PHE A 149
HIS A 148
 None
 0.90A 5vkqA-4zpqA:
undetectable
5vkqD-4zpqA:
undetectable		 5vkqA-4zpqA:
11.27
5vkqD-4zpqA:
11.27