SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		5 / 11 TYR B 340
HIS B 291
THR B 301
THR B 302
GLU B 318
 None
 1.50A 2dttD-4zprB:
undetectable
2dttE-4zprB:
undetectable		 2dttD-4zprB:
16.76
2dttE-4zprB:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7J_A_TESA203_1
(ANDROGEN RECEPTOR)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		5 / 12 LEU B 192
MET B 109
MET B 120
THR B 136
MET B 144
 None
 1.30A 2q7jA-4zprB:
undetectable		 2q7jA-4zprB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		4 / 7 HIS B 246
HIS B 291
TYR B 279
TYR B 305
 None
 1.33A 2vmyA-4zprB:
undetectable
2vmyB-4zprB:
undetectable		 2vmyA-4zprB:
20.69
2vmyB-4zprB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		4 / 8 TYR B 279
TYR B 305
HIS B 246
HIS B 291
 None
 1.33A 2vmyA-4zprB:
undetectable
2vmyB-4zprB:
undetectable		 2vmyA-4zprB:
20.69
2vmyB-4zprB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		5 / 12 LEU B 192
MET B 109
MET B 120
THR B 136
MET B 144
 None
 1.30A 2yhdA-4zprB:
undetectable		 2yhdA-4zprB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		5 / 12 ASN B 339
VAL B 336
PHE B 252
LEU B 262
ILE B 259
 None
 1.43A 3elzC-4zprB:
undetectable		 3elzC-4zprB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		4 / 5 LEU B 122
THR B 174
GLU B 126
HIS B 130
 None
 1.38A 3n58C-4zprB:
undetectable		 3n58C-4zprB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		4 / 5 ASP B 106
SER B  65
VAL B 110
GLY B 107
 None
 1.11A 3rxhA-4zprB:
undetectable		 3rxhA-4zprB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		3 / 3 PRO B 228
VAL B 336
HIS B 246
 None
 0.84A 4pevC-4zprB:
undetectable		 4pevC-4zprB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
(Mus
musculus) 		4 / 8 THR B 301
THR B 302
TYR B 305
PRO B 230
 None
 1.36A 5x2sI-4zprB:
undetectable
5x2sJ-4zprB:
undetectable
5x2sK-4zprB:
undetectable		 5x2sI-4zprB:
18.03
5x2sJ-4zprB:
17.49
5x2sK-4zprB:
18.03